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Association between physical activity and patient-reported outcome measures in patients with lung cancer: a systematic review and meta-analysis

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Abstract

Objective

The aim of this systematic review was to examine the association between physical activity (PA) and Health-Related Quality of Life (HRQoL) as well as other Patient-Reported Outcome Measures (PROMs) in patients with lung cancer.

Material and Methods

A systematic search was conducted using the following databases: PUBMED, MEDLINE(Ovid), Cochrane Library Plus, Web Of Science (WOS), SCOPUS, SPORTDiscus and PEDro. The last search was conducted in October the 5th, 2021. Articles which explored the association between PA levels and Health-Related Quality of Life (HRQoL) and/or other PROMs were included. Risk of bias was assessed using the Johanna Briggs Institute Critical Appraisal Tools. When appropriate, a meta-analysis was performed to summarise the strength of the association between PA and each PROM.

Results

The electronic search yielded 1,000 records of which 23 were finally selected by two independent reviewers. Moderate associations were found between engaging in PA and global HRQoL (r = 0.41; 95% CI: 0.21 – 0.57; p < .0001) as well as depression (r = -0.33; 95% CI: -0.44, -0.19; p < .001). In addition, small assocaitions were also reported for fatigue (r = -0.23; 95% CI: -0.3, -0.17; p < .001) and dyspnoea (r = -0.25; 95% CI: -0.33, -0.16; p < .001). No significant associations were found for anxiety or sleep.

Conclusions

Although the majority of the studies included some risk of bias, engaging in regular PA seems to be associated with better overall HRQoL, mood and less symptom burden in patients with LC.

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References

  1. Howington, J. A., Blum, M. G., Chang, A. C., Balekian, A. A., & Murthy, S. C. (2013). Treatment of stage i and ii non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest, 143(5), e278S-e313S. https://doi.org/10.1378/chest.12-2359

    Article  CAS  PubMed  Google Scholar 

  2. Jones, L. W., Eves, N. D., Haykowsky, M., Freedland, S. J., & Mackey, J. R. (2009). Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction. The Lancet Oncology, 10(6), 598–605. https://doi.org/10.1016/S1470-2045(09)70031-2

    Article  PubMed  Google Scholar 

  3. Sekine, Y., Chiyo, M., Iwata, T., Yasufuku, K., Furukawa, S., Amada, Y., Iyoda, A., Shibuya, K., Iizasa, T., & Fujisawa, T. (2005). Perioperative rehabilitation and physiotherapy for lung cancer patients with chronic obstructive pulmonary disease. The Japanese Journal of Thoracic and Cardiovascular Surgery, 53(5), 237–243. https://doi.org/10.1007/s11748-005-0032-8

    Article  PubMed  Google Scholar 

  4. Simoff, M. J., Lally, B., Slade, M. G., Goldberg, W. G., Lee, P., Michaud, G. C., Wahidi, M. M., & Chawla, M. (2013). Symptom management in patients with lung cancer: diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest, 143(5), e455S-e497S. https://doi.org/10.1378/chest.12-2366

    Article  CAS  PubMed  Google Scholar 

  5. Cheville, A. L., Novotny, P. J., Sloan, J. A., Basford, J. R., Wampfler, J. A., Garces, Y. I., Jatoi, A., & Yang, P. (2011). The value of a symptom cluster of fatigue, dyspnea, and cough in predicting clinical outcomes in lung cancer survivors. Journal of Pain and Symptom Management, 42(2), 213–221. https://doi.org/10.1016/j.jpainsymman.2010.11.005

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ramon, M. A., ter Riet, G., Carsin, A.-E., Gimeno-Santos, E., Agustí, A., Antó, J. M., Donaire-Gonzalez, D., Ferrer, J., Rodríguez, E., Rodriguez-Roisin, R., Puhan, M. A., & Garcia-Aymerich, J. (2018). The dyspnoea–inactivity vicious circle in COPD: development and external validation of a conceptual model. European Respiratory Journal, 52(3), 1800079. https://doi.org/10.1183/13993003.00079-2018

    Article  PubMed  Google Scholar 

  7. Segal, R., Zwaal, C., Green, E., Tomasone, J. R., Loblaw, A., Petrella, T., & Group, E. for P. with C. G. D. (2017) Exercise for people with cancer: a systematic review. Current Oncology (Toronto, Ont.), 24(4), e290–e315 Doi: https://doi.org/10.3747/co.24.3619

  8. Cheville, A. L., Kollasch, J., Vandenberg, J., Shen, T., Grothey, A., Gamble, G., & Basford, J. R. (2013). A home-based exercise program to improve function, fatigue, and sleep quality in patients with stage iv lung and colorectal cancer: a randomized controlled trial. Journal of Pain and Symptom Management, 45(5), 811–821. https://doi.org/10.1016/j.jpainsymman.2012.05.006

    Article  PubMed  Google Scholar 

  9. Chen, H.-M., Tsai, C.-M., Wu, Y.-C., Lin, K.-C., & Lin, C.-C. (2015). Randomised controlled trial on the effectiveness of home-based walking exercise on anxiety, depression and cancer-related symptoms in patients with lung cancer. British Journal of Cancer, 112(3), 438–445. https://doi.org/10.1038/bjc.2014.612

    Article  PubMed  Google Scholar 

  10. Scott, J. M., Zabor, E. C., Schwitzer, E., Koelwyn, G. J., Adams, S. C., Nilsen, T. S., Moskowitz, C. S., Matsoukas, K., Iyengar, N. M., Dang, C. T., & Jones, L. W. (2018). Efficacy of exercise therapy on cardiorespiratory fitness in patients with cancer: a systematic review and meta-analysis. Journal of Clinical Oncology, 36(22), 2297–2304. https://doi.org/10.1200/JCO.2017.77.5809

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Bland, K. A., Zadravec, K., Landry, T., Weller, S., Meyers, L., & Campbell, K. L. (2019). Impact of exercise on chemotherapy completion rate: a systematic review of the evidence and recommendations for future exercise oncology research. Critical Reviews in Oncology/Hematology, 136, 79–85. https://doi.org/10.1016/j.critrevonc.2019.02.005

    Article  PubMed  Google Scholar 

  12. Li, T., Wei, S. S., Shi, Y., Pang, S., Qin, Q., Yin, J., Deng, Y., Chen, Q., Wei, S. S., Nie, S., & Liu, L. (2016). The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. British Journal of Sports Medicine, 50(6), 339–345. https://doi.org/10.1136/bjsports-2015-094927

    Article  PubMed  Google Scholar 

  13. Meyerhardt, J. A., Heseltine, D., Niedzwiecki, D., Hollis, D., Saltz, L. B., Mayer, R. J., Thomas, J., Nelson, H., Whittom, R., Hantel, A., Schilsky, R. L., & Fuchs, C. S. (2006). Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. Journal of Clinical Oncology, 24(22), 3535–3541. https://doi.org/10.1200/JCO.2006.06.0863

    Article  PubMed  Google Scholar 

  14. Douglas, E. (2005). Exercise in cancer patients. Physical Therapy Reviews, 10(2), 71–88. https://doi.org/10.1179/108331905X43490

    Article  Google Scholar 

  15. Vallance, J. K., Lavallee, C. M., Culos-Reed, N. S., & Trudeau, M. G. (2012). Physical activity is associated with clinically important differences in health-related quality of life among rural and small-town breast cancer survivors. Supportive Care in Cancer, 20(5), 1079–1087. https://doi.org/10.1007/s00520-011-1188-7

    Article  PubMed  Google Scholar 

  16. Mishra, S. I., Scherer, R. W., Geigle, P. M., Berlanstein, D. R., Topaloglu, O., Gotay, C. C., & Snyder, C. (2012). Exercise interventions on health-related quality of life for cancer survivors. The Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD007566.pub2

    Article  PubMed  PubMed Central  Google Scholar 

  17. Zabora, J., BrintzenhofeSzoc, K., Curbow, B., Hooker, C., & Piantadosi, S. (2001). The prevalence of psychological distress by cancer site. Psycho-Oncology, 10(1), 19–28.

    Article  CAS  Google Scholar 

  18. Tang, F., Wang, J., Tang, Z., Kang, M., Deng, Q., & Yu, J. (2016). Quality of life and its association with physical activity among different types of cancer survivors. PLoS ONE. https://doi.org/10.1371/journal.pone.0164971

    Article  PubMed  PubMed Central  Google Scholar 

  19. Karvinen, K. H., Vallance, J., & Walker, P. R. (2016). Newly diagnosed lung cancer patients’ preferences for and beliefs about physical activity prior to chemotherapy. Psychology, Health and Medicine, 21(5), 593–600. https://doi.org/10.1080/13548506.2016.1139739

    Article  PubMed  Google Scholar 

  20. Page, M., McKenzie, J., Bossuyt, P., Boutron, I., Hoffman, T., Mulrow, C., Shamseer, L., & JM, T. (2020). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews 2020. MetaArxiv. https://doi.org/10.31222/osf.io/v7gm2

    Article  Google Scholar 

  21. Fleiss, J. L. (1971). Measuring nominal scale agreement among many raters. Psychological Bulletin, 76(5), 378–382. https://doi.org/10.1037/h0031619

    Article  Google Scholar 

  22. Lipsey, M., & Wilson, D. B. (2000) Practical Meta-Analysis

  23. MM, C., PJ, N., CA, P., SM, R., YI, G., A, J., JA, S., P, Y., Clark, M. M. M. M., Novotny, P. J. P. J., Patten, C. A. C. A., Rausch, S. M. S. M., Garces, Y. I. Y. I., Jatoi, A., Sloan, J. A. J. A., & Yang, P. (2008). Motivational readiness for physical activity and quality of life in long-term lung cancer survivors. 61(1), 117–122. https://pubmed.ncbi.nlm.nih.gov/18243406/

  24. Lin, Y. Y., Liu, M. F., Tzeng, J. I., Lin, C. C., & YY, L., MF, L., JI, T., CC, L., Lin, Y. Y., Liu, M. F., Tzeng, J. I., & Lin, C. C. (2015). Effects of walking on quality of life among lung cancer patients: a longitudinal study. Cancer Nursing, 38(4), 253–259. https://doi.org/10.1097/NCC.0000000000000176

    Article  PubMed  Google Scholar 

  25. Cl, G., Sm, P., & L, E., L, D., Granger, C. L., Parry, S. M., Edbrooke, L., & Denehy, L. (2016). Deterioration in physical activity and function differs according to treatment type in non-small cell lung cancer – future directions for physiotherapy management. Physiotherapy (United Kingdom), 102(3), 256–263. https://doi.org/10.1016/J.PHYSIO.2015.10.007

    Article  Google Scholar 

  26. Edbrooke, L., Granger, C. L., Clark, R. A., & Denehy, L. (2019). Physical activity levels are low in inoperable lung cancer: exploratory analyses from a randomised controlled trial. Journal of Clinical Medicine, 8(9), 1288. https://doi.org/10.3390/jcm8091288

    Article  PubMed Central  Google Scholar 

  27. Feinstein, M. B., Krebs, P., Coups, E. J., Park, B. J., Steingart, R. M., Burkhalter, J., Logue, A., & Ostroff, J. S. (2010). Current dyspnea among long-term survivors of early-stage non-small cell lung cancer. Journal of Thoracic Oncology, 5(8), 1221–1226. https://doi.org/10.1097/JTO.0b013e3181df61c8

    Article  PubMed  PubMed Central  Google Scholar 

  28. Ha, D. M., Prochazka, A., & v, Bekelman, D. B., Stevens-Lapsley, J. E., Chan, E. D., & Keith, R. L. (2021). Association of leisure-time physical activity with health-related quality of life among US lung cancer survivors. JNCI Cancer Spectrum, 5(1), 1–7. https://doi.org/10.1093/jncics/pkaa118

    Article  Google Scholar 

  29. Hechtner, M., Eichler, M., Wehler, B., Buhl, R., Sebastian, M., Stratmann, J., Schmidberger, H., Gohrbandt, B., Peuser, J., Kortsik, C., Nestle, U., Wiesemann, S., Wirtz, H., Wehler, T., Bals, R., Blettner, M., Singer, S., & M, H., M, E., … Singer, S. (2019). Quality of life in NSCLC survivors — a multicenter cross-sectional study. Journal of Thoracic Oncology, 14(3), 420–435. https://doi.org/10.1016/J.JTHO.2018.11.019

    Article  PubMed  Google Scholar 

  30. Huang, X., Zhou, W., & Zhang, Y. (2015). Features of fatigue in patients with early-stage non-small cell lung cancer. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences, 20(3), 268–272.

    Google Scholar 

  31. Nes, L. S., Liu, H., Patten, C. A., Rausch, S. M., Sloan, J. A., Garces, Y. I., Cheville, A. L., Yang, P., Clark, M. M., & L, S. N., H, L., CA, P., SM, R., JA, S., YI, G., AL, C., P, Y., MM, C., Solberg Nes, L., … Clark, M. M. (2012). Physical activity level and quality of life in long term lung cancer survivors. Lung Cancer, 77(3), 611–616. https://doi.org/10.1016/j.lungcan.2012.05.096

    Article  Google Scholar 

  32. Chen, H. M., Wu, Y. C., Tsai, C. M., Tzeng, J. I., & Lin, C. C. (2015). Relationships of circadian rhythms and physical activity with objective sleep parameters in Lung cancer patients. Cancer Nursing, 38(3), 215–223. https://doi.org/10.1097/NCC.0000000000000163

    Article  PubMed  Google Scholar 

  33. Long, N. H., Thanasilp, S., & Thato, R. (2016). A causal model for fatigue in lung cancer patients receiving chemotherapy. European Journal of Oncology Nursing, 21, 242–247. https://doi.org/10.1016/j.ejon.2015.10.010

    Article  PubMed  Google Scholar 

  34. Ran, J., Wang, J., Bi, N., Jiang, W., Zhou, Z., Hui, Z., Liang, J., Feng, Q., & Wang, L. (2017). Health-related quality of life in long-term survivors of unresectable locally advanced non-small cell lung cancer. Radiation Oncology, 12(195), 1–8. https://doi.org/10.1186/s13014-017-0909-6

    Article  Google Scholar 

  35. Piderman, K. M. K. M., Sytsma, T. T. T., Frost, M. H. M. H., Novotny, P. J. P. J., Rausch Osian, S. M. S. M., Solberg Nes, L., Patten, C. A. C. A., Sloan, J. A. J. A., Rummans, T. A. T. A., Bronars, C. A. C. A., Yang, P., Clark, M. M. M. M., & KM, P., TT, S., MH, F., PJ, N., SM, R. O., L, S. N., CA, P., … MM, C. (2015). Improving spiritual well-being in patients with lung cancers. The Journal of Pastoral Care & Counseling : JPCC, 69(3), 156–162. https://doi.org/10.1177/1542305015602711

    Article  Google Scholar 

  36. Sloan, J. A., Cheville, A. L., Liu, H., Novotny, P. J., Wampfler, J. A., Garces, Y. I., Clark, M. M., & Yang, P. (2016). Impact of self-reported physical activity and health promotion behaviors on lung cancer survivorship. Health and Quality of Life Outcomes. https://doi.org/10.1186/s12955-016-0461-3

    Article  PubMed  PubMed Central  Google Scholar 

  37. Jw, W., Xh, G., & N, D., XF, C., L, S., Z, T., DH, Y., ZP, Y., XD, W., JM, Y., Wang, J.-W. W., Gong, X.-H. H., Ding, N., Chen, X.-F. F., Sun, L., Tang, Z., Yu, D.-H. H., Yuan, Z.-P. P., Wang, X.-D. D., & Yu, J.-M. M. (2015). The influence of comorbid chronic diseases and physical activity on quality of life in lung cancer survivors. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 23(5), 1383–1389. https://doi.org/10.1007/s00520-014-2494-7

    Article  Google Scholar 

  38. Lin, Y. Y., Wu, Y. C., Rau, K. M., Lin, C. C., & YY, L., YC, W., KM, R., & CC, L. (2013). Effects of physical activity on the quality of life in Taiwanese lung cancer patients receiving active treatment or off treatment. Cancer Nursing. https://doi.org/10.1097/NCC.0b013e31826fb8bf

    Article  PubMed  Google Scholar 

  39. Js, Y., Hc, Y., Jm, L., Ms, K., Ec, P., Sh, C., Yoo, J. S. J. S., Yang, H. C. H. C., Lee, J. M. J. M., Kim, M. S. M. S., Park, E.-C.E.C., & Chung, S. H. S. H. (2020). The association of physical function and quality of life on physical activity for non-small cell lung cancer survivors. Supportive Care in Cancer, 28(10), 4847–4856. https://doi.org/10.1007/S00520-020-05302-6

    Article  Google Scholar 

  40. Vallance, J. K., Bebb, G. D., Boyle, T., Johnson, S. T., Gardiner, P. A., & D’Silva, A. (2018). Psychosocial health is associated with objectively assessed sedentary time and light intensity physical activity among lung cancer survivors. Mental Health And Physical Activity, 14, 61–65. https://doi.org/10.1016/j.mhpa.2018.02.002

    Article  Google Scholar 

  41. A, D., PA, G., T, B., DG, B., ST, J., JK, V., D’Silva, A., Gardiner, P. A. P. A., Boyle, T., Bebb, D. G. G., Johnson, S. T. S. T., & Vallance, J. K. J. K. (2018). Associations of objectively assessed physical activity and sedentary time with health-related quality of life among lung cancer survivors: A quantile regression approach. 119, 78–84. https://pubmed.ncbi.nlm.nih.gov/29656757/

  42. Lin, Y. Y., Rau, K. M., & Lin, C. C. (2015). Longitudinal study on the impact of physical activity on the symptoms of lung cancer survivors. Supportive Care in Cancer, 23(12), 3545–3553. https://doi.org/10.1007/s00520-015-2724-7

    Article  PubMed  Google Scholar 

  43. Mouri, T., Naito, T., Morikawa, A., Tatematsu, N., Miura, S., Okayama, T., Omae, K., & Takayama, K. (2018). Promotion of behavioral change and the impact on quality of life in elderly patients with advanced cancer: a physical activity intervention of the multimodal nutrition and exercise treatment for advanced cancer program. Asia-Pacific Journal of Oncology Nursing, 5(4), 383–390.

    Article  Google Scholar 

  44. Bade, B. C., Brooks, M. C., Nietert, S. B., Ulmer, A., Thomas, D. D., Nietert, P. J., Scott, J. A. B., Silvestri, G. A., & BC, B., MC, B., SB, N., A, U., DD, T., PJ, N., JB, S., GA, S., Bade, B. C., Brooks, M. C., Nietert, S. B., … Silvestri, G. A. (2018). Assessing the correlation between physical activity and quality of life in advanced lung cancer. Integrative Cancer Therapies, 17(1), 73–79. https://doi.org/10.1177/1534735416684016

    Article  PubMed  Google Scholar 

  45. Coups, E. J. E. J., Park, B. J. B. J., Feinstein, M. B. M. B., Steingart, R. M. R. M., Egleston, B. L. B. L., Wilson, D. J. D. J., Ostroff, J. S. J. S., EJ, C., BJ, P., MB, F., RM, S., BL, E., DJ, W., & JS, O. (2009) Physical Activity among Lung Cancer Survivors: Changes across the Cancer Trajectory and Associations with Quality of Life 18(2), 664–672 Doi: https://doi.org/10.1158/1055-9965.EPI-08-0589

  46. Fujisawa, D., Temel, J. S., Greer, J. A., El-Jawahri, A., Traeger, L., Jacobs, J. M., Cutrono, S., Pirl, W. F., D, F., JS, T., JA, G., A, E.-J., L, T., JM, J., S, C., WF, P., Fujisawa, D., Temel, J. S., Greer, J. A., … Pirl, W. F. (2019) Actigraphy as an assessment of performance status in patients with advanced lung cancer. 17(5), 574–578 Doi: https://doi.org/10.1017/S1478951518001074

  47. Timmerman, J. G., & (Josien), Dekker-van Weering, M. G. H. (Marit), Wouters, M. W. J. M. (Michel), Stuiver, M. M. (Martijn), de Kanter, W. (Wanda), Vollenbroek-Hutten, M. M. R. (Miriam), JGJ, T., MGHM, D. W., MWJMM, W., MMM, S., WW, de K., & MMRM, V.-H. (2018). Physical behavior and associations with health outcomes in operable NSCLC patients: a prospective study. Lung Cancer, 119, 91–98. https://doi.org/10.1016/J.LUNGCAN.2018.03.006

    Article  PubMed  Google Scholar 

  48. Pompili, C., Salati, M., Refai, M., Berardi, R., Onofri, A., Mazzanti, P., & Brunelli, A. (2013). Preoperative quality of life predicts survival following pulmonary resection in stage I non-small-cell lung cancer. European Journal of Cardio-Thoracic Surgery, 43(5), 905–910. https://doi.org/10.1093/ejcts/ezs532

    Article  PubMed  Google Scholar 

  49. Pinheiro, L. C., Zagar, T. M., & Reeve, B. B. (2017). The prognostic value of pre-diagnosis health-related quality of life on survival: a prospective cohort study of older Americans with lung cancer HHS public access. Quality of Life Research, 26(7), 1703–1712. https://doi.org/10.1007/s11136-017-1515-7

    Article  PubMed  PubMed Central  Google Scholar 

  50. Schag, C. A. C., Ganz, P. A., Wing, D. S., Sim, M. S., & Lee, J. J. (1994). Quality of life in adult survivors of lung, colon and prostate cancer. Quality of Life Research, 3(2), 127–141. https://doi.org/10.1007/BF00435256

    Article  CAS  PubMed  Google Scholar 

  51. Lemonnier, I., Baumann, C., Jolly, D., Arveux, P., Woronoff-Lemsi, M. C., Velten, M., & Guillemin, F. (2011). Solitary pulmonary nodules: consequences for patient quality of life. Quality of Life Research, 20(1), 101–109. https://doi.org/10.1007/s11136-010-9719-0

    Article  PubMed  Google Scholar 

  52. Sebio Garcia, R., Yáñez Brage, M. I., Giménez Moolhuyzen, E., Granger, C. L., & Denehy, L. (2016). Functional and postoperative outcomes after preoperative exercise training in patients with lung cancer: a systematic review and meta-analysis. Interactive Cardiovascular and Thoracic Surgery, 23(3), 486–497. https://doi.org/10.1093/icvts/ivw152

    Article  PubMed  Google Scholar 

  53. Cavalheri, V., & Granger, C. (2017). Preoperative exercise training for patients with non-small cell lung cancer. The Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD012020.pub2

    Article  PubMed  PubMed Central  Google Scholar 

  54. Quist, M., Adamsen, L., Rorth, M., Laursen, J. H., Christensen, K. B., & Langer, S. W. (2015). The impact of a multidimensional exercise intervention on physical and functional capacity, anxiety, and depression in patients with advanced-stage lung cancer undergoing chemotherapy. Integrative Cancer Therapies, 14(4), 341–349. https://doi.org/10.1177/1534735415572887

    Article  CAS  PubMed  Google Scholar 

  55. Sommer, M. S., Vibe-Petersen, J., Stærkind, M. B., Langer, S. W., Larsen, K. R., Trier, K., Christensen, M., Clementsen, P. F., Missel, M., Christensen, K. B., Lillelund, C., Langberg, H., Pedersen, J. H., & Quist, M. (2020). Early initiated postoperative rehabilitation enhances quality of life in patients with operable lung cancer: Secondary outcomes from a randomized trial. Lung Cancer, 146, 285–289. https://doi.org/10.1016/j.lungcan.2020.06.023

    Article  PubMed  Google Scholar 

  56. Vallance, J. K. H., Courneya, K. S., Jones, L. W., & Reiman, T. (2005). Differences in quality of life between non-Hodgkin’s lymphoma survivors meeting and not meeting public health exercise guidelines. Psycho-Oncology, 14(11), 979–991. https://doi.org/10.1002/pon.910

    Article  PubMed  Google Scholar 

  57. Courneya, K. S., Karvinen, K. H., Campbell, K. L., Pearcey, R. G., Dundas, G., Capstick, V., & Tonkin, K. S. (2005). Associations among exercise, body weight, and quality of life in a population-based sample of endometrial cancer survivors. Gynecologic Oncology, 97(2), 422–430. https://doi.org/10.1016/j.ygyno.2005.01.007

    Article  PubMed  Google Scholar 

  58. Stevinson, C., Faught, W., Steed, H., Tonkin, K., Ladha, A. B., Vallance, J. K., Capstick, V., Schepansky, A., & Courneya, K. S. (2007). Associations between physical activity and quality of life in ovarian cancer survivors. Gynecologic Oncology, 106(1), 244–250. https://doi.org/10.1016/j.ygyno.2007.03.033

    Article  PubMed  Google Scholar 

  59. Walker, J., Hansen, C. H., Martin, P., Symeonides, S., Ramessur, R., Murray, G., & Sharpe, M. (2014). Prevalence, associations, and adequacy of treatment of major depression in patients with cancer: a cross-sectional analysis of routinely collected clinical data. The Lancet Psychiatry, 1(5), 343–350. https://doi.org/10.1016/S2215-0366(14)70313-X

    Article  PubMed  Google Scholar 

  60. Schuch, F. B., Vancampfort, D., Rosenbaum, S., Richards, J., Ward, P. B., Veronese, N., Solmi, M., Cadore, E. L., & Stubbs, B. (2016). Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias. Brazilian Journal of Psychiatry, 38(3), 247–254. https://doi.org/10.1590/1516-4446-2016-1915

    Article  PubMed  PubMed Central  Google Scholar 

  61. Dinas, P. C., Koutedakis, Y., & Flouris, A. D. (2010). Effects of exercise and physical activity on depression. Irish Journal of Medical Science, 180(2), 319–325. https://doi.org/10.1007/S11845-010-0633-9

    Article  PubMed  Google Scholar 

  62. Hartvig, P., Aulin, J., Hugerth, M., Wallenberg, S., & Wagenius, G. (2016). Fatigue in cancer patients treated with cytotoxic drugs: Http: //Dx.Doi.Org/https://doi.org/10.1177/1078155206070774, 12(3), 155–164. https://doi.org/10.1177/1078155206070774

  63. Meneses-Echávez, J. F., González-Jiménez, E., & Ramírez-Vélez, R. (2015). Supervised exercise reduces cancer-related fatigue: a systematic review. Journal of Physiotherapy, 61(1), 3–9. https://doi.org/10.1016/j.jphys.2014.08.019

    Article  PubMed  Google Scholar 

  64. Puetz, T. W., & Herring, M. P. (2012). Differential effects of exercise on cancer-related fatigue during and following treatment: a meta-analysis. American Journal of Preventive Medicine, 43(2), e1. https://doi.org/10.1016/j.amepre.2012.04.027

    Article  PubMed  Google Scholar 

  65. R, H., P, K., EJ, C., MB, F., BJ, P., J, B., & JS, O. (2011). Fatigue and functional impairment in early-stage non-small cell lung cancer survivors. Journal of Pain and Symptom Management, 41(2), 426–435. https://doi.org/10.1016/J.JPAINSYMMAN.2010.05.017

    Article  Google Scholar 

  66. Coups, E. J., Park, B. J., Feinstein, M. B., Steingart, R. M., Egleston, B. L., Wilson, D. J., & Ostroff, J. S. (2010) The Cancer Trajectory and Associations with Quality of Life. 18(2), 664–672 Doi: https://doi.org/10.1158/1055-9965.EPI-08-0589.Physical

  67. B, M., D, C., D, D., K, M., E, M., & Y, L. (2015). Pulmonary rehabilitation for chronic obstructive pulmonary disease. The Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD003793.PUB3

    Article  Google Scholar 

  68. Campbell, K. L., Winters-Stone, K. M., Patel, A., & v., Gerber, L. H., Matthews, C. E., May, A. M., Stuiver, M. M., Stout, N. L., Schmitz, K. H., & Morris, G. S. (2019). An executive summary of reports from an international multidisciplinary roundtable on exercise and cancer: Evidence, guidelines, and implementation. Rehabilitation Oncology, 37(4), 144–152. https://doi.org/10.1097/01.REO.0000000000000186

    Article  Google Scholar 

  69. Nadler, M. B., Desnoyers, A., Langelier, D. M., & Amir, E. (2019). The Effect of Exercise on quality of life, fatigue, physical function, and safety in advanced solid tumor cancers: a meta-analysis of randomized control trials. Journal of Pain and Symptom Management, 58(5), 899-908.e7. https://doi.org/10.1016/j.jpainsymman.2019.07.005

    Article  PubMed  Google Scholar 

  70. Lemanne, D., Cassileth, B., & Gubili, J. (2013). The role of physical activity in cancer prevention, treatment, recovery, and survivorship. ONCOLOGY (United States), 27(6), 580–586.

    Google Scholar 

  71. Thraen-Borowski, K. M., Gennuso, K. P., & Cadmus-Bertram, L. (2017). Accelerometer-derived physical activity and sedentary time by cancer type in the United States. PLoS ONE, 12(8), 1–12. https://doi.org/10.1371/journal.pone.0182554

    Article  CAS  Google Scholar 

  72. Troeschel, A. N., Leach, C. R., Shuval, K., Stein, K. D., Patel, A., & v. (2018). Physical activity in cancer survivors during “Re-Entry” following cancer treatment. Preventing Chronic Disease, 15(5), 1–10. https://doi.org/10.5888/pcd15.170277

    Article  Google Scholar 

  73. Cl, G., Cf, M., & L, I., RA, C., K, G., A, M., L, M., M, K., & L, D. (2014). Low physical activity levels and functional decline in individuals with lung cancer. Lung Cancer (Amsterdam, Netherlands), 83(2), 292–299. https://doi.org/10.1016/J.LUNGCAN.2013.11.014

    Article  Google Scholar 

  74. Christine, M., & S., Ann Scheck, M., Timothy, H., Christine, M. S., Scheck, M. A., & Timothy, H. (2019). Odds of meeting physical activity guidelines by cancer history: updated results from the health information national trends survey (HINTS). Journal of Family Medicine and Disease Prevention. https://doi.org/10.23937/2469-5793/1510112

    Article  Google Scholar 

  75. Sweegers, M. G., Boyle, T., Vallance, J. K., Chinapaw, M. J., Brug, J., Aaronson, N. K., D’Silva, A., Kampshoff, C. S., Lynch, B. M., Nollet, F., Phillips, S. M., Stuiver, M. M., van Waart, H., Wang, X., Buffart, L. M., & Altenburg, T. M. (2019). Which cancer survivors are at risk for a physically inactive and sedentary lifestyle? Results from pooled accelerometer data of 1447 cancer survivors. International Journal of Behavioral Nutrition and Physical Activity, 16(1), 1–15. https://doi.org/10.1186/s12966-019-0820-7

    Article  Google Scholar 

  76. Nagamatsu, Y., Maeshiro, K., Kimura, N. Y., Nishi, T., Shima, I., Yamana, H., & Shirouzu, K. (2007). Long-term recovery of exercise capacity and pulmonary function after lobectomy. Journal of Thoracic and Cardiovascular Surgery, 134(5), 1273–1278. https://doi.org/10.1016/j.jtcvs.2007.06.025

    Article  PubMed  Google Scholar 

  77. Dyrstad, S. M., Hansen, B. H., Holme, I. M., & Anderssen, S. A. (2014). Comparison of Self-reported versus Accelerometer-Measured Physical Activity. Medicine & Science in Sports & Exercise, 46(1). https://journals.lww.com/acsm-msse/Fulltext/2014/01000/Comparison_of_Self_reported_versus.15.aspx

  78. Billé, A., Buxton, J., Viviano, A., Gammon, D., Veres, L., Routledge, T., Harrison-Phipps, K., Dixon, A., & Minetto, M. A. (2021). Preoperative physical activity predicts surgical outcomes following lung cancer resection. Integrative Cancer Therapies, 20, 153473542097585. https://doi.org/10.1177/1534735420975853

    Article  Google Scholar 

  79. CL, G., B, C., L, D., N, H., P, A., KY, L., & SM, P. (2017). Understanding factors influencing physical activity and exercise in lung cancer: a systematic review. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 25(3), 983–999. https://doi.org/10.1007/S00520-016-3484-8

    Article  Google Scholar 

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Authors and Affiliations

  1. School of Health Sciences, TecnoCampus – University Pompeu Fabra, Avinguda Ernest Lluch 32, 08302, Mataró, Spain

    Peña-Perez Teba & Mur-Gimeno Esther

  2. Research Group in Attention to Chronicity and Innovation in Health (GRACIS) - TecnoCampus, University Pompeu Fabra, Barcelona, Spain

    Mur-Gimeno Esther & Sebio-García Raquel

  3. Department of Rehabilitation - Hospital Clínic (Barcelona), Casanova 160 bis, 08036, Barcelona, Spain

    Sebio-García Raquel

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Teba, PP., Esther, MG. & Raquel, SG. Association between physical activity and patient-reported outcome measures in patients with lung cancer: a systematic review and meta-analysis. Qual Life Res 31, 1963–1976 (2022). https://doi.org/10.1007/s11136-021-03053-3

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