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Synthesis and Antiaggregant and Anticoagulant Activity of Amino-Acid Salts and Computer Simulation of the Interaction of Their Structures with the Surface of Cyclooxygenase

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Pharmaceutical Chemistry Journal Aims and scope

Effective drugs with antiaggregant and anticoagulant activity are known to possess side effects. It was hypothesized that compounds synthesized from natural amino acids would possess these pharmacological activities without many of the side effects. In this regard, a number of amino-acid salts of alkali and alkaline-earth metals were synthesized and studied. The newly synthesized compounds were identified using PMR spectra, IR spectroscopy, and elemental analysis. Laboratory studies carried out with isolated blood of healthy volunteers identified seven compounds exhibiting antiaggregant properties. The antiaggregant effects of these compounds on the maximum amplitude of aggregation was comparable to that of acetylsalicylic acid and exceeded it in terms of inhibition of the platelet release reaction. Computer simulation of the interaction of the most active amino-acid salts with the surface of cyclooxygenase confirmed their possible participation in the inhibition of this enzyme.

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Authors and Affiliations

  1. A. I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of the Russian Federation, 20/1 Delegatskaya St, Moscow, 127473, Russia

    K. G. Gurevich

  2. Izhevsk State Medical Academy, MinistryofHealthoftheRussianFederation, 281 Kommunarov St, Izhevsk, 426034, Russia

    A. L. Urakov

  3. Samara National Research University, InstituteofNaturalSciences, 34 Moskovskoe Shosse, Samara, 443086, Russia

    P. P. Purygin & Yu. P. Zarubin

  4. Bashkir State Medical University, Ministry of Health of the Russian Federation, 5 Lenina St, Ufa, 450008, Russia

    T. A. Abzalilov, V. A. Afanasiev, V. E. Sakaev, A. V. Samoredov & V. N. Pavlov

  5. N. F. Gamalei National Research Center of Epidemiology and Microbiology named after Honorary Acad. N. F. Gamaleya, Ministry of Health of the Russian Federation, 18 Gamalei St, Moscow, 123098, Russia

    T. M. Garaev

  6. Privolzhsky Research Medical University, Ministry of Health of the Russian Federation, 10/1 Minina i Pozharskogo Sq, Nizhny Novgorod, 603005, Russia

    L. V. Lovtsova

Authors
  1. K. G. Gurevich
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  2. A. L. Urakov
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  3. P. P. Purygin
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  4. T. A. Abzalilov
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  5. T. M. Garaev
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  6. Yu. P. Zarubin
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  7. V. A. Afanasiev
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  8. V. E. Sakaev
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  9. A. V. Samoredov
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  10. V. N. Pavlov
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  11. L. V. Lovtsova
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Corresponding author

Correspondence to A. L. Urakov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 11, pp. 21 – 27, November, 2022.

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Gurevich, K.G., Urakov, A.L., Purygin, P.P. et al. Synthesis and Antiaggregant and Anticoagulant Activity of Amino-Acid Salts and Computer Simulation of the Interaction of Their Structures with the Surface of Cyclooxygenase. Pharm Chem J 56, 1451–1456 (2023). https://doi.org/10.1007/s11094-023-02812-5

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  • DOI: https://doi.org/10.1007/s11094-023-02812-5

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