Abstract
Background
Health-related quality of life (HRQoL) is an important indicator when evaluating prognosis and disease-related treatments. Our current knowledge of the HRQoL outcomes of unruptured intracranial aneurysm (UIA) patients treated by the endovascular intervention appeared to be very limited. To fill this gap, the present study investigated the HRQoL outcomes and identified the influencing factors in UIA patients treated by endovascular intervention.
Methods
We conducted a single-center cross-sectional study on patients who underwent endovascular treatment for UIAs. HRQoL outcomes were assessed by the 36-item Short Form Health Survey (SF-36). The SF-36 results of the Chinese reference population were used as the reference data. The independent variables with a univariate analysis result of P < 0.05 were included in the multivariate analysis. Finally, multivariable linear regression analysis was performed to identify the factors influencing HRQoL. Bonferroni correction was utilized for multiple testing correction.
Results
A total of 200 patients (83 males and 117 females, mean age of 55.2 ± 9.48 years) with UIAs treated by endovascular intervention were enrolled. The scores of SF-36 in 8 domains for UIA patients treated by endovascular intervention did not all reach the average level of the Chinese reference population after an average recovery period of 30.67 ± 8.6 months. Ischemic cerebrovascular disease history, advanced age, and mRS progression at discharge were independent risk factors of HRQoL for UIA patients treated by endovascular intervention, but physical exercise at least once a week and daily sleep time no < 6 h were independent protective factors.
Conclusion
The HRQoL of UIA patients treated by the endovascular intervention was decreased to varying degrees compared with those of the Chinese reference population. The influencing factors of HRQoL explored by this study provide insights for improving the clinical management and daily lives of these patients. HRQoL assessment should be included in future aneurysm prognostic studies to provide better evidence.
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Acknowledgements
We want to thank all the patients for their participation in this research.
Funding
This work was supported by the National Key R&D program of China with Grant 2016YFC1300800 and the Beijing Municipal Administration of Hospitals’ Ascent Plan with Grant DFL20180801.
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Participants indicated their agreement to participate in the study via the electronic informed consent included in the survey form. This study was approved by the institutional ethics committee (Xuanwu Hospital, No. 2017082).
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Zhai, XD., Ma, YJ., Yu, JX. et al. Health-related quality of life outcomes and influencing factors in patients with unruptured intracranial aneurysms after endovascular treatment. Qual Life Res 30, 2843–2852 (2021). https://doi.org/10.1007/s11136-021-02904-3
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DOI: https://doi.org/10.1007/s11136-021-02904-3