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5′-Norcarbocyclic nucleoside analogs

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Abstract

The present review briefly outlines main methods for the synthesis of 5′-norcarbocyclic nucleoside analogs and the biological activity spectrum of these compounds. Antiviral, antitumor, antibacterial, and anti-inflammatory properties of 5′-norcarbocyclic nucleoside analogs are described. Cellular enzymes, such as S-adenosylhomocysteine hydrolase, telomerase, adenosine kinase, and inosine monophosphate dehydrogenase, as well as HIV reverse transcriptase, are considered as target enzymes.

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  1. V. A. Engelhardt Institute of Molecular Biology, of Russian Academy of Sciences, 32 ul. Vavilova, 119991, Moscow, Russian Federation

    E. S. Matyugina & A. L. Khandazhinskaya

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  1. E. S. Matyugina
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Based on the materials of the First Russian Conference on Medicinal Chemistry (“MedChem Russia-2013”) with International Participation (September 8–12, 2013, Moscow).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1069–1080, May, 2014.

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Matyugina, E.S., Khandazhinskaya, A.L. 5′-Norcarbocyclic nucleoside analogs. Russ Chem Bull 63, 1069–1080 (2014). https://doi.org/10.1007/s11172-014-0551-5

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