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Synthesis and Antiulcer Activity of Aromatic and Heterocyclic Amides of 3-O-Acetylglycyrrhetic Acid

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C30-amides of 3-O-acetylglycyrrhetic acid containing aromatic and heterocyclic pharmacophores were synthesized by the acid chloride method. The antiulcer activity of 3-O-acetylglycyrrhetic acid amides with piperazine (IV), aniline (VI), and 2-aminothiazole-3-phenyl (X) was studied in the indomethacin ulcer model of the gastric mucosa of rats at a dose of 50 mg/kg. Amides IV and X had the highest antiulcer activity comparable to that of the reference drug Omez.

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Acknowledgments

We thank the Khimiya CCU for performing the spectral studies.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054, Russia

    E. R. Karimova, N. S. Makara, T. A. Sapozhnikova & L. A. Baltina

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  1. E. R. Karimova
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  2. N. S. Makara
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  3. T. A. Sapozhnikova
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  4. L. A. Baltina
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Correspondence to L. A. Baltina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 11, pp. 29 – 37, November, 2023.

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Karimova, E.R., Makara, N.S., Sapozhnikova, T.A. et al. Synthesis and Antiulcer Activity of Aromatic and Heterocyclic Amides of 3-O-Acetylglycyrrhetic Acid. Pharm Chem J 57, 1717–1725 (2024). https://doi.org/10.1007/s11094-024-03071-8

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  • DOI: https://doi.org/10.1007/s11094-024-03071-8

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