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Crystal Structure, Anticancer, and Antimicrobial Evaluation of a Novel Substituted Pyrazole Ligand and Its Co(II), Ni(II), and Zn(II) Complexes

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Pharmaceutical Chemistry Journal Aims and scope

Synthesis of substituted heterocyclic organic ligands and their metal complexes attract more attention in coordination chemistry in recent years owing to its interesting applications in pharmaceutical fields. In this research investigation, we designed a novel thio-substituted pyrazole ligand and synthesized its three novel Co(II), Ni(II), and Zn(II) metal complexes. The ligand, thio-substituted pyrazole is characterized by using single crystal x-ray diffraction data and various physico-chemical measurements such as elemental analysis and UV-Vis, IR, 13C, and 1H NMR, and HRMS spectral techniques. X-ray single crystal measurement of the substituted pyrazole was made on a Brucker AXS Kappa APEX II CCD diffractometer with graphite monochromatic MoK radiation. Metal complexes were characterized by various physico-chemical measurements such as elemental analysis, molar conductance, magnetic susceptibility data, and various spectral data supports. Based on the data obtained from those measurements, an octahedral geometry was assigned to all metal complexes. Furthermore, biological applications of the synthesized complexes were evaluated, mainly their cytotoxic, antitumour, and antimicrobial activities. Zn(II) complex has shown eminent cytotoxic ability, with an IC50 value of 46 μg/mL and its anticancer skill is scrutinized against “Ehrlich’s Ascites Carcinoma” cell line-induced ascites tumour and “Dalton’s Lymphoma Ascites” cell line-induced solid tumour in mice. Additionally, all the metal complexes showed promising antimicrobial skill against selected Gram-positive and Gram-negative bacteria.

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Acknowledgements

Authors expresses their gratitude to Amala Cancer Research Centre and STIC Cusat, Cochin for conducting elemental analysis and spectral analysis.

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The authors declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Department of Chemistry, Govt. Arts and Science College Kozhikode, Meenchanda, Kerala, 673018, India

    K. Subin Kumar

  2. Department of Physics, Govt. College Madappally, Vadakara, Kozhikode, 6731002, Kerala, India

    V. N. Reena

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Correspondence to K. Subin Kumar.

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Kumar, K.S., Reena, V.N. Crystal Structure, Anticancer, and Antimicrobial Evaluation of a Novel Substituted Pyrazole Ligand and Its Co(II), Ni(II), and Zn(II) Complexes. Pharm Chem J 57, 1251–1259 (2023). https://doi.org/10.1007/s11094-024-03031-2

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  • DOI: https://doi.org/10.1007/s11094-024-03031-2

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