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Study of the Adhesive Characteristics of Mucoadhesive Polymer Systems by Rotational Viscometry

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

None of the methods currently proposed for studying various adhesion characteristics of polymers and approved for use in dosage form formulations is standardized and recommended by regulations. The aim of the present work was to develop and test a modified method for determining mucoadhesion on a coaxial rotational viscometer using a pool of samples with known mucoadhesive properties (xanthan gum, cross-linked acrylic polymers, and various cellulose derivatives in similar concentrations). The prospects of using a rheological method for estimating the mucoadhesion of polymer solutions were demonstrated. A general visual assessment of the rheograms, i.e., the shape, smoothness, peaks, plateau zone, and shear-stress range, could be used for screening even in the absence of generally accepted optimal shear-stress values.

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Acknowledgments

We are especially thankful to staff members of the Scientific and Technological Center for Extreme and Emergency Medicine of Moscow Institute of Physics and Technology for assistance with these investigations.

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Authors and Affiliations

  1. Nelyubin Institute of Pharmacy, Sechenov University, Ministry of Health of the Russian Federation, 96/1 Prosp. Vernadskogo, Moscow, 119571, Russia

    E. O. Bakhrushina, V. M. Kondratyeva, A. I. Khodenok, N. B. Demina & I. I. Krasnyuk

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  1. E. O. Bakhrushina
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  2. V. M. Kondratyeva
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  3. A. I. Khodenok
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  4. N. B. Demina
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  5. I. I. Krasnyuk
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Corresponding author

Correspondence to N. B. Demina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 3, pp. 35 – 44, March, 2023.

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Bakhrushina, E.O., Kondratyeva, V.M., Khodenok, A.I. et al. Study of the Adhesive Characteristics of Mucoadhesive Polymer Systems by Rotational Viscometry. Pharm Chem J 57, 414–423 (2023). https://doi.org/10.1007/s11094-023-02899-w

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  • DOI: https://doi.org/10.1007/s11094-023-02899-w

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