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Determinants of quality of life among long-term breast cancer survivors

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Abstract

Purpose

To identify the impact of clinical and socio-economic determinants on quality of life (QoL) among breast cancer (BC) survivors 5 years after diagnosis.

Methods

A cross-sectional survey was conducted in women diagnosed in 2007 for primary invasive non-metastatic BC and identified through the Côte d’Or BC registry. QoL was assessed with the Medical Outcomes Study 12-item Short Form Health Survey (SF-12), the European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30) and the breast cancer (EORTC-QLQ-BR23) questionnaires. Social support was assessed with Sarason’s social support questionnaire, and deprivation was assessed by the EPICES questionnaire. Clinical variables were collected through the registry database. Determinants of QoL were identified using multivariable mixed model analysis for each SF-12 dimension. A sensitivity analysis was conducted with multiple imputations on missing data.

Results

Overall, 188 patients on 319 patients (59 %) invited to participate to the survey completed the questionnaires. Five years after breast cancer diagnosis, the disease stages at diagnosis, as well as the treatment received, were not determinants of QoL. Only the age at diagnosis and comorbidities were found to be determinants of QoL.

Conclusions

Five years after BC diagnosis, disease severity and the treatment received did not affect QoL.

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Acknowledgments

We thank Ludovic Bouzigues for data collection and Philip Bastable, for correcting the manuscript.

Author information

Authors and Affiliations

  1. Breast and Gynaecologic Cancer Registry of Côte d’Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France

    Wai-on Chu, Pegdwende Olivia Dialla, Marie-Laure Poillot & Patrick Arveux

  2. EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France

    Wai-on Chu, Pegdwende Olivia Dialla, Marie-Laure Poillot, Patrick Arveux & Tienhan Sandrine Dabakuyo-Yonli

  3. Pathology Centre, 33 rue Nicolas Bornier, 21000, Dijon, France

    Patrick Roignot

  4. Centre Radiotherapie du Parc, 18 cours du General de Gaulle, 21000, Dijon Cedex, France

    Marie-Christine Bone-Lepinoy

  5. Department of Surgical Oncology, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France

    Charles Coutant

  6. Biostatistics and Quality of Life Unit, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion, BP 77980, 21079, Dijon Cedex, France

    Tienhan Sandrine Dabakuyo-Yonli

  7. National Quality of Life and Cancer Clinical Research Platform, Dijon, France

    Tienhan Sandrine Dabakuyo-Yonli

Authors
  1. Wai-on Chu
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  2. Pegdwende Olivia Dialla
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  3. Patrick Roignot
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  4. Marie-Christine Bone-Lepinoy
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  5. Marie-Laure Poillot
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  6. Charles Coutant
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  7. Patrick Arveux
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  8. Tienhan Sandrine Dabakuyo-Yonli
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Corresponding author

Correspondence to Tienhan Sandrine Dabakuyo-Yonli.

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Ethical approval

Côte d’Or breast and gynaecological cancer registry has agreement of “Commission Nationale de l’Informatique et des Libertés (CNIL)” DR-2012-038 for collecting data, recording data and carrying out studies with these data.

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Chu, Wo., Dialla, P.O., Roignot, P. et al. Determinants of quality of life among long-term breast cancer survivors. Qual Life Res 25, 1981–1990 (2016). https://doi.org/10.1007/s11136-016-1248-z

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  • DOI: https://doi.org/10.1007/s11136-016-1248-z

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