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Apple Phenolic Extracts Strongly Inhibit α-Glucosidase Activity

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Abstract

The beneficial health effects of apple consumption are well known, however, little is known about the potential of its phenolic fractions to inhibit α-glucosidases and thereafter to treat diseases related to the carbohydrate metabolism, such as postprandial hyperglycemia and diabetes. In the present study, the α-glucosidase inhibition and antioxidant activity of different phenolic fractions of apple were evaluated using the 2,2-diphenyl-1-picrylhydrazyl and hydroxyl radical scavenging activity. Moreover, the phenolic fractions were chemically characterized by LC-MS in order to identify the compounds responsible for the biological properties. The purified extract (not fractionated) had the highest α-glucosidase and hydroxyl radical inhibitions. The purified extract and fractions III and IV were more active against the enzyme activity than the positive control acarbose, the drug used by diabetic patients to treat postprandial hyperglycaemia. Our results show that apple phenolic extracts strongly inhibit α-glucosidase acitivity, validating their potential to be used in the management of type 2 diabetes.

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Authors and Affiliations

  1. Department of Agroindustrial Science and Technology, Federal University of Pelotas, Pelotas, RS, 96010-900, Brazil

    Chirle de Oliveira Raphaelli, Elisa dos Santos Pereira, Taiane Mota Camargo, Cesar Valmor Rombaldi & Leonardo Nora

  2. Embrapa Clima Temperado, Pelotas, RS, 96010-971, Brazil

    Juliana Vinholes & Márcia Vizzotto

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  1. Chirle de Oliveira Raphaelli
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  2. Elisa dos Santos Pereira
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  3. Taiane Mota Camargo
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Correspondence to Chirle de Oliveira Raphaelli.

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de Oliveira Raphaelli, C., dos Santos Pereira, E., Camargo, T.M. et al. Apple Phenolic Extracts Strongly Inhibit α-Glucosidase Activity. Plant Foods Hum Nutr 74, 430–435 (2019). https://doi.org/10.1007/s11130-019-00757-3

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