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A Potential Method for Standardization of Multiphytoadaptogen: Tandem Mass Spectrometry for Analysis of Biologically Active Substances from Rhodiola rosea

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Pharmaceutical Chemistry Journal Aims and scope

Tandem mass spectrometry (HPLC-MS/MS) was used to analyze biologically active compounds in extracts of the tuber and roots of Rhodiola rosea (family Crassulaceae) and in the pharmaceutical formulation Multiphytoadaptogen (MPA). Chromatography was run on Acquity UPLC BEH C18 columns with gradient elution. A TSQ Vantage ternary quadrupole mass spectrometer with electrospray ionization was used. MPA, like the Rhodiola rosea tuber/root extract, was found to contain salidroside, rosavin, rosarin, rosiridin, and rhodionin. These results can be used for standardization, identification, and quality control of phytocomplexes containing these Rhodiola rosea compounds to identify grounds for the mechanisms of the biological actions of MPA and studying its novel properties, taking account of the components identified. The PASS computer program was used for in silico evaluation of the spectra of the antitumor activities of these compounds. Antitumor effects were predicted with high probability for all five phytocomponents; the specific characteristic of the actions of individual compounds suggested that combinations might be used for treating a wide spectrum of malignant neoplasms.

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Acknowledgements

This study was partially funded by grants from the Commission for Biomedical Innovations and Technologies, Russian Federation Ministry of Science, and the Basic Long-Term Scientific Research Program of the Russian Federation (2021 – 2030).

Conflict of interests. The authors declare that they have no conflicts of interests.

Author information

Authors and Affiliations

  1. N. N. Blokhina National Oncology Medical Research Center, Ministry of Health of the Russian Federation, 24 Kashirskoe Chausée, 115478, Moscow, Russia

    O. A. Bocharova, I. V. Kazeev, V. E. Shevchenko, E. V. Bocharov, R. V. Karpova, V. S. Kosorukov, V. B. Matveev & I. S. Stilidi

  2. All-Russian Science Research Institute of Medicinal and Aromatic Plants (VILAR), building 1, 7 Grin Street, 117216, Moscow, Russia

    O. P. Sheichenko

  3. V. N. Orekhovich Science Research Institute of Biomedical Chemistry, Building, 8, 10 Pogodinskaya Street, 119121, Moscow, Russia

    V. V. Poroikov & N. S. Ionov

  4. Science Research Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315, Moscow, Russia

    V. G. Kucheryanu

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  1. O. A. Bocharova
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  2. I. V. Kazeev
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  9. V. G. Kucheryanu
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  10. V. S. Kosorukov
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Correspondence to O. A. Bocharova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 1, pp. 32 – 38, January, 2022.

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Bocharova, O.A., Kazeev, I.V., Shevchenko, V.E. et al. A Potential Method for Standardization of Multiphytoadaptogen: Tandem Mass Spectrometry for Analysis of Biologically Active Substances from Rhodiola rosea. Pharm Chem J 56, 78–84 (2022). https://doi.org/10.1007/s11094-022-02607-0

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  • DOI: https://doi.org/10.1007/s11094-022-02607-0

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