Current data on the use of antimicrobial preservatives in soft dosage forms are presented. Information analysis and analytical studies of regulatory documentation regarding the inclusion of preservatives in the studied group of drugs were carried out. The current range of antimicrobial preservatives included in soft dosage forms is presented. The effectiveness of parabens was evaluated using gel and ointment for topical application as examples.
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Acknowledgments
We thank colleagues and staff of the Microbiology Laboratory,
SCEEMP, Ministry of Health of Russia, for assistance
in performing the experimental studies.
Contributions of authors
LVTs selected and analyzed the preservatives of the studied drugs, was responsible for the accuracy of the results, and wrote the manuscript text; OVG formulated the study plan and reviewed the literature, performed the study determining the effectiveness of the antimicrobial design, edited the manuscript text, and critically reviewed the manuscript.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 10, pp. 52 – 56, October, 2023
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Tsyganova, L.V., Gunar, O.V. On Antimicrobial Preservatives in Soft Dosage Forms. Pharm Chem J 57, 1661–1665 (2024). https://doi.org/10.1007/s11094-024-03062-9
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DOI: https://doi.org/10.1007/s11094-024-03062-9