Abstract
Endothelial dysfunction, characterized by impaired endothelial function, is critical in developing cardiovascular diseases. Emerging evidence suggests that certain constituents of commonly used spices potentially mitigate endothelial dysfunction. This review summarizes the current literature on the constituents of commonly used spices and their molecular interactions in endothelial system. We first provide an overview of physiological significance as well as dysfunction of endothelium and its role in cardiovascular diseases, including the mechanisms like oxidative stress, inflammation, atherosclerosis, hypertension, thrombosis, and impaired nitric oxide (NO) bioavailability. The physiological significance such as, regulation of thrombosis and fibrinolysis, preventing atherosclerosis and neo-angiogenesis, were discussed. Various spices reported to possess vascular-targeting properties, including curcumin from turmeric, allicin from garlic, gingerol from ginger, piperine from black pepper, quercetin from onion, 2-methoxycinnamaldehyde from cinnamon etc. were discussed. We highlight the molecular interactions of these spice constituents with endothelial cells, including their effects on oxidative stress, inflammation, atherosclerosis, thrombosis, and NO bioavailability. Evidence from in vitro, animal, and human studies reveals that, spice constituents modulate various signaling pathways and enhance NO bioavailability, which collectively contribute to their potential beneficial effects on endothelial function. Furthermore, we discuss the potential mechanisms including reduced expression of ICAM, VCAM, and selectin, inhibition of NF-κB activation and translocation, and decreased ROS and H2O2 levels. In conclusion, the constituents of commonly used spices, such as (allicin, curcumin, quercetin, gingerol etc.) promises a novel approach for modulating endothelial function in vascular disorders. Further research in this area may provide valuable insights into the potential use of these spice constituents as complementary or alternative therapies for cardiovascular diseases.
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Abbreviations
- ADP:
-
Adenosine Di-Phosphate
- cPLA2 :
-
Cytosolic Phospholipase A2
- ECs:
-
Endothelial Cells
- eNOS:
-
Endothelial Nitric Oxide Synthase
- HCAEC:
-
Human Coronary Artery Endothelial Cells
- HCAEc:
-
Human Coronary Artery Endothelial Cells
- HIMEC:
-
Human Intestinal Microvascular Endothelial Cell
- ICAM:
-
Intercellular Adhesion Molecule
- IL-1:
-
Interleukin 1
- IκB:
-
Inhibitory κ B Protein
- PGI2 :
-
Prostaglandin I2
- PKC:
-
Protein Kinase C
- TNFα:
-
Tumour Necrosis Factor α
- VEGFR-2:
-
Vascular Endothelial Growth Factor Receptor 2
References
Abdel-Wahhab KG, Fawzi H, Mannaa FA (2016) Paraoxonase-1 (PON1) inhibition by tienilic acid produces hepatic injury: antioxidant protection by fennel extract and whey protein concentrate. Pathophysiology 23:19–25. https://doi.org/10.1016/J.PATHOPHYS.2015.10.002
Abolaji AO, Ojo M, Afolabi TT et al (2017) Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats. Chem Biol Interact 270:15–23. https://doi.org/10.1016/J.CBI.2017.03.017
Afify AEMMR, El-Beltagi HS, Hammama AAEA et al (2011) Distribution of trans-anethole and estragole in fennel (Foeniculum vulgare Mill) of callus induced from different seedling parts and fruits. Not Sci Biol 3:79–86. https://doi.org/10.15835/NSB315422
Aged garlic extract modulates glutathione redox cycle and superoxide dismutase activity in vascular endothelial cells—Geng—1997—Phytotherapy Research - Wiley Online Library. https://doi.org/10.1002/(SICI)1099-1573(199702)11:1%3C54::AID-PTR950%3E3.0.CO;2-Y. Accessed 20 Oct 2022
Ahmad N, Fazal H, Abbasi BH et al (2012) Biological role of Piper nigrum L. (Black pepper): a review. Asian Pac J Trop Biomed. https://doi.org/10.1016/S2221-1691(12)60524-3
Ahmad R, Rahman T, Froemming GA, Nawawi H (2016) Anti-oxidant properties of fenugreek and saponins, and their effects on eNOS expression on human coronary artery endothelial cells. Atherosclerosis 252:e158. https://doi.org/10.1016/J.ATHEROSCLEROSIS.2016.07.763
Aissaoui A, El-Hilaly J, Israili ZH, Lyoussi B (2008) Acute diuretic effect of continuous intravenous infusion of an aqueous extract of Coriandrum sativum L. in anesthetized rats. J Ethnopharmacol 115:89–95. https://doi.org/10.1016/J.JEP.2007.09.007
Akram M, Rashid A (2017) Anti-coagulant activity of plants: mini review. J Thromb Thrombolysis 44:406–411. https://doi.org/10.1007/S11239-017-1546-5
Al-Asadi JN (2014) Therapeutic uses of fenugreek (Trigonella foenum-graecum L.) Open access
Ali SS, Kasoju N, Luthra A et al (2008) Indian medicinal herbs as sources of antioxidants. Food Res Int 41:1–15. https://doi.org/10.1016/J.FOODRES.2007.10.001
Alpsoy S, Uygur R, Aktas C et al (2013) The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells. J Appl Toxicol 33:364–369. https://doi.org/10.1002/JAT.1750
Ammon HPT, Wahl MA (1991) Pharmacology of Curcuma longa. Planta Med 57:1–7. https://doi.org/10.1055/S-2006-960004/BIB
An Update Review of Saffron and its Active Constituents—Ríos—1996—Phytotherapy Research—Wiley Online Library. https://doi.org/10.1002/(SICI)1099-1573(199605)10:3%3C189::AID-PTR754%3E3.0.CO;2-C. Accessed 17 Nov 2022
Baba K, Xiao YQ, Taniguchi M et al (1991) Isocoumarins from Coriandrum sativum. Phytochemistry 30:4143–4146. https://doi.org/10.1016/0031-9422(91)83482-Z
Badgujar SB, Patel VV, Bandivdekar AH (2014) Foeniculum vulgare Mill: a review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. Biomed Res Int. https://doi.org/10.1155/2014/842674
Baratta MT, Damien HJ, Deans SG et al (2011) Chemical composition, antimicrobial and antioxidative activity of laurel, sage, rosemary, oregano and coriander essential oils. J Essent Oil Res 10:618–627. https://doi.org/10.1080/10412905.1998.9700989
Bardai SE, Lyoussi B, Wibo M, Morel N (2001) Pharmacological evidence of hypotensive activity of marrubium vulgare and foeniculum vulgare in spontaneously hypertensive rat. Clin Exp Hypertens 23:329–343. https://doi.org/10.1081/CEH-100102671
Barnes PJ, Karin M (1997) Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066–1071. https://doi.org/10.1056/NEJM199704103361506
Bedi PS, Singh H, Singh B (2012) Effects of garlic against 7–12, dimethyl benzanthracene induced toxicity in Wistar albino rats anticancer activity view project medicinal plants view project hepatoprotective activity of turmeric and garlic against 7–12, dimethylbenzanthracene induced liver damage in wistar albino rats. Asian J Pharm Clin Res 1:162–170
Bernard MM, McConnery JR, Hoskin DW (2017) [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Exp Mol Pathol 102:370–376. https://doi.org/10.1016/J.YEXMP.2017.03.006
Binion DG, Heidemann J, Li MS et al (2009) Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin. Am J Physiol Gastrointest Liver Physiol. https://doi.org/10.1152/AJPGI.00087.2009
Böger RH, Bode-Böger SM, Thiele W et al (1997) Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation 95:2068–2074. https://doi.org/10.1161/01.CIR.95.8.2068
Butt MS, Sultan MT (2011) Ginger and its health claims: molecular aspects. Crit Rev Food Sci Nutr 51:383–393. https://doi.org/10.1080/10408391003624848
Cai X, Bao L, Ding Y et al (2017) Quercetin alleviates cell apoptosis and inflammation via the ER stress pathway in vascular endothelial cells cultured in high concentrations of glucosamine. Mol Med Rep 15:825–832. https://doi.org/10.3892/MMR.2016.6054/HTML
Ceska O, Chaudhary SK, Warrington P et al (1988) Coriandrin, a novel highly photoactive compound isolated from Coriandrum sativum. Phytochemistry 27:2083–2087. https://doi.org/10.1016/0031-9422(88)80101-8
Chainani-Wu N (2004) Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Alternat Complement Med 9:161–168. https://doi.org/10.1089/107555303321223035
Chang YS, Woo ER (2003) Korean medicinal plants inhibiting to human immunodeficiency virus type 1 (HIV-1) fusion. Phytother Res 17:426–429. https://doi.org/10.1002/PTR.1155
Chaudhary SK, Maity N, Nema NK et al (2013) Angiotensin converting enzyme inhibition activity of fennel and coriander oils from India. Nat Prod Commun 8:671–672. https://doi.org/10.1177/1934578X1300800531
Chavarria D, Silva T, MagalhãesE Silva D et al (2015) Lessons from black pepper: piperine and derivatives thereof. Expert Opin Therap Patents 26:245–264. https://doi.org/10.1517/13543776.2016.1118057
Chen X, Li H, Wang Z et al (2020) Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHII/eNOS/NO pathway. Eur J Pharmacol 868:172885. https://doi.org/10.1016/J.EJPHAR.2019.172885
Chithra V, Leelamma S (1997) Hypolipidemic effect of coriander seeds (Coriandrum sativum): mechanism of action. Plant Foods Hum Nutr 51:167–172. https://doi.org/10.1023/A:1007975430328
Christodoulou E, Kadoglou NP, Kostomitsopoulos N, Valsami G (2015) Saffron: a natural product with potential pharmaceutical applications. J Pharm Pharmacol 67:1634–1649. https://doi.org/10.1111/JPHP.12456
Çifci A, Tayman C, Yakut Hİ et al (2018) Ginger (Zingiber officinale) prevents severe damage to the lungs due to hyperoxia andinflammation. Turk J Med Sci 48:892–900. https://doi.org/10.3906/sag-1803-223
Cines DB, Pollak ES, Buck CA et al (1998) Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91:3527–3561. https://doi.org/10.1182/BLOOD.V91.10.3527
Coban D, Milenkovic D, Chanet A et al (2012) Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. Mol Nutr Food Res 56:1270–1281. https://doi.org/10.1002/MNFR.201100818
Collins T, Read MA, Neish AS et al (1995) Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J 9:899–909. https://doi.org/10.1096/FASEBJ.9.10.7542214
Consoli RA, Mendes NM, Pereira JP et al (1988) Effect of several extracts derived from plants on the survival of larvae of Aedes fluviatilis (Lutz) (Diptera: Culicidae) in the laboratory. Mem Inst Oswaldo Cruz 83:87–93. https://doi.org/10.1590/S0074-02761988000100012
da Silva MLT, Bernardo MAS, Singh J, de Mesquita MF (2019) Beneficial uses of cinnamon in health and diseases: an interdisciplinary approach. In: The role of functional food security in global health, pp 565–576. https://doi.org/10.1016/B978-0-12-813148-0.00033-5
Dawud FA, Dubo AB, Yusuf NW, Umar IA (2016) Effects of aqueous extract of Allium cepa (red onion) on ovalbumininduced allergic asthma in wistar rats. Bayero J Pure Appl Sci 9:95–101. https://doi.org/10.4314/bajopas.v9i2.19
de Graaf JC, Banga JD, Moncada S et al (1992) Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions. Circulation 85:2284–2290. https://doi.org/10.1161/01.CIR.85.6.2284
Denninger JW, Marletta MA (1999) Guanylate cyclase and the ⋅NO/cGMP signaling pathway. BBA Bioenerget 1411:334–350. https://doi.org/10.1016/S0005-2728(99)00024-9
Dorri M, Hashemitabar S, Hosseinzadeh H (2018) Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol 41:338–351. https://doi.org/10.1080/01480545.2017.1417995
Douglas G, Channon KM (2014) The pathogenesis of atherosclerosis medicine (United Kingdom). J Am Coll Cardiol 42:480–484. https://doi.org/10.1016/J.MPMED.2014.06.011
Ebnet K, Vestweber D (1999) Molecular mechanisms that control leukocyte extravasation: the selectins and the chemokines. Histochem Cell Biol 112:1–23. https://doi.org/10.1007/S004180050387
Ebrahimzadeh Attari V, Asghari Jafarabadi M, Zemestani M, Ostadrahimi A (2015) Effect of Zingiber officinale supplementation on obesity management with respect to the uncoupling protein 1–3826A>G and ß3-adrenergic receptor Trp64Arg polymorphism. Phytother Res 29:1032–1039. https://doi.org/10.1002/PTR.5343
Emeis JJ (1995) The control of tPA and PAI-1 secretion from the vessel wall. Vasc Med Rev 6:153–166. https://doi.org/10.1177/1358863X9500600208/ASSET/1358863X9500600208.FP.PNG_V03
Esmon CT (2000) The endothelial cell protein C receptor. Thromb Haemost 83:639–643. https://doi.org/10.1055/S-0037-1613883/ID/JR1613883-11
Filomeni G, De Zio D, Cecconi F (2014) Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ 22:377–388. https://doi.org/10.1038/cdd.2014.150
Gong G, Qin Y, Huang W et al (2010) Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis. Chem Biol Interact 184:366–375. https://doi.org/10.1016/J.CBI.2010.02.005
Gupta B, Ghosh B (1999) Curcuma longa inhibits TNF-α induced expression of adhesion molecules on human umbilical vein endothelial cells. Int J Immunopharmacol 21:745–757. https://doi.org/10.1016/S0192-0561(99)00050-8
Gupta D, Lalwani D, Gupta R (2022) Extraction and evaluation of Allium cepa for pharmacological action. GSC Biol Pharm Sci 2022:168–172. https://doi.org/10.30574/gscbps.2022.18.2.0043
Gutiérrez-Grijalva EP, Picos-Salas MA, Leyva-López N et al (2017) Flavonoids and phenolic acids from oregano: occurrence, biological activity and health benefits. Plants 7:2. https://doi.org/10.3390/PLANTS7010002
Han J, Pan XY, Xu Y et al (2012) Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage. Autophagy 8:812–825. https://doi.org/10.4161/AUTO.19471/SUPPL_FILE/KAUP_A_10919471_SM0001.ZIP
Han AY, Lee HS, Seol GH (2016) Foeniculum vulgare Mill. increases cytosolic Ca2+ concentration and inhibits store-operated Ca2+ entry in vascular endothelial cells. Biomed Pharmacother 84:800–805. https://doi.org/10.1016/J.BIOPHA.2016.10.013
Harrison DG (1997) Cellular and molecular mechanisms of endothelial cell dysfunction 2153. J Clin Invest 100:2153–2157
Harrison DG, Venema RC, Arnal JF et al (1995) The endothelial cell nitric oxide synthase: is it really constitutively expressed? Agents Actions Suppl 45:107–117. https://doi.org/10.1007/978-3-0348-7346-8_16
Hecker M, Sessa WC, Harris HJ et al (1990) The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc Natl Acad Sci 87:8612–8616. https://doi.org/10.1073/PNAS.87.21.8612
Helen A, Antony H (2021) Mucilage isolated from fenugreek seeds modulates inflammatory markers of atherosclerosis induced by high cholesterol diet in rabbits. Atherosclerosis 331:e90–e91. https://doi.org/10.1016/j.atherosclerosis.2021.06.263
Huang AJ, Manning JE, Bandak TM et al (1993) Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J Cell Biol 120:1371–1380. https://doi.org/10.1083/JCB.120.6.1371
Hwa JS, Jin YC, Lee YS et al (2012) 2-Methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. J Ethnopharmacol 139:605–615. https://doi.org/10.1016/J.JEP.2011.12.001
Ishikawa T, Yanagisawa M, Kimura S et al (1988) Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide. Pflugers Arch 413:108–110. https://doi.org/10.1007/BF00581239/METRICS
Jabeen Q, Bashir S, Lyoussi B, Gilani AH (2009) Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. J Ethnopharmacol 122:123–130. https://doi.org/10.1016/J.JEP.2008.12.016
Jin ZG, Ueba H, Tanimoto T et al (2003) Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase. Circ Res 93:354–363. https://doi.org/10.1161/01.RES.0000089257.94002.96
Jolad SD, Lantz RC, Solyom AM et al (2004) Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry 65:1937–1954. https://doi.org/10.1016/J.PHYTOCHEM.2004.06.008
Jung HS, Park KH, Cho YM et al (2006) Resistin is secreted from macrophages in atheromas and promotes atherosclerosis. Cardiovasc Res 69:76–85. https://doi.org/10.1016/J.CARDIORES.2005.09.015/2/69-1-76-FIG6.GIF
Kadoglou NPE, Christodoulou E, Kostomitsopoulos N, Valsami G (2021) The cardiovascular-protective properties of saffron and its potential pharmaceutical applications: a critical appraisal of the literature. Phytother Res 35:6735–6753. https://doi.org/10.1002/PTR.7260
Kamato D, Babaahmadi Rezaei H, Getachew R et al (2013) (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. J Pharm Pharmacol 65:1026–1036. https://doi.org/10.1111/JPHP.12060
Karimian MS, Pirro M, Johnston TP et al (2017) Curcumin and endothelial function: evidence and mechanisms of protective effects. Curr Pharm Des. https://doi.org/10.2174/1381612823666170222122822
Kawanami D, Maemura K, Takeda N et al (2004) Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine–endothelial cell interactions. Biochem Biophys Res Commun 314:415–419. https://doi.org/10.1016/J.BBRC.2003.12.104
Kedzierski R (2001) Endothelin system: the double-edged sword in health and disease.
Kharadi GB, Patel KJ, Purohit BM et al (2016) Evaluation of cardioprotective effect of aqueous extract of Allium cepa Linn. bulb on isoprenaline-induced myocardial injury in Wistar albino rats. Res Pharm Sci 11:419. https://doi.org/10.4103/1735-5362.192494
Kim MS, Kim JY (2018) Ginger attenuates inflammation in a mouse model of dextran sulfate sodium-induced colitis. Food Sci Biotechnol 27:1493–1501. https://doi.org/10.1007/S10068-018-0438-6
Kim EC, Min JK, Kim TY et al (2005) [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 335:300–308. https://doi.org/10.1016/J.BBRC.2005.07.076
Kim YS, Ahn Y, Hong MH et al (2006) Curcumin attenuates nuclear factor-κB, c-Jun N-terminal kinase and p38 in tumor necrosis factor-α-stimulated endothelial cells. Korean Circ J 36:482–489. https://doi.org/10.4070/KCJ.2006.36.7.482
Kim J-K, Park J-H, Park GM (2015) Zerumbone, sesquiterpene photochemical from ginger, inhibits angiogenesis. Korean J Physiol Pharmacol 19:335–340. https://doi.org/10.4196/kjpp.2015.19.4.335
Kim HJ, Son JE, Kim JH et al (2018) Gingerenone A attenuates monocyte-endothelial adhesion via suppression of I Kappa B kinase phosphorylation. J Cell Biochem 119:260–268. https://doi.org/10.1002/JCB.26138
Kim NY, Trinh NT, Ahn SG, Kim SA (2020) Cinnamaldehyde protects against oxidative stress and inhibits the TNF-α-induced inflammatory response in human umbilical vein endothelial cells. Int J Mol Med 46:449–457. https://doi.org/10.3892/IJMM.2020.4582/HTML
Kojima S, Ona S, Iizuka I et al (2009) Antioxidative activity of 5,6,7,8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes. Free Radical Res 23:419–430. https://doi.org/10.3109/10715769509065263
Koudela M, Petříková K (2008) Nutritional compositions and yield of sweet fennel cultivars-Foeniculum vulgare Mill. ssp. vulgare var. azoricum (Mill.) Thell. agriculturejournals.cz
Krishna Priya S, Kumar K, Hiran KR et al (2017) Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance. Int J Clin Oncol 22:107–117. https://doi.org/10.1007/S10147-016-1033-6/METRICS
Krishnaswamy G, Kelley J, Yerra L et al (2004) Human endothelium as a source of multifunctional cytokines: molecular regulation and possible role in human disease. J Interferon Cytokine Res 19:91–104. https://doi.org/10.1089/107999099314234
Krüger A, Mrowietz C, Lendlein A, Jung F (2013) Interaction of human umbilical vein endothelial cells (HUVEC) with platelets in vitro: Influence of platelet concentration and reactivity. Clin Hemorheol Microcirc 55:111–120. https://doi.org/10.3233/CH-131695
Krüger-Genge A, Blocki A, Franke R-P, Jung F (2019) Molecular sciences vascular endothelial cell biology: an update
Kubra IR, Rao LJM (2012) An Impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe). Crit Rev Food Sci Nutr 52:651–688. https://doi.org/10.1080/10408398.2010.505689
Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB (1998) Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-κB activation. Biochem Pharmacol 55:775–783. https://doi.org/10.1016/S0006-2952(97)00557-1
Kumar S, Singhal V, Roshan R et al (2007) Piperine inhibits TNF-α induced adhesion of neutrophils to endothelial monolayer through suppression of NF-κB and IκB kinase activation. Eur J Pharmacol 575:177–186. https://doi.org/10.1016/J.EJPHAR.2007.07.056
Kumar MD et al (2014) Phytochemical investigation. Google Scholar. https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Kumar+MD+et+al+%282014%29+Phytochemical+Investigation+and+evaluation+of+antimicrobial+and+antitubercular+activity+of+Kunstleria+Keralensis.+World+J+Pharm+Pharm+Sc+4%282%29%3A465-479&btnG=. Accessed 7 Nov 2022
Kwon H, Lee JJ, Lee JH et al (2015) Cinnamon and its components suppress vascular smooth muscle cell proliferation by up-regulating cyclin-dependent kinase inhibitors. Am J Chin Med 43:621–636. https://doi.org/10.1142/S0192415X1550038X
Lau BHS (2001) Suppression of LDL oxidation by garlic. J Nutr 131:985S-988S. https://doi.org/10.1093/JN/131.3.985S
Lee MJ, Thangada S, Claffey KP et al (1999) Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 99:301–312. https://doi.org/10.1016/S0092-8674(00)81661-X
Lee HS, Lee MJ, Kim H et al (2010) Curcumin inhibits TNFα-induced lectin-like oxidised LDL receptor-1 (LOX-1) expression and suppresses the inflammatory response in human umbilical vein endothelial cells (HUVECs) by an antioxidant mechanism. J Enzyme Inhib Med Chem 25:720–729. https://doi.org/10.3109/14756360903555274
Lee EN, Choi YW, Kim HK et al (2011) Chloroform extract of aged black garlic attenuates TNF-α-induced ROS generation, VCAM-1 expression, NF-κB activation and adhesiveness for monocytes in human umbilical vein endothelial cells. Phytother Res 25:92–100. https://doi.org/10.1002/PTR.3230
Lee HS, Kang P, Kim KY, Seol GH (2015) Foeniculum vulgare mill. Protects against lipopolysaccharide-induced acute lung injury in mice through ERK-dependent NF-kB activation. Korean J Physiol Pharmacol 19:183–189. https://doi.org/10.4196/KJPP.2015.19.2.183
Lee W, Ku SK, Kim MA, Bae JS (2017) Anti-factor Xa activities of zingerone with anti-platelet aggregation activity. Food Chem Toxicol 105:186–193. https://doi.org/10.1016/J.FCT.2017.04.012
Lee YJ, Jang YN, Han YM et al (2018) 6-Gingerol normalizes the expression of biomarkers related to hypertension via PPAR δ in HUVECs, HEK293, and differentiated 3T3-L1 Cells. PPAR Res. https://doi.org/10.1155/2018/6485064
Levine B, Yuan J (2005) Autophagy in cell death: an innocent convict? J Clin Invest 115:2679–2688. https://doi.org/10.1172/JCI26390
Li YP, Gao L, Shi HT et al (2019) Piperine inhibits the transformation of endothelial cells into fibroblasts. Zhonghua Xin Xue Guan Bing Za Zhi 47:554–560. https://doi.org/10.3760/CMA.J.ISSN.0253-3758.2019.07.009
Liu CM, Kao CL, Tseng YT et al (2017a) Ginger phytochemicals inhibit cell growth and modulate drug resistance factors in docetaxel resistant prostate cancer cell. Molecules 22:1477. https://doi.org/10.3390/MOLECULES22091477
Liu D, Wu M, Lu Y et al (2017b) Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells. Biomed Pharmacother 93:788–795. https://doi.org/10.1016/J.BIOPHA.2017.07.037
Lu M, Cao Y, Xiao J et al (2018) Molecular mechanisms of the anti-obesity effect of bioactive ingredients in common spices: a review. Food Funct 9:4569–4581. https://doi.org/10.1039/C8FO01349G
Manduteanu I, Pirvulescu M, Gan AM et al (2010) Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells. Biochem Biophys Res Commun 391:1443–1448. https://doi.org/10.1016/J.BBRC.2009.12.089
Masuda H, Tsuji H (1986) Vascular endothelium nature’s blood container. Vasc Endothel Hemost Thromb 6:1–13. https://doi.org/10.2491/JJSTH.6.31
Medhin DG, Hadhazy P, Bakos P, Verzar-Petri G (1986) Hypotensive effects of Lupinus termis and Coriandrum sativum in anaesthetized rats. A preliminary study. Acta Pharm Hung 56:59–63
Mehta D, Malik AB (2006) Signaling mechanisms regulating endothelial permeability. Physiol Rev 86:279–367. https://doi.org/10.1152/PHYSREV.00012.2005/ASSET/IMAGES/LARGE/Z9J0010623900031.JPEG
Mesfin M, Asres K, Shibeshi W (2014) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice. BMC Complement Altern Med 14:1–7. https://doi.org/10.1186/1472-6882-14-310/TABLES/3
Michiels C (2003) Endothelial cell functions. J Cell Physiol 196:430–443. https://doi.org/10.1002/JCP.10333
Minor RL, Myers PR, Guerra R et al (1990) Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 86:2109–2116. https://doi.org/10.1172/JCI114949
Mohamed OI, Fekry El-Nahas A, Said Y et al (2015) Ginger extract modulates Pb-induced hepatic oxidative stress and expression of antioxidant gene transcripts in rat liver. Pharm Biol 54:1164–1172. https://doi.org/10.3109/13880209.2015.1057651
Mohan CC, Chennazhi KP, Menon D (2013) In vitro hemocompatibility and vascular endothelial cell functionality on titania nanostructures under static and dynamic conditions for improved coronary stenting applications. Acta Biomater 9:9568–9577. https://doi.org/10.1016/J.ACTBIO.2013.08.023
Moncada S, Gryglewski R, Bunting S, Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:663–665. https://doi.org/10.1038/263663a0
Moncada S, Higgs EA, Vane JR (1977) Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. Lancet 309:18–21. https://doi.org/10.1016/S0140-6736(77)91655-5
Moon CH, Jung YS, Kim MH et al (2000) Mechanism for antiplatelet effect of onion: AA release inhibition, thromboxane A2synthase inhibition and TXA2/PGH2receptor blockade. PLEFA 62:277–283. https://doi.org/10.1054/PLEF.2000.0155
Moosa ASM, Rashid MU, Asadi AZS et al (2006) Hypolipidemic effects of fenugreek seed powder. Bangl J Pharmacol 1:64–67. https://doi.org/10.3329/BJP.V1I2.490
Motterlini R, Foresti R, Bassi R, Green CJ (2000) Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 28:1303–1312. https://doi.org/10.1016/S0891-5849(00)00294-X
Mousa AS, Mousa SA (2009) Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutr Cancer 53:104–110. https://doi.org/10.1207/S15327914NC5301_12
Mozaffari-Khosravi H, Talaei B, Jalali BA et al (2014) The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med 22:9–16. https://doi.org/10.1016/J.CTIM.2013.12.017
Muhammad DRA, Dewettinck K (2017) Cinnamon and its derivatives as potential ingredient in functional food—a review. Int J Food Propert 20:2237–2263. https://doi.org/10.1080/10942912.2017.1369102
Muller WA (2002) Leukocyte-endothelial cell interactions in the inflammatory response. Lab Invest 82:521–534. https://doi.org/10.1038/labinvest.3780446
Murugesan M, Revathi R, Manju V (2011) Cardioprotective effect of fenugreek on isoproterenol-induced myocardial infarction in rats. Indian J Pharmacol 43:516. https://doi.org/10.4103/0253-7613.84957
Musenga A, Mandrioli R, Ferranti A et al (2007) Analysis of aromatic and terpenic constituents of pepper extracts by capillary electrochromatography. J Sep Sci 30:612–619. https://doi.org/10.1002/JSSC.200600456
Naama JH, Al-Temimi AA, Al-Amiery AAH (2010) Study the anticancer activities of ethanolic curcumin extract. Afr J Pure Appl Chem 4:68–73
Nair GM, Skaria DS, James T, Kanthlal SK (2019) Clozapine disrupts endothelial nitric oxide signaling and antioxidant system for its cardiovascular complications. Drug Res 69:695–698. https://doi.org/10.1055/A-0991-7684/ID/R2019-07-1869-0010
Nassan MA, Mohamed EH (2016) Immunopathological and antimicrobial effect of black pepper, ginger and thyme extracts on experimental model of acute hematogenous pyelonephritis in albino rats. Crit Rev Food Sci Nutr 27:531–541. https://doi.org/10.1177/039463201402700409
Niempoog S, Pawa KK, Amatyakul C (2012) The efficacy of powdered ginger in osteoarthritis of the knee. J Med Assoc Thai 95:S59-64
Niranjan A, Prakash D (2008) Chemical constituents and biological activities of turmeric (Curcuma longa L.)-a review. J Food Sci Technol Mysore
Nonaka GI, Morimoto S, Nishioka I (1983) Tannins and related compounds. Part 13. Isolation and structures of trimeric, tetrameric, and pentameric proanthicyanidins from cinnamon. J Chem Soc Perkin 1:2139–2145. https://doi.org/10.1039/P19830002139
Ogawa H, Binion DG, Heidemann J et al (2005) Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. Am J Physiol Cell Physiol 288:272–281. https://doi.org/10.1152/AJPCELL.00406.2003/ASSET/IMAGES/LARGE/ZH00020523140006.JPEG
Pakkirisamy M, Kalakandan SK, Ravichandran K (2017) Phytochemical screening, GC-MS, FT-IR analysis of methanolic extract of Curcuma caesia roxb (black turmeric). Pharmacogn J 9:952–956. https://doi.org/10.5530/pj.2017.6.149
Paramdeep G (2013) Efficacy and tolerability of ginger (zingiber officinale) in patients of osteoarthritis of knee
Pearson JD (1999) Endothelial cell function and thrombosis. Best Pract Res Clin Haematol 12:329–341. https://doi.org/10.1053/BEHA.1999.0028
Pearson JD, Carleton JS, Gordon JL (1980) Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture. Biochem J 190:421–429. https://doi.org/10.1042/BJ1900421
Peng X, Cheng KW, Ma J et al (2008) Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts. J Agric Food Chem 56:1907–1911. https://doi.org/10.1021/JF073065V
Pirvulescu MM, Gan AM, Stan D et al (2011) Curcumin and a morus alba extract reduce pro-inflammatory effects of resistin in human endothelial cells. Phytother Res 25:1737–1742. https://doi.org/10.1002/PTR.3463
Pober JS, Sessa WC (2007) Evolving functions of endothelial cells in inflammation. Nat Rev Immunol 7:803–815. https://doi.org/10.1038/NRI2171
Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V (2018) Coriander (Coriandrum sativum): a promising functional food toward the well-being. Food Res Int 105:305–323. https://doi.org/10.1016/J.FOODRES.2017.11.019
Pradeep SR, Srinivasan K (2018) Alleviation of cardiac damage by dietary fenugreek (Trigonella foenum-graecum) seeds is potentiated by onion (Allium cepa) IN EXPERIMENTAL DIABETIC RATS VIA BLOCKING RENIN-ANGIOTENSIN SYSTEm. Cardiovasc Toxicol 18:221–231. https://doi.org/10.1007/S12012-017-9431-1
Prasad Yadav R, Tarun G, Roshan Prasad Yadav C (2017) Versatility of turmeric: a review the golden spice of life. J Pharmacogn Phytochem 6:41–46
Quijia CR, Chorilli M (2019) Characteristics, biological properties and analytical methods of piperine: a review. Crit Rev Anal Chem 50:62–77. https://doi.org/10.1080/10408347.2019.1573656
Rahiman N, Akaberi M, Sahebkar A et al (2018) Protective effects of saffron and its active components against oxidative stress and apoptosis in endothelial cells. Microvasc Res 118:82–89. https://doi.org/10.1016/J.MVR.2018.03.003
Rao PV, Gan SH (2014) Cinnamon: a multifaceted medicinal plant. Evid Based Complement Alternat Med. https://doi.org/10.1155/2014/642942
Rassoul F, Salvetter J, Reissig D et al (2006) The influence of garlic (Allium sativum) extract on interleukin 1α-induced expression of endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Phytomedicine 13:230–235. https://doi.org/10.1016/J.PHYMED.2005.01.010
Rathnawathie M, Buckle KA (1983) Determination of piperine in pepper (Piper nigrum) using high-performance liquid chromatography. J Chromatogr A 264:316–320. https://doi.org/10.1016/S0021-9673(01)95038-1
Rodriguez-Ruiz V, Barzegari A, Zuluaga M et al (2016) Potential of aqueous extract of saffron (Crocus sativus L.) in blocking the oxidative stress by modulation of signal transduction in human vascular endothelial cells. J Funct Foods 26:123–134. https://doi.org/10.1016/J.JFF.2016.07.003
Sadler JE (1997) Thrombomodulin structure and function. Thromb Haemost 78:392–395. https://doi.org/10.1055/S-0038-1657558/ID/JR_11
Sahib NG, Anwar F, Gilani AH et al (2013) Coriander (Coriandrum sativum L.): A potential source of high-value components for functional foods and nutraceuticals—a review. Phytother Res 27:1439–1456. https://doi.org/10.1002/PTR.4897
Sharma OP (1976) Antioxidant activity of curcumin and related compounds. Biochem Pharmacol 25:1811–1812. https://doi.org/10.1016/0006-2952(76)90421-4
Shirooye P, Mokaberinejad R, Ara L, Hamzeloo-Moghadam M (2016) Volatile constituents of ginger oil prepared according to iranian traditional medicine and conventional method: a comparative study. Afr J Tradit Complement Alternat Med 13:68. https://doi.org/10.21010/AJTCAM.V13I6.11
Sidelmann JJ, Gram J, Jespersen J, Kluft C (2000) Fibrin clot formation and lysis: basic mechanisms. Semin Thromb Hemost 26:605–618. https://doi.org/10.1055/S-2000-13216/ID/37
Singh B, Kale RK (2008) Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system. Food Chem Toxicol 46:3842–3850. https://doi.org/10.1016/J.FCT.2008.10.008
Singh AK, Sidhu GS, Deepa T, Maheshwari RK (1996) Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell. Cancer Lett 107:109–115. https://doi.org/10.1016/0304-3835(96)04357-1
Singh Bora K, Sharma A (2009) PHCOG REV.: review article phytoconstituents and therapeutic potential of Allium cepa Linn.-a review. Phcog Rev 3:170–180
Snehlata HS, Payal DR (2012) Fenugreek (Trigonella foenum-graecum L.): an overview. Int J Curr Pharm Rev Res 2: www.ijcpr.com
Son EW, Mo SJ, Rhee DK, Pyo S (2006) Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway. Int Immunopharmacol 6:1788–1795. https://doi.org/10.1016/J.INTIMP.2006.07.021
Song L, Xu M, Lopes-Virella MF, Huang Y (2001) Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys 391:72–78. https://doi.org/10.1006/ABBI.2001.2402
Srinivasan K (2007) Fenugreek (Trigonella foenum-graecum): a review of health beneficial physiological effects. Food Rev Int 22:203–224. https://doi.org/10.1080/87559120600586315
Srivastava KC (1984) Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism. Biomed Biochim Acta 43:S335–S346
Srivastava KC, Bordia A, Verma SK (1995) Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids 52:223–227. https://doi.org/10.1016/0952-3278(95)90040-3
Srivastava P, Sudevan ST, Thennavan A et al (2023) Inhibiting monoamine oxidase in CNS and CVS would be a promising approach to mitigating cardiovascular complications in neurodegenerative disorders. CNS Neurol Disord Drug Targets. https://doi.org/10.2174/1871527322666230303115236
Stern DM, Esposito C, Gerlach H et al (1991) Endothelium and regulation of coagulation. Diabetes Care 14:160–166. https://doi.org/10.2337/DIACARE.14.2.160
Studies on sterol composition of some glyceride oils from family Apiaceae. https://agris.fao.org/agris-search/search.do?recordID=DE96A0847. Accessed 30 Oct 2022
Sukandar EY, Permana H, Adnyana IK et al (2010) Clinical study of turmeric (Curcuma longa L.) and Garlic (Allium sativum L.) extracts as antihyperglycemic and antihyperlipidemic agent in type-2 diabetes-dyslipidemia patients. Int J Pharmacol 6:438–445. https://doi.org/10.3923/IJP.2010.456.463
Syed FQ, Mirza MB, Elkady AI et al (2019) An insight of multitudinous and inveterate pharmacological applications of foeniculum vulgare (fennel). Plant Human Health Pharmacol Therap Uses 3:231–254. https://doi.org/10.1007/978-3-030-04408-4_11
Tailor A, Cooper D, Granger DN (2005) Platelet-vessel wall interactions in the microcirculation. Microcirculation 12:275–285. https://doi.org/10.1080/10739680590925691
Tesauro M, Cardillo C (2011) Obesity, blood vessels and metabolic syndrome. Acta Physiol 203:279–286. https://doi.org/10.1111/J.1748-1716.2011.02290.X
The Chemistry of Garlic and Onions on JSTOR. https://www.jstor.org/stable/24967598. Accessed 20 Oct 2022
Thomson L, Trujillo M, Telleri R, Radi R (1995) Kinetics of cytochrome C2+ oxidation by peroxynitrite: implications for superoxide measurements in nitric oxide-producing biological-systems. Arch Biochem Biophys 319:491–497. https://doi.org/10.1006/ABBI.1995.1321
Tribolo S, Lodi F, Connor C et al (2008) Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells. Atherosclerosis 197:50–56. https://doi.org/10.1016/J.ATHEROSCLEROSIS.2007.07.040
Tzima E, Irani-Tehrani M, Kiosses WB et al (2005) A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 437:426–431. https://doi.org/10.1038/nature03952
UTMQCUVSODM3 »Doc» The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines
Vallverdú-Queralt A, Regueiro J, Martínez-Huélamo M et al (2014) A comprehensive study on the phenolic profile of widely used culinary herbs and spices: rosemary, thyme, oregano, cinnamon, cumin and bay. Food Chem 154:299–307. https://doi.org/10.1016/J.FOODCHEM.2013.12.106
Vasanthi HR, Parameswari PR (2010) Indian spices for healthy heart—an overview. Curr Cardiol Rev 6:274. https://doi.org/10.2174/157340310793566172
Vazquez-Prieto MA, Rodriguez Lanzi C, Lembo C, et al (2011) Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats. J Nutr Metab 2011:. https://doi.org/10.1155/2011/475216
Venema RC, Sayegh HS, Kent JD, Harrison DG (1996) Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial and inducible nitric oxide synthases. J Biol Chem 271:6435–6440. https://doi.org/10.1074/jbc.271.11.6435
Venkatesh V, Sharma JD, Kamal RA (2002) Comparative study of effect of alcoholic extracts of Sapindus emarginatus, Terminalia belerica, Cuminum cyminum and Allium cepa on reproductive organs of male albino rats. Asian J Exp Sci 16(1–2):51–63
Wang J, Dong S (2011) ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells. Inflammation 35:859–870. https://doi.org/10.1007/S10753-011-9387-4
Wang YK, Hong YJ, Yao YH et al (2013) 6-shogaol protects against oxidized LDL-induced endothelial injruries by inhibiting oxidized LDL-evoked LOX-1 signaling. Evid Based Complement Alternat Med. https://doi.org/10.1155/2013/503521
Wang S, Sun X, Jiang L et al (2016) 6-Gingerol induces autophagy to protect HUVECs survival from apoptosis. Chem Biol Interact 256:249–256. https://doi.org/10.1016/J.CBI.2016.07.020
Wang D, Zhang L, Huang J et al (2021) Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine. Trends Food Sci Technol 117:34–45. https://doi.org/10.1016/J.TIFS.2020.11.024
Weber C, Springer TA (1998) Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration. J Immunol 161:6825–6834. https://doi.org/10.4049/JIMMUNOL.161.12.6825
Wei Z, Lau BHS (1998) Garlic inhibits free radical generation and augments antioxidant enzyme activity in vascular endothelial cells. Nutr Res 18:61–70. https://doi.org/10.1016/S0271-5317(97)00200-5
Weksler BB, Marcus AJ, Jaffe EA (1977) Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. Proc Natl Acad Sci 74:3922–3926. https://doi.org/10.1073/PNAS.74.9.3922
Wijaya S, Soegianto L (2017) Antidiarrheal activity of the combination of ethanol extracts of turmeric rhizomes, gall oak leaves, guava leaves and meniran herbs. Jurnal Jamu Indonesia 2:96–101. https://doi.org/10.29244/JJI.V2I3.38
Yadav D, Yadav SK, Khar RK et al (2013) Turmeric (Curcuma longa L.): a promising spice for phytochemical and pharmacological activities. IJGP. https://doi.org/10.22377/IJGP.V7I2.302
Yamasaki T, Li L, Lau BHS (1994) Garlic compounds protect vascular endothelial cells from hydrogen peroxide-induced oxidant injury. Phytother Res 8:408–412. https://doi.org/10.1002/PTR.2650080706
Yang G, Gao X, Jiang L et al (2017) 6-Gingerol prevents MEHP-induced DNA damage in human umbilical vein endothelia cells. Hum Exp Toxicol 36:1177–1185. https://doi.org/10.1177/0960327116681650
Yoshikawa M, Murakami T, Komatsu H et al (1997) Medicinal foodstuffs. IV. Fenugreek seed. (1): structures of trigoneosides Ia, Ib, IIa, IIb, IIIa, and IIIb, new furostanol saponins from the seeds of Indian Trigonella foenum-graecum L. Chem Pharm Bull (tokyo) 45:81–87. https://doi.org/10.1248/CPB.45.81
Zeng H, Chen X, Liang J (2015) In vitro antifungal activity and mechanism of essential oil from fennel (Foeniculum vulgare L.) on dermatophyte species. J Med Microbiol 64:93–103. https://doi.org/10.1099/JMM.0.077768-0/CITE/REFWORKS
Zhang Y, Dou F (2019) Quercetin inhibits the formation of atherosclerosis plaque by protecting vascular endothelial cells. J Pharm Pharmacol Res 3:116–127
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Mandal, P., Kanthlal, S.K. Vascular targeting of constituents of commonly used spices and its molecular interactions in endothelial dysfunction: A review. Phytochem Rev (2024). https://doi.org/10.1007/s11101-024-09939-7
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DOI: https://doi.org/10.1007/s11101-024-09939-7