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Health-related quality of life among pulmonary tuberculosis patients in Pakistan

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Abstract

Purpose

Health-related quality of life (HRQoL) of pulmonary TB patients has not been assessed in Pakistan. We assessed self-reported HRQoL of pulmonary TB patients in Karachi, Pakistan utilizing the EQ-5D and EQ-VAS prior to, during, and after completion of TB treatment.

Methods

We enrolled 226 pulmonary TB patients in a longitudinal cohort study. Health-utility scores were estimated by the EQ-5D five dimensions and the EQ-Visual Analogue Scale (VAS) at baseline (month 0) and each monthly follow-up visit until treatment completion at month 6. Repeated-measures ANOVA was used to investigate effect of time into treatment on EQ-5D and EQ-VAS scores.

Results

EQ-5D health utility and EQ-VAS scores increase with treatment progression. For the enrolled TB patients, the mean EQ-5D utility scores more than doubled from 0.43 to 0.88, p < .001, effect size η2 = 0.40 from treatment initiation to treatment completion.

Conclusion

Perceived HRQoL of TB patients improves with treatment progression. This can inform targeted treatment plans as well as TB policy and funding for high-burden countries.

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Authors and Affiliations

  1. Global Health Directorate, Indus Health Network, Karachi, Pakistan

    Saniya Saleem, Amyn A. Malik, Asma Ghulam & Junaid Ahmed

  2. Interactive Research and Development, Karachi, Pakistan

    Amyn A. Malik & Hamidah Hussain

Authors
  1. Saniya Saleem
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  2. Amyn A. Malik
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  3. Asma Ghulam
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  4. Junaid Ahmed
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  5. Hamidah Hussain
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Corresponding author

Correspondence to Saniya Saleem.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Saleem, S., A. Malik, A., Ghulam, A. et al. Health-related quality of life among pulmonary tuberculosis patients in Pakistan. Qual Life Res 27, 3137–3143 (2018). https://doi.org/10.1007/s11136-018-1954-9

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  • DOI: https://doi.org/10.1007/s11136-018-1954-9

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