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Amphiphilic Ionic Liquids Capable to Formulate Organized Systems in an Aqueous Solution, Designed by a Combination of Traditional Surfactants and Commercial Drugs

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Abstract

The present review describes the state of the art in the conversion of pharmaceutically active ingredients (API) in amphiphilic Ionic Liquids (ILs) as alternative drug delivery systems. In particular, we focus our attention on the compounds generated by ionic exchange and without original counterions which generate different systems in comparison with the simple mixtures. In water, these new amphiphiles show similar or even better properties as surfactants in comparison with their precursors. Cations such as 1-alkyl-3-methyl-imidazolium and anions such as dioctyl sulfosuccinate or sodium dodecyl sulfate appear as the amphiphilic components most studied. In conclusion, this work shows interesting information on several promissory compounds and they appear as an interesting challenge to extend the application of ILs in the medical field.

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Acknowledgments

R.D.F., N.M.C. and J.J.S. hold a research position at Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). N. D. thanks Agencia Nacional de Promoción Científica y Técnica for a research fellowship.

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Authors and Affiliations

  1. Departamento de Química, Universidad Nacional de Rio Cuarto, Agencia Postal 3, C.P. X5804BYA, Ruta Nacional 36, km 601, Rio Cuarto, Córdoba, Argentina

    Nahir Dib, Juana J. Silber, N. Mariano Correa & R. Dario Falcone

  2. Instituto de Desarrollo Agroindustrial y de la Salud (IDAS), Universidad Nacional de Río Cuarto, Agencia Postal 3, C.P. X5804BYA, Ruta Nacional 36, km 601, Río Cuarto, Córdoba, Argentina

    Nahir Dib, Juana J. Silber, N. Mariano Correa & R. Dario Falcone

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  1. Nahir Dib
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Contributions

Nahir Dib: Conceptualization, Writing - review & editing, Visualization. N. Mariano Correa: Writing - review & editing, Visualization, Supervision. Juana J. Silber: Writing - review & editing, Visualization, Supervision. R. Dario Falcone: Writing-original draft, Conceptualization, Writing - review & editing, Visualization, Supervision. All authors have read and agreed to the published version of the manuscript.

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Correspondence to R. Dario Falcone.

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Dib, N., Silber, J.J., Correa, N.M. et al. Amphiphilic Ionic Liquids Capable to Formulate Organized Systems in an Aqueous Solution, Designed by a Combination of Traditional Surfactants and Commercial Drugs. Pharm Res 39, 2379–2390 (2022). https://doi.org/10.1007/s11095-022-03342-7

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