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Design, Preparation and Studies Regarding Cytotoxic Properties of Benzyl Oleanates

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Pharmaceutical Chemistry Journal Aims and scope

Oleanolic acid (OA) is a natural product with certain antitumor activity. In order to enhance its cytotoxicity, a total of five derivatives of OA were designed and synthesized. Their cytotoxicity against MDA-MB-231cells (human breast cancer cells), A549 cells (human nonsmall cell lung cancer cells) and BEAS-2B cells (human cervical cancer cells) were evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results indicated that these target compounds have a wide molar activity range and some of them showed better activity than the commercial drug, doxorubicin. Compound 2a induces apoptosis of 14, 27, and 56% of MDA-MB-231 cells at 2, 4, and 8 mM respectively, and shows a linear correlation of concentration.

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Author notes

  1. Qing-Xuan Zheng and Rui Wang these authors contributed equally to this work.

Authors and Affiliations

  1. Marine College, Shandong University, Weihai, 264209, P. R. China

    Qing-Xuan Zheng & Qi-Yong Huai

  2. Sustainable Chemistry for Metals and Molecules, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium

    Rui Wang & Wim Dehaen

  3. School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai, 264209, P. R. China

    Hui-Jing Li

Authors
  1. Qing-Xuan Zheng
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  2. Rui Wang
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  3. Hui-Jing Li
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  5. Qi-Yong Huai
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Correspondence to Qi-Yong Huai.

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Zheng, QX., Wang, R., Li, HJ. et al. Design, Preparation and Studies Regarding Cytotoxic Properties of Benzyl Oleanates. Pharm Chem J 57, 1174–1178 (2023). https://doi.org/10.1007/s11094-024-03023-2

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  • DOI: https://doi.org/10.1007/s11094-024-03023-2

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