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Microwave-assisted clean synthesis of xanthenes and chromenes in [bmim][PF6] and their antioxidant studies

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Abstract

An efficient one-pot synthesis of xanthene and chromene derivatives by three-component reactions of aryl aldehydes, cyclic 1,3-diketones, and 2-naphthol/4-hydroxy coumarin catalyzed by ionic liquid (IL) [bmim][PF6] under microwave irradiation is described. The present scheme provides several advantages such as short reaction time, mild reaction conditions, good yields, convenient operation, and reuse of IL. In vitro antioxidant activity was evaluated for the synthesized compounds by DPPH method. Compounds 6a, 6h, 6c, 6b, 4k, and 4a showed the highest antioxidant potency.

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Acknowledgments

The authors are thankful to the administration of VIT University, Vellore, India, for providing facilities to conduct research work and are also thankful to SIF-Chemistry, VIT University, for providing NMR and IR spectral facilities. Author P. Iniyavan is thankful to the VIT University for providing an Research Associateship.

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Authors and Affiliations

  1. Centre for Organic and Medicinal Chemistry, VIT University, Vellore, 632014, Tamil Nadu, India

    P. Iniyavan, S. Sarveswari & V. Vijayakumar

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  1. P. Iniyavan
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  2. S. Sarveswari
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  3. V. Vijayakumar
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Correspondence to V. Vijayakumar.

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Iniyavan, P., Sarveswari, S. & Vijayakumar, V. Microwave-assisted clean synthesis of xanthenes and chromenes in [bmim][PF6] and their antioxidant studies. Res Chem Intermed 41, 7413–7426 (2015). https://doi.org/10.1007/s11164-014-1821-4

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