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Factors affecting the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus in preterm infants

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Abstract

Background Data on the effectiveness of oral ibuprofen treatment for patent ductus arteriosus are limited, and the factors affecting its effectiveness remain unclear. Objective The aim was to identify the potential factors affecting the clinical effectiveness of oral ibuprofen in preterm infants. Setting Neonatal intensive care unit in a prefecture-level maternal and child healthcare hospital in China. Method Over a 5-years period, the medical records of 327 preterm infants with patent ductus arteriosus who were admitted to the neonatal intensive care unit of our hospital to receive a single course of oral ibuprofen were retrospectively reviewed. Main outcome measures The prevalence of risk factors affecting the effectiveness of oral ibuprofen. Results In total, 201 (61.47%) preterm infants were considered to have undergone “effective therapy” and classified accordingly, whereas 11 (3.36%) showed certain adverse events. Factors affecting therapeutic effectiveness were postnatal age at the initiation of treatment and Day 1/Day 0 ratio of urine output/fluid intake during the treatment course, with odds ratios of 0.892 (95% CI: 0.835–0.953; P = 0.001) and 0.473 (95% CI 0.265–0.845; P = 0.011), respectively. Conclusion A single course of oral ibuprofen for patent ductus arteriosus closure among preterm infants is effective and safe. Preterm infants with postnatal age of ≤ 9 days at the initiation of treatment and Day 1/Day 0 ratio of ≤ 0.708 of the urine output/fluid intake during the treatment course can be considered predictors of effectiveness of patent ductus arteriosus.

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Acknowledgements

The authors would like to acknowledge the pediatricians and nurses at our NICU for supporting this study.

Funding

This study was funded by the Natural Science Foundation of Ningbo (2018A610245 to C.Y.), Zhejiang Province Public Welfare Technology Application Research Project (2017C35010 to Q.L.), and Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (2020KY279 to Q.L.).

Conflicts of interest

The authors declare that they have no conflict of interest.

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Author notes

  1. Chaohui Ye and Qin Lyu have contributed equally to the work.

Authors and Affiliations

  1. Department of Pharmacy, Ningbo Women and Children’s Hospital, Ningbo, 315012, Zhejiang, China

    Chaohui Ye, Jie Zhang & Xiaodong Lu

  2. Department of Neonatal Intensive Care Unit, Ningbo Women and Children’s Hospital, Ningbo, 315012, Zhejiang, China

    Qin Lyu, Linyan Jiang & Yinquan Xu

  3. Department of Pharmacy, Ningbo Psychiatric Hospital, Ningbo, 315000, Zhejiang, China

    Li Yu

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  1. Chaohui Ye
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Correspondence to Qin Lyu.

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Ye, C., Lyu, Q., Jiang, L. et al. Factors affecting the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus in preterm infants. Int J Clin Pharm 43, 1074–1081 (2021). https://doi.org/10.1007/s11096-020-01219-6

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  • DOI: https://doi.org/10.1007/s11096-020-01219-6

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