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The role of forkhead-associated (FHA)-domain proteins in plant biology

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Abstract

The forkhead-associated (FHA) domain, a well-characterized small protein module that mediates protein–protein interactions by targeting motifs containing phosphothreonine, is present in many regulatory molecules like protein kinase, phosphatases, transcription factors, and other functional proteins. FHA-domain containing proteins in yeast and human are involved in a large variety of cellular processes such as DNA repair, cell cycle arrest, or pre-mRNA processing. Since the first FHA-domain protein, kinase-associated protein phosphatase (KAPP) was found in plants, the interest in plant FHA-containing proteins has increased dramatically, mainly due to the important role of FHA domain-containing proteins in plant growth and development. In this review, we provide a comprehensive overview of the fundamental properties of FHA domain-containing proteins in plants, and systematically summarized and analyzed the research progress of proteins containing the FHA domain in plants. We also emphasized that AT5G47790 and its homologs may play an important role as the regulatory subunit of protein phosphatase 1 (PP1) in plants.

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Acknowledgements

This work is funded by the Science-Technology Foundation for Young Scientists of Gansu Province, China (22JR5RA524) and the China Postdoctoral Science Foundation (2022M721435).

Funding

Funding was provided by Science-Technology Foundation for Young Scientists of Gansu Province, China (22JR5RA524) and the China Postdoctoral Science Foundation (2022M721435).

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Authors and Affiliations

  1. Institute of Future Agriculture, State Key Laboratory of Crop Stress Biology for Arid Areas, State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling, 712100, Shaanxi, People’s Republic of China

    Qiuling Wang

  2. Key Laboratory of Cell Activities and Stress Adaptations, Ministry of Education, School of Life Sciences, Lanzhou University, Lanzhou, 730000, People’s Republic of China

    Qiuling Wang

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  1. Qiuling Wang
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QW designed and conceived the review, analyzed the literature, and drafted the manuscript.

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Wang, Q. The role of forkhead-associated (FHA)-domain proteins in plant biology. Plant Mol Biol 111, 455–472 (2023). https://doi.org/10.1007/s11103-023-01338-4

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