Abstract
Genus Populus (Salicaceae family) consists of dioecious, deciduous, and commercially important forest tree species which are widely spread over the Northern Hemisphere. Traditionally, Populus species are used in the treatment of rheumatism, arthritis, lower back pains, urinary complaints, digestive, liver disorders, debility, anorexia, fevers, and also relieve the pain of menstrual cramps. This review compiles or discusses the general morphology, ethno-medicinal uses and phytochemistry of Populus species along with their pharmacological activities (anti-microbial, anti-cancer, anti-inflammatory, anti-obesity, anti-diarrhea, and anti-oxidants) covering the period of 1990–2020. The literature shows that the genus Populus is a rich source of phytocompounds especially phenolic compounds, flavonoids, and terpenoids, etc. A total of one hundred and fifty-nine constituents were isolated from different plant parts like leaves, bark, buds, and roots of Populus species. Only some of the phytocompounds were screened for their biological activities and the rest of them are unexplored. Through this review, the authors hope to attract the attention of natural product researchers throughout the world to focus on the unexplored species of Populus and their unique phytocompounds. This review underlines the potential of phytocompounds from Populus species that could lead to a new pathway in Pharma industries.
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Change history
23 October 2021
A Correction to this paper has been published: https://doi.org/10.1007/s11101-021-09782-0
Abbreviations
- AlCl3 :
-
Aluminum chloride
- ABTS:
-
2,2’-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid
- NF-κB p65:
-
Blunted LPS-triggered enhanced nuclear translocation
- BDNF:
-
Brain-derived neurotrophic factor
- b.w.:
-
Body weight
- DPPH:
-
2,2-Diphenyl-1-picrylhydrazyl
- CNC:
-
Cellosaurus cell line
- DLD-1:
-
Colorectal adenocarcinoma cell
- COX-1:
-
Cyclooxygenase assay
- ESI:
-
Electrospray ionization
- FRAP:
-
Ferric reducing antioxidant power
- FTICR:
-
Fouier-transform ion cyclotron resonance mass spectrometry
- FTIR:
-
Fourier-transform infrared spectroscopy
- GC-MS:
-
Gas chromatography-mass spectrometry
- IC50 :
-
Half maximal inhibitory concentration
- HPLC:
-
High-performance liquid chromatography
- MCF-7:
-
Human breast adenocarcinoma
- BEL-7402:
-
Human hepatoma cell line
- A549:
-
Human lung adenocarcinoma
- H1299:
-
Human non-small cell lung cancer
- H2O2 :
-
Hydrogen peroxide assay
- HOCl:
-
Hypochlorous acid
- HR-MS:
-
High-resolution mass spectrometry
- IGF-1:
-
Insulin-like growth factor 1
- LC-MS:
-
Liquid chromatography-mass spectrometry
- LPS:
-
Lipopolysaccharide
- HepG2:
-
Liver hepatocellular carcinoma
- Ka-Bα:
-
Inhibitor of Kappa Bα
- µg/ml:
-
Microgram/milliliter
- µM:
-
Micromolar
- mg/ml:
-
Milligram/milliliter
- mM:
-
Millimolar
- MBC:
-
Minimum bactericidal concentration
- MFC:
-
Minimum fungicidal concentration
- MIC:
-
Minimum inhibitory concentration
- S180:
-
Murine sarcoma cancer
- NO:
-
Nitric oxide
- iNOS:
-
Nitric oxide synthesis inhibitor
- NCI-H460:
-
Non-small cell lung cancer cell line
- HUVEC:
-
Non-tumour cells
- WSl:
-
Normal skin fibroblasts
- NMR:
-
Nuclear magnetic resonance
- ORAC:
-
Oxygen radical absorbance capacity
- %:
-
Percentage
- NF-κb:
-
Phosphorylation of nuclear factor-kappa B
- PI3k/Akt/mTOR:
-
Phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin
- SOD:
-
Superoxide dismutase
- TNF-α:
-
Tumor necrosis factor alpha
- UHPLC-ESI/TOFMS:
-
Ultra-high performance liquid chromatography coupled with electrospray ionization- quadrupole-time of flight-mass spectrometry
- UA:
-
Uricemic acid
- UV:
-
Ultraviolet spectroscopy
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IG, AK and MALD conceived and designed this review; IG, AK and MALD wrote the manuscript; JD and SL collected the related references and formatting of manuscript tables; IG, MALD and N prepared chemical compounds structure; MALD, VK, AK and AKS contributed to editing the manuscript. All the authors reviewed and approved this manuscript.
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Guleria, I., Kumari, A., Lacaille-Dubois, MA. et al. A review on the genus Populus: a potential source of biologically active compounds. Phytochem Rev 21, 987–1046 (2022). https://doi.org/10.1007/s11101-021-09772-2
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DOI: https://doi.org/10.1007/s11101-021-09772-2