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Chemical Constituents and Antidepressant-Like Activity of the Ethanol Extract of Lindera fragrans Leaves

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Pharmaceutical Chemistry Journal Aims and scope

The leaves and bark of Lindera fragrans herbs have been conventionally used in Traditional Chinese Medicine (TCM) as qi regulating drugs. This work was aimed to study the chemical constituents, possible antidepressant activity and mechanism of ethanol extract from L. fragrans leaves. In this study, ultra-high performance liquid chromatography (UPLC) coupled with hybrid quadrupole-orbitrap high-resolution mass spectrometry (UPLC-Q-Orbirap HRMS) technology was used to analyze and identify chemical components of the ethanol extract of L. fragrans leaves. In addition, chronic unpredictable mild stress (CUMS) model was established to measure the behavioral indexes of L. fragrans leaves extract on depressed mice, including weight, sucrose preference, tail suspension time, and serum corticosterone (CORT), serotonin (5-HT) and norepinephrine (NE) detected by ELISA. The results indicate that L. fragrans leaves extract contains approximately 22 compounds and can significantly increase the sucrose preference, reduce the tail suspension time, and regulate the levels of CORT, 5-HT and NE in CUMS depressed mice. This research proved for the first time that L. fragrans leaves extract treatment successfully reduced chronic mild stress-induced depressive-like behaviors in mice, as well as CUMS mice hyperactivity on the hypothalamus-pituitary-adrenal (HPA) axis.

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CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest

Funding

This work was co-supported by the research project of the National Natural Science Foundation of China (NSFC) (No. 31200256), the Open Project Program of Irradiation Preservation Technology Key Laboratory of Sichuan Province, Sichuan Institute of Atomic Energy (No. FZBC2020002), the Funds of Sichuan Science and Technology Program (2021YFSY0041, 2021YFH0064, 2021ZHFP0032, 2020YJ0222, and 2020YFH0061), the Fund of Science and Technology Agency of Chengdu (2019-YF09 – 00049-SN), the research project of the Administration of Traditional Chinese Medicine of Sichuan (2021MS110), and the Fundamental Research Funds for the Central Universities (2682020ZT85), and the 15th Personalized Experimental Project (GX2021160001).

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Authors and Affiliations

  1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China

    Si-Wei Wang, Shu-Yu Xu, Tian Gan, Jia-Hong Li & He-Zhong Jiang

  2. Irradiation Preservation Key Laboratory of Sichuan Province, Radiation Chemistry Department, Sichuan Institute of Atomic Energy, Chengdu, 610100, P. R. China

    Xiao-Bin Zhang

  3. Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China

    Jia-Hong Li & He-Zhong Jiang

  4. College of Medicine, Southwest Jiaotong University, Chengdu, 610031, P. R. China

    Xing Wang

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  1. Si-Wei Wang
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Contributions

Si-Wei Wang: conceptualization, experiment, writing-original draft; Shu-Yu Xu: writing-review and editing; Tian Gan: experiment; Xiao-Bin Zhang and Jia-Hong Li: data curation, visualization; Xing Wang and He-Zhong Jiang: project administration, writing-review and editing, vision and editing of the draft.

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Correspondence to Xing Wang or He-Zhong Jiang.

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Wang, SW., Xu, SY., Gan, T. et al. Chemical Constituents and Antidepressant-Like Activity of the Ethanol Extract of Lindera fragrans Leaves. Pharm Chem J 56, 1358–1368 (2023). https://doi.org/10.1007/s11094-023-02798-0

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  • DOI: https://doi.org/10.1007/s11094-023-02798-0

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