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Palladium-catalyzed selective hydrogenolysis of N-alkyl(aryl)-substituted γ-keto amides as an approach to γ-lactams or linear amides

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Abstract

A palladium-catalyzed hydrogenolysis of N-substituted γ-keto amides can proceed with participation of tautomeric 5-hydroxypyrrolidin-2-ones and give either pyrrolidin-2-ones, or linear amides, or their mixtures, depending on the substrate structure.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    O. V. Turova, V. G. Berezhnaya, E. V. Starodubtseva & M. G. Vinogradov

Authors
  1. O. V. Turova
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  2. V. G. Berezhnaya
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  3. E. V. Starodubtseva
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  4. M. G. Vinogradov
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Corresponding author

Correspondence to M. G. Vinogradov.

Additional information

On the occasion of the 100th anniversary of the birth of Academician N. K. Kochetkov (1915—2005).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1065—1068, May, 2015.

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Turova, O.V., Berezhnaya, V.G., Starodubtseva, E.V. et al. Palladium-catalyzed selective hydrogenolysis of N-alkyl(aryl)-substituted γ-keto amides as an approach to γ-lactams or linear amides. Russ Chem Bull 64, 1065–1068 (2015). https://doi.org/10.1007/s11172-015-0978-3

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  • DOI: https://doi.org/10.1007/s11172-015-0978-3

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