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Copper incorporated hydroxyapatite encapsulated Kit-6 mesoporous silica as a novel and recoverable nanocatalyst for the synthesis of quinazolines

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Abstract

This research work describes the synthesis of copper incorporated hydroxyapatite encapsulated Kit-6 (Cu@HAp@KIT-6) as a novel and impactful nanocatalyst and evaluation of its activity in the synthesis of quinazoline derivatives by a three-component reaction of 2-amino-5-chlorobenzophenone, ammonium acetate, and aromatic aldehydes in ethanol. This practical method produced the products with high to excellent yields (85–96%) and reasonable reaction time (1 h). The nanocatalyst was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscope, energy dispersive analysis of X-rays, thermogravimetric analysis, differential thermogravimetric, and Transmission electron microscopy. The recyclability of the catalyst was also examined which preserved its main catalytic activity after six consecutive runs.

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Acknowledgements

The authors would like to thank the Research Council of University of Guilan for partial financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, University Campus 2, University of Guilan, Rasht, Iran

    Dornaz Pirdelzendeh

  2. Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box, 41335-1914, Rasht, Iran

    Manouchehr Mamaghani, Farhad Shirini & Mehdi Sheykhan

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  1. Dornaz Pirdelzendeh
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  2. Manouchehr Mamaghani
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  3. Farhad Shirini
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  4. Mehdi Sheykhan
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Correspondence to Manouchehr Mamaghani.

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Pirdelzendeh, D., Mamaghani, M., Shirini, F. et al. Copper incorporated hydroxyapatite encapsulated Kit-6 mesoporous silica as a novel and recoverable nanocatalyst for the synthesis of quinazolines. Reac Kinet Mech Cat 133, 441–454 (2021). https://doi.org/10.1007/s11144-021-02002-y

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