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Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity

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Abstract

Efficient and versatile synthetic procedures towards novel derivatives of betulonic acid via Mannich reaction, Sonogashira cross-coupling, and copper(i)-catalyzed 1,3-dipolar cyclo-additions were developed. Introduction of secondary amines (Mannich reaction) into betulonic acid amides led to derivatives possessing marked spasmolytic activity, which is not characteristic of the triterpene fragment.

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Authors and Affiliations

  1. V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, 3 ul. Institutskaya, 630090, Novosibirsk, Russian Federation

    A. I. Govdi & S. F. Vasilevsky

  2. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent´eva, 630090, Novosibirsk, Russian Federation

    I. V. Sorokina, D. S. Baev, A. O. Bryzgalov, T. G. Tolstikova & G. A. Tolstikov

  3. Novosibirsk State Pedagogical University, 28 ul. Vilyuiskaya, 630126, Novosibirsk, Russian Federation

    I. V. Sorokina

  4. Novosibirsk State University, 2 ul. Pirogova, 630090, Novosibirsk, Russian Federation

    T. G. Tolstikova & S. F. Vasilevsky

Authors
  1. A. I. Govdi
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  2. I. V. Sorokina
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  3. D. S. Baev
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  4. A. O. Bryzgalov
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  5. T. G. Tolstikova
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  6. G. A. Tolstikov
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  7. S. F. Vasilevsky
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Corresponding author

Correspondence to S. F. Vasilevsky.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1327–1334, June, 2015.

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Govdi, A.I., Sorokina, I.V., Baev, D.S. et al. Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity. Russ Chem Bull 64, 1327–1334 (2015). https://doi.org/10.1007/s11172-015-1013-4

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  • DOI: https://doi.org/10.1007/s11172-015-1013-4

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