Skip to main content
SpringerLink
Log in

Novel prognostic factors for successful treatment of pediatric chronic rhinosinusitis using the sinus and nasal quality of life survey (SN-5H)

  • Published:
Quality of Life Research Aims and scope Submit manuscript

Abstract

Introduction

Chronic rhinosinusitis (CRS) is strongly associated with significant impairment of quality of life (QoL) in children. The SN-5 questionnaire is an important assessment tool for pediatric CRS. This study aimed to evaluate potential prognostic factors for treatment of pediatric CRS within the Hebrew version of the SN-5 questionnaire.

Methods

A prospective study in pediatric otolaryngology unit. Patients were treated either surgically or pharmacologically. Following informed consent, parents of pediatric CRS patients completed the translated and validated Hebrew version (SN-5H) prior to treatment and after three months. We analyzed the results of both treatment arms according to success (achieving minimal clinically important difference; MCID).

Results

102 children aged 5–12 years and their caregivers participated (74 CRS patients and 28 controls without CRS). SN-5H items scores were significantly higher in CRS patients compared to controls (p < 0.001). Baseline activity scores were higher, while baseline emotional scores were lower in MCID( +) CRS patients, compared to MCID(-) CRS patients (p < 0.05). High emotional stress and low activity scores at baseline were associated with poorer odds to achieve MCID.

Conclusions

The SN-5H questionnaire is invaluable tool for assessing pediatric CRS patients. Psychosocial aspects of CRS significantly affect QoL and should be addressed in the office pre-treatment. The SN-5H can aid in highlighting patients in need for further reassurance and psychosocial support to manage expectations, and to improve QoL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Data Availability

The data that support the findings of this study are available on request from the corresponding author [O.Z].

References

  1. Cunningham, M. J., Chiu, E. J., Landgraf, J. M., & Gliklich, R. E. (2000). The health impact of chronic recurrent rhinosinusitis in children. Archives of otolaryngology--head & neck surgery, 126(11), 1363–1368.

  2. Rudnick, E. F., & Mitchell, R. B. (2006). Improvements in quality of life in children after surgical therapy for Sinonasal disease. Otolaryngology-Head and Neck Surgery, 134(5), 737–740. https://doi.org/10.1016/j.otohns.2005.12.033

    Article  PubMed  Google Scholar 

  3. Fokkens, W. J., Lund, V. J., Hopkins, C., Hellings, P. W., Kern, R., Reitsma, S., Toppila-Salmi, S., Bernal-Sprekelsen, M., Mullol, J., Alobid, I., Terezinha Anselmo-Lima, W., Bachert, C., Baroody, F., von Buchwald, C., Cervin, A., Cohen, N., Constantinidis, J., De Gabory, L., Desrosiers, M., Diamant, Z., … Zwetsloot, C. P. (2020). European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology, 58(Suppl S29), 1–464. https://doi.org/10.4193/Rhin20.600

  4. Gilani, S., & Shin, J. J. (2017). The burden and visit prevalence of pediatric chronic rhinosinusitis. Otolaryngology-Head and Neck Surgery, 157(6), 1048–1052. https://doi.org/10.1177/0194599817721177

    Article  PubMed  Google Scholar 

  5. Garratt, A., Schmidt, L., Mackintosh, A., & Fitzpatrick, R. (2002). Quality of life measurement: Bibliographic study of patient assessed health outcome measures. BMJ (Clinical research ed.), 324(7351), 1417. https://doi.org/10.1136/bmj.324.7351.1417

    Article  PubMed  Google Scholar 

  6. Hopkins, C., Gillett, S., Slack, R., Lund, V. J., & Browne, J. P. (2009). Psychometric validity of the 22-item Sinonasal Outcome Test. Clinical Otolaryngology, 34(5), 447–454.

    Article  CAS  PubMed  Google Scholar 

  7. Stewart, M. G., Witsell, D. L., Smith, T. L., Weaver, E. M., Yueh, B., & Hannley, M. T. (2004). Development and validation of the nasal obstruction symptom evaluation (nose) scale. Otolaryngology-Head and Neck Surgery, 130(2), 157–163. https://doi.org/10.1016/j.otohns.2003.09.016

    Article  PubMed  Google Scholar 

  8. Kay, D. J., & Rosenfeld, R. M. (2003). Quality of life for children with persistent sinonasal symptoms. Otolaryngology-Head and Neck Surgery, 128(1), 17–26. https://doi.org/10.1067/mhn.2003.41

    Article  PubMed  Google Scholar 

  9. Gargula, S., Luscan, R., Drummond, D., Denoyelle, F., Couloigner, V., Leboulanger, N., & Simon, F. (2021). French translation and validation of the Sinus and Nasal Quality of Life Survey (SN-5) in children. International Journal of Pediatric Otorhinolaryngology, 145, 110706.

    Article  PubMed  Google Scholar 

  10. Calvo-Henríquez, C., Valencia-Blanco, B., Boronat-Catalá, B., Maza-Solano, J., Díaz-Anadón, Á., Kahn, S., Moure-Gonzalez, J. D., Faraldo-García, A., & Martinez-Capoccioni, G. (2020). Cross-cultural adaptation of the sinus and nasal quality of life survey (SN-5) to Spanish. International Journal of Pediatric Otorhinolaryngology. https://doi.org/10.1016/j.ijporl.2020.110425

    Article  PubMed  Google Scholar 

  11. World Health Organization (2015). Process of Translation and Adaption of Instruments. http://www.who.int/substance_abuse/research_tools/translation/en

  12. Bobak, C. A., Barr, P. J., & O’Malley, A. J. (2018). Estimation of an inter-rater intra-class correlation coefficient that overcomes common assumption violations in the assessment of health measurement scales. BMC Medical Research Methodology, 18(1), 93. https://doi.org/10.1186/s12874-018-0550-6

    Article  PubMed  PubMed Central  Google Scholar 

  13. Alobid, I., Benítez, P., Bernal-Sprekelsen, M., Roca, J., Alonso, J., Picado, C., & Mullol, J. (2005). Nasal polyposis and its impact on quality of life: Comparison between the effects of medical and surgical treatments. Allergy, 60(4), 452–458. https://doi.org/10.1111/j.1398-9995.2005.00725.x

    Article  CAS  PubMed  Google Scholar 

  14. Wabnitz, D. A., Nair, S., & Wormald, P. J. (2005). Correlation between preoperative symptom scores, quality-of-life questionnaires, and staging with computed tomography in patients with chronic rhinosinusitis. American Journal of Rhinology, 19(1), 91–96.

    Article  PubMed  Google Scholar 

  15. Tahamiler, R., Canakcioglu, S., Ogreden, S., & Acioglu, E. (2007). The accuracy of symptom-based definition of chronic rhinosinusitis. Allergy, 62(9), 1029–1032. https://doi.org/10.1111/j.1398-9995.2007.01397.x

    Article  CAS  PubMed  Google Scholar 

  16. Eiser, C., & Morse, R. (2001). A review of measures of quality of life for children with chronic illness. Archives of disease in childhood, 84(3), 205–211. https://doi.org/10.1136/adc.84.3.205

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Solans, M., Pane, S., Estrada, M. D., Serra-Sutton, V., Berra, S., Herdman, M., Alonso, J., & Rajmil, L. (2008). Health-related quality of life measurement in children and adolescents: A systematic review of generic and disease-specific instruments. Value in health : The journal of the International Society for Pharmacoeconomics and Outcomes Research, 11(4), 742–764. https://doi.org/10.1111/j.1524-4733.2007.00293.x

    Article  PubMed  Google Scholar 

  18. Rudnick, E. F., & Mitchell, R. B. (2006). Improvements in quality of life in children after surgical therapy for sinonasal disease. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 134(5), 737–740. https://doi.org/10.1016/j.otohns.2005.12.033

  19. Jaeshke, R., Singer, J., & Guyatt, G. (1989). Measurement of health status. Ascertaining the minimal clinically important difference. Controlled Clinical Trials, 10, 407–415.

    Google Scholar 

  20. Mouelhi, Y., Jouve, E., Castelli, C., & Gentile, S. (2020). How is the minimal clinically important difference established in health-related quality of life instruments? Review of anchors and methods. Health and Quality of Life Outcomes, 18(1), 136.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Soler, Z. M., Rosenbloom, J. S., Skarada, D., Gutman, M., Hoy, M. J., & Nguyen, S. A. (2017). Prospective, multicenter evaluation of balloon sinus dilation for treatment of pediatric chronic rhinosinusitis. International Forum of Allergy and Rhinology, 7(3), 221–229.

    Article  PubMed  Google Scholar 

  22. Ni, J. S., Kompelli, A. R., Nguyen, S. A., Schlosser, R. J., Clemmens, C., & Soler, Z. M. (2018). The sinus and nasal quality of life survey (SN-5) in the Management of Pediatric Chronic Rhinosinusitis: A systematic review and meta-analysis. International Journal of Pediatric Otorhinolaryngology, 111, 162–169.

    Article  PubMed  Google Scholar 

  23. Norman, G. R., Sloan, J. A., & Wyrwich, K. W. (2003). Interpretation of changes in health-related quality of life: The remarkable universality of half a standard deviation. Medical Care, 41, 582–592.

    Article  PubMed  Google Scholar 

  24. Chmielik, L. P., Mielnik-Niedzielska, G., Kasprzyk, A., Stankiewicz, T., & Niedzielski, A. (2021). Health-related quality of life assessed in children with chronic rhinitis and sinusitis. Children (Basel, Switzerland), 8(12), 1133.

    PubMed  Google Scholar 

  25. Rolfe, A., Cash-Gibson, L., Car, J., Sheikh, A., & McKinstry, B. (2014). Interventions for improving patients' trust in doctors and groups of doctors. The Cochrane Database of Systematic Reviews, 2014(3), CD004134.

Download references

Funding

Nothing to declare.

Author information

Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Rabin Medical Center and Schneider Children’s Medical Center of Israel, 14Th Kaplan Street, 4920235, Petach Tikva, Israel

    Ofir Zavdy, Gilad Golan, Dan Yaniv, Lirit Levi, Moshe Hain, Roy Hod & Dror Gilony

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Ofir Zavdy, Gilad Golan, Dan Yaniv, Lirit Levi, Moshe Hain, Roy Hod & Dror Gilony

Authors
  1. Ofir Zavdy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gilad Golan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dan Yaniv
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lirit Levi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Moshe Hain
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Roy Hod
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dror Gilony
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ofir Zavdy.

Ethics declarations

Conflict of interest

The authors have no conflict of interests to declare.

Ethical approval

This study protocol was reviewed and approved by Rabin Medical Center IRB committee, R20-1922.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zavdy, O., Golan, G., Yaniv, D. et al. Novel prognostic factors for successful treatment of pediatric chronic rhinosinusitis using the sinus and nasal quality of life survey (SN-5H). Qual Life Res 32, 2541–2549 (2023). https://doi.org/10.1007/s11136-023-03421-1

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11136-023-03421-1

Keywords

Search

Navigation