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Histopathological and Enzymological Evaluation of Opium Tincture and Protective Effects of Chicory Extract on Liver Structure in Adult Male Rats

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Pharmaceutical Chemistry Journal Aims and scope

Opium tincture (OT) is one of the common drugs in the treatment of addiction. However, the metabolism of its chemical compounds (e.g. morphine) may be side effects on liver. The present study aimed to the effect of OT on liver tissue in animal model and also, evaluated outcome of dose-depended of chicory extract on hepatotoxicity. In the present study, 70Wistar rats were divided into 10 groups: 1. Control, 2. Vehicle, 3. Therapeutics groups (T1: 0.2 mL of OT, T2: 0.15 mL of OT, T3: 0.1 mL of OT, TC1: 0.15 mL of OT and 100 mg/kg of chicory, TC2: 0.15 mL of OT and 250 mg/kg of chicory, TC3: 0.15 mL of OT and 400 mg/kg chicory, CT1: 0.2 mL of OT and 250 mg/kg of chicory, CT2: 0.1 mL of OT and 250 mg/kg of chicory). The enzymes level of liver were measured. Also, the histopathological analysis were performed. The evaluation of liver enzymes level showed a significant difference between T1 and vehicle groups (P < 0.05). However, there was no significant difference between groups received to chicory compared with vehicle group. Also, the mean of hepatocytes diameter and number of Kupffer cells significantly increase in T1 and T2 groups compared with vehicle group (P < 0.05). Administration of high concentration of OT may cause hepatotoxicity and it seems that 0.1 mL concentration of OT (2 mg of morphine) may be suitable in addiction withdrawal. Also, the chicory extract in a dose-dependent manner is useful in reduction of hepatotoxicity.

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran

    Reihaneh Seyedebrahimi & Mohsen Eslami Farsani

  2. Department of Medical Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran

    Maryam Azimzadeh

  3. Molecular and Medicine Research Center, Khomein University of Medical Sciences, Khomein, Iran

    Shima Ababzadeh

  4. Tissue Engineering Department, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran

    Shima Ababzadeh

  5. Department of Biology, Faculty of Basic Science, Islamic Azad University, Qom branch, Qom, Iran

    Nasrin Heidarieh & Masomeh Bahrami

Authors
  1. Reihaneh Seyedebrahimi
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  2. Maryam Azimzadeh
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  3. Shima Ababzadeh
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  4. Nasrin Heidarieh
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Correspondence to Mohsen Eslami Farsani.

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Seyedebrahimi, R., Azimzadeh, M., Ababzadeh, S. et al. Histopathological and Enzymological Evaluation of Opium Tincture and Protective Effects of Chicory Extract on Liver Structure in Adult Male Rats. Pharm Chem J 57, 395–400 (2023). https://doi.org/10.1007/s11094-023-02896-z

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  • DOI: https://doi.org/10.1007/s11094-023-02896-z

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