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Prevalence of non-adherence to antihypertensive medication in Asia: a systematic review and meta-analysis

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Abstract

Background Hypertension and its associated complications are one of the leading causes of morbidity and mortality in Asia. Racial disparities in terms of treatment outcomes among hypertension patients have been reported in literature with Asian patients resulting in poorer treatment outcomes. Non-adherence to antihypertensive therapy is frequently associated with poor treatment outcomes. Aim of the review The aim of this review was to estimate the prevalence of non-adherence to antihypertensive medications among patients with hypertension residing in Asia. Method PubMed, Google Scholar, MEDLINE, Embase, Scopus, CINHAL and Cochrane library were searched for studies published between 2000 and 2019 involving hypertensive patients. Studies investigating the prevalence of medication non-adherence in Asian countries, rated either good or fair on National Institute of Health quality assessment tool and published in English language were included in our review. Data were extracted by one author and checked by another using a structured and pilot-tested data extraction sheet. A random-effects meta-analysis was performed using STATA version 14.3®. Results Sixty-Six studies from 22 Asian countries including 2,532,582 hypertensive patients were included. Mean (± SD) age of participants was 58(± 6) years. Overall, the estimated prevalence of non-adherence to antihypertensive medication in Asia was 48% (95% CI: 41–54, P = 0.001). The rate of non-adherence was higher among females 49% (95% CI: 41–56, P = 0.001) compared to males 47% (95% CI: 40–53, P = 0.001). As per the region, the highest prevalence of non-adherence was found in South Asia 48% (95% 44–51, P = 0.877) followed by East Asia 45% (31–59, P = 0.001) and the Middle East 41 (95% 30–52, P = 0.001). Similarly, higher rate of non-adherence was observed in low and lower middle-income countries i.e. 50% (95% CI: 47–54, P = 0.220) as compare to upper-middle and high-income countries i.e. 37% (95% CI: 25–49, P = 0.001) and 44% (95% CI: 29–59, P = 0.001) respectively. Conclusion The prevalence of non-adherence to antihypertensive medication is high in Asia. This may partly explain poor treatment outcomes and incidence of higher mortality rate in Asia frequently reported in the literature. There is a need to implement appropriate policies and clinical practices to improve medication adherence.

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References

  1. Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012;380(9859):2224–60.

    Article  Google Scholar 

  2. Naseem A, Fatima A, Razzaque G, Haque N, Riaz S, Tahir M. Assessment of the level of disease state knowledge among hypertensive patients in public sector tertiary care hospitals of Quetta. Pakistan. Imp. J. Interdiscip. Res. 2017;3(3):1234–40.

    Google Scholar 

  3. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487–97.

    Article  CAS  PubMed  Google Scholar 

  4. DiMatteo MR, Giordani PJ, Lepper HS, Croghan TW. Patient adherence and medical treatment outcomes a meta-analysis. Med care. 2002;43(3):794–811.

    Article  Google Scholar 

  5. Farmer KC. Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice. Clin Ther. 1999;21(6):1074–90.

    Article  CAS  PubMed  Google Scholar 

  6. Jin C-N, Yu C-M, Sun J-P, Fang F, Wen Y-N, Liu M, et al. The healthcare burden of hypertension in Asia. Heart Asia. 2013;5(1):238–43.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Mahmood S, Jalal Z, Hadi MA, Orooj H, Shah KU. Non-adherence to prescribed Antihypertensives in primary, secondary and tertiary healthcare settings in Islamabad, Pakistan: a cross-sectional study. Patient prefere adherence. 2020;14(73):1–12.

    Google Scholar 

  8. Akeroyd JM, Chan WJ, Kamal AK, Palaniappan L, Virani SS. Adherence to cardiovascular medications in the South Asian population: a systematic review of current evidence and future directions. World J Cardiol. 2015;7(12):938–47.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Abegaz TM, Shehab A, Gebreyohannes EA, Bhagavathula AS, Elnour AA. Nonadherence to antihypertensive drugs: a systematic review and meta-analysis. Medicine. 2017;96(4):1–9.

    Article  Google Scholar 

  10. Nielsen JØ, Shrestha AD, Neupane D, Kallestrup P. Non-adherence to anti-hypertensive medication in low-and middle-income countries: a systematic review and meta-analysis of 92443 subjects. J Hum Hypertens. 2017;31(1):14.

    Article  CAS  PubMed  Google Scholar 

  11. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9.

    Article  PubMed  Google Scholar 

  12. Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007;147(8):573–7.

    Article  Google Scholar 

  13. Health NIo. Quality assessment tool for observational cohort and cross-sectional studies. National Heart, Lung, and Blood Institute Avaliable from: www nhlbi nih gov/health-pro/guidelines/indevelop/cardiovascular-risk-reduction/tools/cohort[Accessed November 5, 2015]. 2014.

  14. World-Bank. World Bank Countries Classification by Income Level. 2019. https://datahelpdesk.worldbank.org/knowledgebase/articles/906519-world-bank-country-and-lending-groups#:~:text=For%20the%20current%202021%20fiscal,those%20with%20a%20GNI%20per. Accessed 15/12/2019 2019

  15. Higgins J. Cochrane handbook for systematic reviews of interventions. Version 5.1. 0 [updated March 2011]. The Cochrane Collaboration. www cochrane-handbook org. 2011.

  16. Lee GK, Wang HH, Liu KQ, Cheung Y, Morisky DE, Wong MC. Determinants of medication adherence to antihypertensive medications among a Chinese population using Morisky medication adherence scale. PLoS ONE. 2013;8(4):96–104.

    Article  Google Scholar 

  17. Yue Z, Li C, Weilin Q, Bin W. Application of the health belief model to improve the understanding of antihypertensive medication adherence among Chinese patients. Patient Educ Couns. 2015;98(5):669–73.

    Article  PubMed  Google Scholar 

  18. Kang CD, Tsang PP, Li WT, Wang HH, Liu KQ, Griffiths SM, et al. Determinants of medication adherence and blood pressure control among hypertensive patients in Hong Kong: a cross-sectional study. Int J Cardiol. 2015;182(23):250–7.

    Article  PubMed  Google Scholar 

  19. Li YT, Wang HH, Liu KQ, Lee GK, Chan WM, Griffiths SM et al. Medication adherence and blood pressure control among hypertensive patients with coexisting long-term conditions in primary care settings: A cross-sectional analysis. Medicine (Baltimore). 2016;95(20).

  20. Athiyah U, Machfud AR, Aldila F, Yunita L, Ananda MR, Rizka NE. Measurement of Patient Adherence to the Use of Ntihypertensive Drugs by Mmas-8 nnd Pill Count in 5 Primary Health Centres of Surabaya/Antihipertansif ilaçlara hasta uyuncunun surabaya’nin 5 temel saglik merkezinde mmas-8 ve pill count yöntemleriyle belirlenmesi. FABAD JPharm Sci. 2013;38(2):91–7.

    Google Scholar 

  21. Sutar PA, Shah HK. A study of adherence pattern toward antihypertensive therapy (antihypertensive drugs, dietary habits, and physical activity) and certain factors affecting it. Int J Med Sci Public Health. 2017;6(3):463–72.

    Article  Google Scholar 

  22. Saleem F, Hassali AA, Shafie AA. Hypertension in Pakistan: time to take some serious action. Br J Gen Pract. 2010;60(575):449–50.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Han WP, Hong SA, Tiraphat S. Factors related to medication adherence among essential hypertensive patients in tertiary hospitals in Yangon, Myanmar. Indian J Public Health Res Dev. 2015;13(2):57–70.

    Google Scholar 

  24. Shaik SA, Alsuwailem A, Alhargan A, Alswailem A, Alshiha D, AlGhalib H, et al. Medications adherence level and its associated factors among hypertensive patients at a major referral hospital, in Riyadh. KSA Asian J Med Sci. 2016;7(4):24–30.

    Article  Google Scholar 

  25. Fahey M, Abdulmajeed A, Sabra K. Measurement of adherence to anti-hypertensive medication as perceived by doctors and patients. Qatar Med J. 2006;15(1):44–8.

    Google Scholar 

  26. Saadat Z, Nikdoust F, Aerab-Sheibani H, Bahremand M, Shobeiri E, Saadat H, et al. (2015) Adherence to antihypertensives in patients with comorbid condition. Nephrourol Mon. 2015;7(4):e29863.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Behnood-Rod A, Rabbanifar O, Pourzargar P, Rai A, Saadat Z, Saadat H, et al. Adherence to antihypertensive medications in Iranian patients. Int J Hypertens. 2016;2016(1):1–7.

    Article  Google Scholar 

  28. Al-Noumani H, Wu J-R, Barksdale D, Knafl G, AlKhasawneh E, Sherwood G. Health Beliefs and Medication Adherence in Omanis With Hypertension. J Cardiovasc Nurs. 2018;33(6):518–26.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Al-Ramahi R. Adherence to medications and associated factors: A cross-sectional study among Palestinian hypertensive patients. J Epidemiol Glob Health. 2015;5(2):125–32.

    Article  PubMed  Google Scholar 

  30. Yassine M, Al-Hajje A, Awada S, Rachidi S, Zein S, Bawab W, et al. Evaluation of medication adherence in Lebanese hypertensive patients. Clin Epidemiol Glob Health. 2016;6(3):157–67.

    Article  Google Scholar 

  31. Khayyat SM, Khayyat SMS, Alhazmi RSH, Mohamed MM, Hadi MA. Predictors of medication adherence and blood pressure control among Saudi hypertensive patients attending primary care clinics: a cross-sectional study. PLoS ONE. 2017;12(1):255–67.

    Article  Google Scholar 

  32. Rahmawati R, Bajorek B. Factors affecting self-reported medication adherence and hypertension knowledge: A cross-sectional study in rural villages, Yogyakarta Province. Indonesia Chronic Illn. 2018;14(3):212–27.

    Article  PubMed  Google Scholar 

  33. Violita F, Thaha ILM, Dwinata I, Susanna D. Factors Associated with Medication Adherence of Patients with Hypertension in Segeri’s HealthCenter. KnE life sci. 2018;4(4):173–80.

    Article  Google Scholar 

  34. Jhaj R, Gour PR, Kumari S, Sharma S. Association between medication adherence and blood pressure control in urban hypertensive patients in central India. Int J Non-Commun Dis. 2018;3(1):19–25.

    Article  Google Scholar 

  35. Sadeghi N. Study of adherence to treatment & its related factors in hypertensive patients referring to erman health centers in 1396: School of Medicine. Kerman, Iran: Kerman University of Medical Sciences; 2018.

    Google Scholar 

  36. Ismael Z. Compliance of Hypertensive Patients to Medication in AL-Imam AL-Hussein medical City-Karbala-2018. J Kerbala Med. 2019;11(2):36–43.

    Google Scholar 

  37. Hashmi SK, Afridi MB, Abbas K, Sajwani RA, Saleheen D, Frossard PM, et al. Factors associated with adherence to anti-hypertensive treatment in Pakistan. PLoS ONE. 2007;2(3):1–8.

    Article  Google Scholar 

  38. Ma C. A cross-sectional survey of medication adherence and associated factors for rural patients with hypertension. Appl Nurs Res. 2016;31(6):94–9.

    Article  PubMed  Google Scholar 

  39. Yang S, He C, Zhang X, Sun K, Wu S, Sun X, et al. Determinants of antihypertensive adherence among patients in Beijing: application of the health belief model. Patient Educ Couns. 2016;99(11):1894–900.

    Article  PubMed  Google Scholar 

  40. Bhandari B, Bhattarai M, Bhandari M, Ghimire A, Pokharel P. Morisky D (2015) Adherence to antihypertensive medications: population based follow up in Eastern Nepal. J Nepal Health Res Counc. 2015;13(29):38–42.

    CAS  PubMed  Google Scholar 

  41. Elbur AI. Level of adherence to lifestyle changes and medications among male hypertensive patients in two hospitals in Taif; Kingdom of Saudi Arabia. Int J Pharm Pharm Sci. 2015;7(4):168–72.

    Google Scholar 

  42. Bader R, Koprulu F, Hassan N, Ali A, Elnour A. Predictors of adherence to antihypertensive medication in northern United Arab Emirates. East Mediterr health j. 2015;21(5):309–18.

    Article  CAS  PubMed  Google Scholar 

  43. Kamran A, Ahari SS, Biria M, Malpour A, Heydari H. Determinants of patient’s adherence to hypertension medications: application of health belief model among rural patients. Ann Med Health Sci Res. 2014;4(6):922–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Kamel BA-JAA, Barhoom H. Knowledge about Hypertension and Antihypertensive medication compliance in a Jordanian community sample. J Interprof Educ Pract. 2013;4(24):81–7.

    Google Scholar 

  45. Balasubramanian A, Nair SS, Rakesh P, Leelamoni K. Adherence to treatment among hypertensives of rural Kerala. India J Family Med Prim Care. 2018;7(1):64–9.

    Article  PubMed  Google Scholar 

  46. Arshad AR. Frequency of poor adherence to antihypertensive treatment and an analysis of clinico-demographic correlates. J Coll Physicians Surg Pak. 2015;25(12):911–13.

    PubMed  Google Scholar 

  47. Lo SH, Chau JP, Woo J, Thompson DR, Choi KC. Adherence to antihypertensive medication in older adults with hypertension. J Cardiovasc Nurs. 2016;31(4):296–303.

    Article  PubMed  PubMed Central  Google Scholar 

  48. David R, Singh S, Isaac R. A study of treatment adherence and control status of diagnosed hypertensive patients in a rural community. Ludhiana. Int J Res Med Sci. 2015;3(2):247–51.

    Google Scholar 

  49. Ramli A, Ahmad NS, Paraidathathu T. Medication adherence among hypertensive patients of primary health clinics in Malaysia. Patient prefere adherence. 2012;6(3):613.

    Google Scholar 

  50. Schuiling-Veninga CC, Nguyen TBY, Vu T-H, Wright EP, Postma MJ. Adherence to hypertension medication: quantitative and qualitative investigations in a rural Northern Vietnamese community. PLoS ONE. 2017;12(2):1–13.

    Google Scholar 

  51. Saito I, Nomura M, Hirose H, Kawabe H. Use of home blood pressure monitoring and exercise, diet and medication compliance in Japan. Clin Exp Hypertens. 2010;32(4):210–3.

    Article  PubMed  Google Scholar 

  52. Bhandari S, Sarma PS, Thankappan KR. Adherence to antihypertensive treatment and its determinants among urban slum dwellers in Kolkata. India Asia-Pac J Public Health. 2015;27(2):NP74–84.

    Article  PubMed  Google Scholar 

  53. Hossain SZ, Islam MR, Biswas S, Biswas PK, Hossain MZ, Islam N, et al. Pattern of compliance to anti-hypertensive medications in hypertensive patients in a tertiary care hospital in Bangladesh. J Dhaka Med Coll. 2015;24(1):62–6.

    Article  Google Scholar 

  54. Karmoker KK, Dutta B, Khalil MI, Rashid MB, Alam MA, Islam MJ, et al. Treatment compliance of Hypertensive patients. J Cardiovasc. 2016;8(2):110–4.

    Article  Google Scholar 

  55. Khanam MA, Lindeboom W, Koehlmoos TLP, Alam DS, Niessen L, Milton AH. Hypertension: adherence to treatment in rural Bangladesh–findings from a population-based study. Glob Health Action. 2014;7(1):25028.

    Article  PubMed  Google Scholar 

  56. Hussanin S, Boonshuyar C, Ekram A. Non-adherence to antihypertensive treatment in essential hypertensive patients in Rajshahi, Bangladesh. Anwer Khan Mod Med Coll J. 2011;2(1):9–14.

    Article  Google Scholar 

  57. Ekram AS, Hussain SM, Boonshuyar C. Preliminary report on non-adherence to antihypertensive treatment in essential hypertensive patients: a community based survey. J Teach Assoc. 2008;21(2):112–7.

    Article  Google Scholar 

  58. Ahmed N, Abdul Khaliq M, Shah SH, Anwar W. Compliance to antihypertensive drugs, salt restriction, exercise and control of systemic hypertension in hypertensive patients at Abbottabad. J Ayub Med Coll Abbottabad. 2008;20(2):66–9.

    PubMed  Google Scholar 

  59. Al Sowielem L, El Zubier A. Compliance and knowledge of hypertensive patients attending PHC centres in Al-Khobar. Saudi Arabia East Mediterr health j. 1998;4(2):301–7.

    Article  Google Scholar 

  60. Goussous LS, Halasah NA, Halasa M. Non-Compliance to Antihypertensive treatment among patients attending prince Zaid military hospital. Fam Med. 2015;13(1):15–9.

    Google Scholar 

  61. Al-banna HI, Moha SMS. Compliance to Antihypertensive treatment and causes of partial or poor compliance in patients attending Ali-Kamal consultation center in Suliamania. Zanco J Med Sci. 2010;14(1):78–84.

    Google Scholar 

  62. Cingil D, Delen S, Aksuoğlu A. Evaluation of compliance and level of knowledge of patients with hypertension living in Karaman city center. Turkey Turk Kardiyol Dern Ars. 2009;37(8):551–6.

    PubMed  Google Scholar 

  63. Zhang Y, Li X, Mao L, Zhang M, Li K, Zheng Y, et al. Factors affecting medication adherence in community-managed patients with hypertension based on the principal component analysis: evidence from Xinjiang. China Patient prefer adherence. 2018;12(1):803–15.

    Article  PubMed  Google Scholar 

  64. Suzuki T, Shiga T, Omori H, Tatsumi F, Nishimura K, Hagiwara N. Self-reported non-adherence to medication in Japanese patients with cardiovascular diseases. J Cardiovasc Pharmacol. 2018;18(4):311–6.

    CAS  Google Scholar 

  65. Shah AJ, Singh V, Patil SP, Gadkari MR, Ramchandani V, Doshi KJ. Factors affecting compliance to antihypertensive treatment among adults in a tertiary care hospital in Mumbai. Indian J Community Med. 2018;43(1):53–5.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Gupta SK. Treatment adherence among people living with hypertension in periurban community of Chandigarh: a cross sectional Study. Paripex Indian J Res. 2019;8(9):88–9.

    Google Scholar 

  67. Shrestha B, Ferdoush Z, Rabbi F, Hossain A. Adherence to medications among Nepali hypertensive population: a hospital-based cross-sectional study. Biomed Res Int. 2018;3(1):1–4.

    Google Scholar 

  68. Alkhamis AM, Alsalman AJ, Al Khamis M, Alkhamis A, Alotaibi NM. Prevalence of Nonadherence to Antihypertensive Medications among Adults Attending Primary Healthcare Clinics in Al-Hasa Region: A Cross-Sectional Study. Dr Sulaiman Al Habib Medical Journal. 2019;1(2):26–43.

    Google Scholar 

  69. Alotayfi MJY, Alsohaimi SA, ALQadiKamilAththi Alhazmi BKSMAJHGAA, et al. Poor compliance to AntiHypertensive drugs in Saudi Arabia. Egypt J Hosp Med. 2018;73(5):6696–701.

    Article  Google Scholar 

  70. Abdelhalim HN, Zahrani AI, Shuaibi AM. Factors affecting treatment compliance of patients on antihypertensive therapy at National Guard Health Affairs (NGHA) Dammam Primary Health Care Clinics (PHCC). J Family Comm Med. 2019;26(3):168–72.

    Google Scholar 

  71. Alqarni AM, Hammad AS, Alhejaili MA, Alatawi AA, Alrashedi MH, Alenezi MF, et al. Assessment of adherence to hypertension medications and awareness of hypertension medications among people with hypertension in Tabuk. Egypt J Hosp Med. 2018;70(8):1365–70.

    Article  Google Scholar 

  72. Matsumura S, Watanabe K, Fukuhara S. The association between physician’s affiliation and patients’ adherence to their antihypertensive medication and pharmaceutical knowledge. J Gen Fam Med. 2019;20(1):19–24.

    Article  PubMed  Google Scholar 

  73. Choi HY, Im Jung OhJAL, Lim J, Kim YS, Jeon T-H, Cheong Y-S, et al. Korean J Fam Med. Korean J family med. 2018;39(6):325–32.

    Article  Google Scholar 

  74. Woodham N, Taneepanichskul S, Somrongthong R, Auamkul N. Medication adherence and associated factors among elderly hypertension patients with uncontrolled blood pressure in rural area. Northeast Thailand J Health Res. 2018;32(6):449–58.

    Google Scholar 

  75. Al-daken LI, Eshah NF. Self-reported adherence to therapeutic regimens among patients with hypertension. Clin Exp Hypertens. 2017;39(3):264–70.

    Article  CAS  PubMed  Google Scholar 

  76. Ullah M, Saha SK, Rahman MT, Karim MA, Ahmed R. Nonadherence to drugs among the hypertensive patients in outpatient department of a secondary hospital of Bangladesh. JCardiovasc. 2019;11(2):105–13.

    Article  Google Scholar 

  77. Dennis T, Meera N, Binny K, Sekhar MS, Kishore G, Sasidharan S. Medication adherence and associated barriers in hypertension management in India. CVD Prev Cont. 2011;6(1):9–13.

    Google Scholar 

  78. Pan J, Wu L, Wang H, Lei T, Hu B, Xue X, et al. Determinants of hypertension treatment adherence among a Chinese population using the therapeutic adherence scale for hypertensive patients. Medicine (Baltimore). 2019;98(27):1–13.

    Article  Google Scholar 

  79. Park J-H, Shin Y, Lee S-Y, Lee SI. Antihypertensive drug medication adherence and its affecting factors in South Korea. Int J Cardiol. 2008;128(3):392–8.

    Article  PubMed  Google Scholar 

  80. Ishida T, Oh A, Hiroi S, Shimasaki Y, Nishigaki N, Tsuchihashi T. Treatment patterns and adherence to antihypertensive combination therapies in Japan using a claims database. Hypertens Res. 2019;42(2):249.

    Article  CAS  PubMed  Google Scholar 

  81. Pinprapapan E, Panuthai S, Vannarit T, Srisuphan W. Casual model of adherence to therapeutic regimens among Thais with hypertension. Pac Rim Int J Nurs Res. 2013;17(3):268–81.

    Google Scholar 

  82. Goussous LS, Halasah NA, Halasa M. Non-Compliance to Antihypertensive Treatment among Patients Attending Prince Zaid Military Hospital. World Family Medicine J: Incorporat Middle East J Family Med. 2015;99(1645):1–5.

    Google Scholar 

  83. Organization WH. A global brief on hypertension: silent killer, global public health crisis: World Health Day 2013: World Health Organization2013.

  84. Boucquemont J, Pai AL, Dharnidharka VR, Hebert D, Furth SL, Foster BJ. Gender differences in medication adherence among adolescent and young adult kidney transplant recipients. Transplantation. 2019;103(4):798–806.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Kumar K, Greenfield S, Raza K, Gill P, Stack R. Understanding adherence-related beliefs about medicine amongst patients of South Asian origin with diabetes and cardiovascular disease patients: a qualitative synthesis. BMC Endocr Disord. 2016;16(1):24–9.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Ens TA, Seneviratne CC, Jones C, Green TL, King-Shier KM. South Asians’ cardiac medication adherence. Eur J Cardiovasc. 2014;13(4):357–68.

    Article  Google Scholar 

  87. Hsu Y-H, Mao C-L, Wey M. Antihypertensive medication adherence among elderly Chinese Americans. J Transcult Nurs. 2010;21(4):297–305.

    Article  PubMed  Google Scholar 

  88. Garavalia L, Garavalia B, Spertus JA, Decker C. J Cardiovasc Nurs. J Cardiovasc Nurs. 2009;24(5):371–9.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Sabate E (2016) Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003. Google Scholar.

  90. Choudhry NK, Denberg TD, Qaseem A. Improving adherence to therapy and clinical outcomes while containing costs: opportunities from the greater use of generic medications: best practice advice from the clinical guidelines committee of the American college of physicians. Ann Intern Med. 2016;164(1):41–9.

    Article  PubMed  Google Scholar 

  91. Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med. 2007;167(6):540–9.

    Article  PubMed  Google Scholar 

  92. Gazmararian JA, Williams MV, Peel J, Baker DW. Health literacy and knowledge of chronic disease. Patient Educ Couns. 2003;51(3):267–75.

    Article  PubMed  Google Scholar 

  93. Gwadry-Sridhar FH, Manias E, Lal L, Salas M, Hughes DA, Ratzki-Leewing A, et al. Impact of interventions on medication adherence and blood pressure control in patients with essential hypertension: a systematic review by the ISPOR medication adherence and persistence special interest group. Value Health. 2013;16(5):863–71.

    Article  PubMed  Google Scholar 

  94. Conn VS, Ruppar TM, Chase J-AD, Enriquez M, Cooper PS. Interventions to improve medication adherence in hypertensive patients: systematic review and meta-analysis. Curr Hypertens Rep. 2015;17(12):94–109.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Palacio AM, Uribe C, Hazel-Fernandez L, Li H, Tamariz LJ, Garay SD, et al. Can phone-based motivational interviewing improve medication adherence to antiplatelet medications after a coronary stent among racial minorities? A randomized trial. J Gen Intern Med. 2015;30(4):469–75.

    Article  PubMed  Google Scholar 

  96. Zomahoun HTV, Guenette L, Gregoire J-P, Lauzier S, Lawani AM, Ferdynus C, et al. Effectiveness of motivational interviewing interventions on medication adherence in adults with chronic diseases: a systematic review and meta-analysis. Int J Epidemiol. 2017;46(2):589–602.

    PubMed  Google Scholar 

  97. Fenerty SD, West C, Davis SA, Kaplan SG, Feldman SR. The effect of reminder systems on patients’ adherence to treatment. Patient Prefer Adherence. 2012;2012(6):127–35.

    Google Scholar 

  98. Jin J, Sklar GE, Oh VMS, Li SC. Factors affecting therapeutic compliance: A review from the patient’s perspective. Ther Clin Risk Manag. 2008;4(1):269–86.

    PubMed  PubMed Central  Google Scholar 

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  1. Department of Pharmacy, Quaid-E-Azam University, Islamabad, 45320, Pakistan

    Sajid Mahmood & Kifayat Ullah Shah

  2. School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

    Zahraa Jalal & Muhammad Abdul Hadi

  3. Institute of Applied Health Research, University of Birmingham, Birmingham, B15 2TT, UK

    M. Sayeed Haque

  4. Institute of Pharmaceutical Sciences, University of Veterinary and Animal Science (UVAS), Lahore, Pakistan

    Tahir Mehmood Khan

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Mahmood, S., Jalal, Z., Hadi, M.A. et al. Prevalence of non-adherence to antihypertensive medication in Asia: a systematic review and meta-analysis. Int J Clin Pharm 43, 486–501 (2021). https://doi.org/10.1007/s11096-021-01236-z

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