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Investigation of the Potential Health Benefits as Lipase Inhibitor and Antioxidant of Leopoldia comosa (L.) Parl.: Variability of Chemical Composition of Wild and Cultivated Bulbs

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Abstract

There is a great interest in the nutritional value of vegetables and fruits and how the habitat affects nutritive and biological properties. In vitro studies here reported were performed to evaluate the inhibitory activity of formulations from edible plant on pancreatic lipase. The aim of this study was also to evaluate the biovariability of L. comosa (L.) Parl. bulbs from Italy. The wild bulbs were compared with the same cultivated species that are commonly commercialized to identify samples with the best quality for a potential therapeutic application. Hydroalcoholic extract and polar fraction of wild bulbs showed a very important pancreatic lipase inhibitory activity, with IC50 values of 0.166 ± 0.005 and 0.153 ± 0.005 mg/mL, respectively. In order to characterize the extracts, gas chromatography associated with mass spectrometry (GC/MS) analysis was performed, revealing the predominance of palmitic acid. Phenolic and flavonoid composition was also evaluated. L. comosa extract obtained from wild bulbs demonstrated both antioxidant and anti-obesity activities that might be attributed to a wide range of present phenolic compounds.

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Authors and Affiliations

  1. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, I-87036, Rende, CS, Italy

    Mariangela Marrelli, Stefania La Grotteria & Filomena Conforti

  2. Department of AGRARIA, University “Mediterranea” of Reggio Calabria, I-89100, Reggio Calabria, Italy

    Fabrizio Araniti

Authors
  1. Mariangela Marrelli
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  2. Stefania La Grotteria
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  3. Fabrizio Araniti
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  4. Filomena Conforti
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Corresponding author

Correspondence to Filomena Conforti.

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Electronic supplementary material

Online Resource 1

Materials and Methods (PDF 113 kb)

Online Resource 2

Yield% of extractions of Leopoldia comosa (L.) Parl. hydroalcoholic extracts and fraction. (PDF 52 kb)

Online Resource 3

Total phenolic (TP) and flavonoid (TF) content of Leopoldia comosa (L.) Parl. hydroalcoholic extracts. Total phenolics (TP) were expressed as chlorogenic acid equivalents in mg per g of crude extract. Total flavonoids (TF) were expressed as quercetin equivalents in mg per g of raw extract. Results are expressed as mean ± SD (n = 3). (PDF 276 kb)

Online Resource 4

Statistically significant features identified through t-test. (PDF 49 kb)

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Marrelli, M., La Grotteria, S., Araniti, F. et al. Investigation of the Potential Health Benefits as Lipase Inhibitor and Antioxidant of Leopoldia comosa (L.) Parl.: Variability of Chemical Composition of Wild and Cultivated Bulbs. Plant Foods Hum Nutr 72, 274–279 (2017). https://doi.org/10.1007/s11130-017-0618-1

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  • DOI: https://doi.org/10.1007/s11130-017-0618-1

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