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Quality of life among chronic myeloid leukemia patients in the second-line treatment with nilotinib and influential factors

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Abstract

Purpose

This study aims to evaluate the quality of life (QoL) of chronic myeloid leukemia (CML) patients prescribed with nilotinib as a second-line therapy and explores the influential factors.

Methods

A multicenter retrospective survey was conducted via face-to-face interviews based on the EORTC QLQ-C30 questionnaire. A total of 121 adult CML patients resistant to imatinib and used nilotinib for at least 3 months were enrolled. The influential features were assessed by multiple linear regression models.

Results

Patients had the mean age of 47.49 (SD = 13.67) years, dominated by middle-aged and male groups. The mean scores of functions ranged from 75 to 83, and those of symptoms were from 5 to 28, with the highest of fatigue (28.28), insomnia (22.87), and pain (21.07). The mean global health status/QoL score was 67.70 (SD = 16.80) with considerable financial difficulties (52.34 (SD = 32.15)). Male patients reported higher functional scores and fewer symptoms compared with female patients. All aspects of QoL became worse with increasing age. Besides age and gender, level of education, duration of nilotinib usage, and comorbidities were also significantly influential factors in many QoL domains. A predicted model for expected mean scores of QoL domains was built based on these factors.

Conclusions

The CML patients treated with nilotinib had the above-moderate QoL scores, a light decrease of functional scores, great financial difficulties, and still experienced symptoms. Strategies and more therapeutic considerations to enhance QoL for CML patients targeted toward women, the old, low educational level, and long duration of nilotinib usage, and many comorbidities are needed in the setting.

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Data availability

The data supporting the results of this study are available from the corresponding author.

Code availability

The R freeware Version 3.5.1 was used for statistical analysis in this study.

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Acknowledgements

The authors gratefully thank the Boards of Director of National Institute of Hematology and Blood Transfusion and Blood Transfusion Hematology Hospital in Ho Chi Minh City for allowing and facilitating to recruit and interview patients in the hospitals.

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This research did not receive any funding for the conduct and/or preparation.

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Authors and Affiliations

  1. Department of Pharmaceutical Administration and Economics, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi, Vietnam

    Cuc Thi Thu Nguyen & Binh Thanh Nguyen

  2. School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Marche, Italy

    Fabio Petrelli, Stefania Scuri & Iolanda Grappasonni

  3. Department of Organization and Drug Administration, Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam

    Thuy Thi Thu Nguyen

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  1. Cuc Thi Thu Nguyen
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Nguyen, C.T.T., Nguyen, B.T., Nguyen, T.T.T. et al. Quality of life among chronic myeloid leukemia patients in the second-line treatment with nilotinib and influential factors. Qual Life Res 31, 733–743 (2022). https://doi.org/10.1007/s11136-021-02952-9

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