Results from studies of the antidiabetic and antihyperglycemic activity of a low-molecular-weight NGF mimetic, compound GR-2 [bis-(N-monosuccinyl-L-glutamyl-L-lysine)hexamethylenediamide], on a streptozotocin-induced diabetes model in Wistar rats are presented. GK-2 administered perorally at a dose of 5 mg/kg for 28 d significantly reduced the glycemia level in diabetic rats and increased the overall plasma antioxidant capacity. The glycemia level and plasma antioxidant capacity were in an inverse exponential relationship and were closely correlated to each other (correlation coefficient 0.899).
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References
L. J. Marnett, Toxicology, 181 – 182, 219 – 222 (2002).
A. P. Rolo and C. M. Palmeira, Toxicol. Appl. Pharmacol., 212(2), 167 – 178 (2006).
S. Golbidi, M. Badran, and L. Laher, Exp. Diabetes Res., 2012, 1 – 16 (2012).
J. Pi, Q. Zhang, J. Fu, et al., Toxicol. Appl. Pharmacol., 244(1), 77 – 83 (2010).
J. Houtz, Ph. Borden, A. Ceasrine, et al., Dev. Cell, 39(3), 329 – 345 (2016).
S. Gezginci-Oktayoglu, A. Karatug, and S. Bolkent, Diabetes / Metab. Res. Rev., 28(8), 654 – 662 (2012).
B. S. Diniz, A. L. Teixeira, R. Machado-Viera, et al., Am. J. Geriatr. Psychiatry, 21(5), 493 – 496 (2013).
T. K. Ali, M. M. Al-Gayyar, S. Matragoon, et al., Diabetologia, 54, 657 – 668 (2011).
T. A. Gudasheva, T. A. Antipova, and S. B. Seredenin, Dokl. Akad. Nauk, 434(4), 549 – 552 (2010).
T. A. Gudasheva, P. Y. Povarnina, A. V. Tarasiuk, and S. B. Seredenin, Med. Res. Rev., 41(5), 2746 – 2774 (2021).
S. B. Seredenin and T. A. Gudasheva, RU Pat. No. 2,410,392, Aug. 27, 2010.
T. A. Gudasheva, P. Y. Povarnina, T. A. Antipova, et al., J. Biomed. Sci., 22(5), 106 (2015).
R. U. Ostrovskaya and S. V. Ivanov, Endocr., Metab. Immune Disord.: Drug Targets, 22(8), 834 – 841 (2022).
R. U. Ostrovskaya, S. V. Ivanov, T. A. Gudasheva, et al., Acta Nat., 11(1), 48 – 57 (2019).
S. V. Ivanov, R. U. Ostrovskaya, M. S. Demorzhi, et al., Khim.-farm. Zh., 57(8), 3 – 8 (2023).
S. V. Ivanov, R. U. Ostrovskaya, K. N. Kolyasnikova, et al., Clin. Exp. Pharmacol. Physiol., 49(10), 1116 – 1125 (2022).
S. S. Yagubova, N. N. Zolotov, R. U. Ostrovskaya, and T. A. Gudasheva, Bull. Exp. Biol. Med., 174(2), 273 – 276 (2022).
S. P. Zavadskii, I. I. Krasnyuk, Jr., Yu. Ya. Kharitonov, et al., Razrab. Regist. Lek. Sredstv, 2, 214 – 221 (2017).
I. R. Ilyasov, V. L. Beloborodov, I. A. Selivanova, and R. P. Terekhov, Int. J. Mol. Sci., 21, 1131 (2020).
A. Cano and M. B. Arnao, in: Measurement of Antioxidant Activity & Capacity, John Wiley & Sons Ltd., Chichester (2017), pp. 117 – 139.
N. M. Sazonova, A. V. Tarasyuk, D. V. Kurilov, et al., Khim.-farm. Zh., 49(7), 10 – 19 (2015).
R. Re, N. Pellegrini, A. Proteggente, et al., Free Radical Biol. Med., 26(9 – 10), 1231 – 1237 (1999).
I. R. Ilyasov, V. L. Beloborodov, and I. A. Selivanova, Chem. Pap., 72, 1917 – 1925 (2018).
A. Taldaev, A. D. Savina, V. V. Olicheva, et al., Int. J. Mol. Sci., 24(15), 11962 (2023).
I. R. Ilyasov, V. L. Beloborodov, D. I. Antonov, et al., Antioxidants, 9, 695 (2020).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 12, pp. 13 – 16, December, 2023.
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Ivanov, S.V., Ostrovskaya, R.U., Olicheva, V.V. et al. Low Molecular Weight NGF Mimetic Enhances the Overall Plasma Antioxidant Capacity in Rats with Streptozotocin-Induced Diabetes. Pharm Chem J 57, 1858–1861 (2024). https://doi.org/10.1007/s11094-024-03089-y
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DOI: https://doi.org/10.1007/s11094-024-03089-y