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Synthesis of acylhydrazines and, symmetrical and asymmetrical diacylhydrazines from carboxylic acid via the Vilsmeier reagent mediated process

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Abstract

(Chloromethylene)dimethylammonium chloride (Vilsmeier reagent) has been used as an efficient and convenient reagent for the one-pot synthesis of acylhydrazines and symmetrical and asymmetrical diacylhydrazines from carboxylic acids. This reaction proceeded smoothly under mild conditions and it is quite practical, since the starting carboxylic acids can be easily handled and stored. Cleanliness, simplicity of the method and good to excellent yield of products are other advantages of this method.

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Acknowledgments

The authors thank the University of Hormozgan Research Council for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Hormozgan, Bandar Abbas, 71961, Iran

    Maaroof Zarei & Maliheh Eslami Nakhli

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  1. Maaroof Zarei
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  2. Maliheh Eslami Nakhli
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Correspondence to Maaroof Zarei.

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Zarei, M., Nakhli, M.E. Synthesis of acylhydrazines and, symmetrical and asymmetrical diacylhydrazines from carboxylic acid via the Vilsmeier reagent mediated process. Res Chem Intermed 43, 1909–1918 (2017). https://doi.org/10.1007/s11164-016-2738-x

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  • DOI: https://doi.org/10.1007/s11164-016-2738-x

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