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Synthesis and antimicrobial activity of p-menth-3-en-1-amine amide derivatives

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Abstract

A series of p-menth-3-en-1-amine amide derivatives were designed and synthesized. These compounds were identified by FT-IR, ESI+-MS, HRMS, 1H NMR and 13C NMR. Their antimicrobial activity against gram-positive Staphylococcus aureus, gram-negative Klebsiella pneumoniae and Candida albicans was investigated using the microbroth dilution method. The result indicated that some of these newly synthesized compounds had remarkable antimicrobial activity, and the suitable substituent groups were essential for high antimicrobial activity. Compound 5 g displayed the same antimicrobial activity against K. pneumoniae as commercially available antibacterial agents (kanamycin sulfate and rifampicin). The MIC of compound 5 g against K. pneumoniae only was 0.44 µg/mL.

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Authors and Affiliations

  1. Institute of Chemical Industry of Forest Products, CAF, Nanjing, 210042, China

    Shouji Zhu, Shichao Xu & Zhendong Zhao

  2. Key and Open Lab. On Forest Chemical Engineering, SFA, Nanjing, 210042, China

    Shouji Zhu, Shichao Xu & Zhendong Zhao

  3. Research Institute of Forestry New Technology, CAF, Beijing, 100091, China

    Shouji Zhu, Shichao Xu & Zhendong Zhao

  4. College of Material Science and Technology, Bejing Forestry University, Beijing, 100083, China

    Shouji Zhu & Jianxin Jiang

Authors
  1. Shouji Zhu
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  2. Shichao Xu
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  3. Zhendong Zhao
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  4. Jianxin Jiang
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Corresponding author

Correspondence to Zhendong Zhao.

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Zhu, S., Xu, S., Zhao, Z. et al. Synthesis and antimicrobial activity of p-menth-3-en-1-amine amide derivatives. Res Chem Intermed 43, 3415–3430 (2017). https://doi.org/10.1007/s11164-016-2833-z

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  • DOI: https://doi.org/10.1007/s11164-016-2833-z

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