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Convenient one-pot synthesis of N-acyl-1,3-diaryl-2-azaphenalene derivatives via solvent-free five-component condensation reactions

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Abstract

N-Acyl-1,3-diaryl-2-azaphenalene derivatives have been synthesized by one-pot condensation reaction of aromatic aldehydes, 2,7-naphthalenediol, carboxylic acids, and aqueous ammonia (25 %). Different aromatic aldehydes and carboxylic acids have been used in the reaction and the products were always obtained in good to high yields. The method is simple, solvent free, and involves a short reaction time. These relatively rapid reactions possibly proceed via a Betti reaction mechanism.

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Acknowledgments

We gratefully acknowledge financial support from the Research Council of Arak University.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Arak University, Arak, 38156-879, Iran

    Akbar Mobinikhaledi, Hassan Moghanian & Reza Mozaffari

  2. Faculty of Chemistry, Islamic Azad University, North Branch, Tehran, Iran

    Naser Foroughifar

Authors
  1. Akbar Mobinikhaledi
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  2. Naser Foroughifar
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  3. Hassan Moghanian
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  4. Reza Mozaffari
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Correspondence to Hassan Moghanian.

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Mobinikhaledi, A., Foroughifar, N., Moghanian, H. et al. Convenient one-pot synthesis of N-acyl-1,3-diaryl-2-azaphenalene derivatives via solvent-free five-component condensation reactions. Res Chem Intermed 41, 6523–6532 (2015). https://doi.org/10.1007/s11164-014-1758-7

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  • DOI: https://doi.org/10.1007/s11164-014-1758-7

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