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Introduction of two novel biocompatible deep eutectic mixtures for the promotion of the green synthesis of triazoloquinazolines: a comparative study

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Abstract

In this study, two new deep eutectic mixtures were prepared via combination of D-fructose with urea and L-aspartic acid or L-arginine. After identification, the catalytic activity of these mixtures, was evaluated in the one-pot multi-component synthesis of tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one derivatives. In the presence of both prepared mixtures the desired products were obtained with high diversity from the reaction of 3-amino-1,2,4-triazole, aromatic aldehydes and dimedone or cyclohexanedione in short reaction times with good yields. The reported methods have notable features such as easy preparation of the catalysts, green processes, cost-effectiveness and simple work-up procedures. Addintionally, the catalysts are easily recoverable and can be recycled up to five times without substantial loss of their activity.

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All data generated or analyzed during this study are included in this published article [and its supplementary information files].

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Acknowledgements

The help of the Research Council of Guilan University in doing this work is acknowledged.

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  1. Department of Chemistry, College of Science, University of Guilan, Rasht, 41335, Islamic Republic of Iran

    Sarvin Yazdanfar & Farhad Shirini

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  1. Sarvin Yazdanfar
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  2. Farhad Shirini
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by SY and FS. The first draft of the manuscript was written by SY and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Farhad Shirini.

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Yazdanfar, S., Shirini, F. Introduction of two novel biocompatible deep eutectic mixtures for the promotion of the green synthesis of triazoloquinazolines: a comparative study. Res Chem Intermed 49, 5205–5220 (2023). https://doi.org/10.1007/s11164-023-05132-1

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