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Prospective analysis of disability and quality of life in patients with chronic inflammatory demyelinating polyradiculoneuropathy

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A Correction to this article was published on 13 May 2021

This article has been updated

Abstract

Purpose

Even treated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) continues to pose a significant burden in patients’ everyday functioning and may continuously affect their quality of life (QoL). The aims of our prospective study were to analyze health-related QoL in CIDP patients during a 1-year follow-up period in real-life settings and to compare QoL changes with changes in disability and with patient impression of change.

Methods

The study comprised 59 patients diagnosed with CIDP. SF-36 questionnaire was applied in order to evaluate patients’ QoL. Inflammatory neuropathy cause and treatment (INCAT) disability scale was used to assess patients’ functionality. The second question from the SF-36 questionnaire was used as an estimation of the patient impression of change (PIC) after 1 year.

Results

SF-36 scores did not change over time in the group as a whole. According to INCAT disability scores, worsening was registered in 24 (40%) patients and improvement in 8 (14%). Fifteen (25%) patients reported worsening and the same number reported improvement, according to PIC. Concordant results on INCAT and PIC were registered in 49% of patients. Pooled SF-36 scores moderately correlated with pooled INCAT disability scores (rho = − 0.27 to − 0.59, p < 0.01). One-year changes of SF-36 scores did not differ when compared to different INCAT outcomes (worsening, stable, improvement). On the other hand, significant changes of SF-36 scores in different outcome groups according to PIC (worsening, stable, improvement) were noted (p < 0.01).

Conclusion

INCAT, PIC, and SF-36 are complementary outcome measures that provide neurologists with useful items of information. We propose complementary use of these scales in CIDP patients in everyday clinical practice in order to detect worsening of the disease and/or of related symptoms on time.

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Availability of data and materials

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

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Funding

This study was supported by the Ministry of Education, Science and Technological Development of Serbia (Grant #175083).

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Authors and Affiliations

  1. Neurology Clinic, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, 6, Dr. Subotic Sr. Street, 11 000, Belgrade, Serbia

    Ivo Bozovic, Aleksa Palibrk, Stojan Peric & Ivana Basta

  2. Institute for Health Protection of Mother and Child of Serbia “Dr. Vukan Cupic”, Belgrade, Serbia

    Marina Peric

  3. Faculty of Medical Sciences, Department of Neurology, University of Kragujevac, Kragujevac, Serbia

    Ana Arsic Azanjac & Dejan Aleksic

  4. Neurology Clinic, Clinical Center of Montenegro, Podgorica, Montenegro

    Ivana Bulatovic

Authors
  1. Ivo Bozovic
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  2. Marina Peric
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  3. Ana Arsic Azanjac
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  4. Aleksa Palibrk
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  5. Ivana Bulatovic
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  6. Dejan Aleksic
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  7. Stojan Peric
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  8. Ivana Basta
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Ivo Bozovic, Marina Peric, Ivana Bulatovic, Ana Azanjac Arsic, Aleksa Palibrk, and Dejan Aleksic. The first draft of the manuscript was written by Stojan Peric and Ivo Bozovic, and all authors have commented on previous versions of the manuscript. The whole research was conceptualized and supervised by Ivo Bozovic, Stojan Peric, and Ivana Basta. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Ivana Basta.

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The authors declare that they have no conflict of interest.

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Ethical approval

This research was approved by the Ethical Board of the Neurology Clinic, Clinical Center of Serbia.

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The original online version of this article was revised: Affiliation number 3 is updated.

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Bozovic, I., Peric, M., Arsic Azanjac, A. et al. Prospective analysis of disability and quality of life in patients with chronic inflammatory demyelinating polyradiculoneuropathy. Qual Life Res 30, 2573–2579 (2021). https://doi.org/10.1007/s11136-021-02838-w

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  • DOI: https://doi.org/10.1007/s11136-021-02838-w

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