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Liposomal Composition Based on Hydroxyaluminum Phthalocyanine and Gold Nanoparticles for Combined Photodynamic and Photothermal Therapy

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Pharmaceutical Chemistry Journal Aims and scope

The present work was aimed at the synthesis, characterization, and cytotoxicity studies of a composition based on liposomes with hydroxyaluminum phthalocyanine (HAPC) and gold nanoparticles (GNP) for combined photodynamic and photothermal therapy. Liposomes were synthesized using HAPC and GNP stabilized with sodium citrate and were obtained from phosphatidylcholine (PC) and cholesterol (CS) by hydration of thin lipid films. Liposomes with diameters of 184 ± 47 nm contained a suspension of HAPC (0.9 mg/mL) and GNP (0.068 mg/mL). Their cytotoxicity on Vero cells and their effect on the activity of a membrane-attacking complex of the complement system were studied. The liposomes exhibited a dose-dependent cytotoxicity that was slightly higher than that of the components and activated the complement system at a concentration corresponding to the IC50 value. However, this effect was not manifested at the expected therapeutic concentration, which indicated the possibility of using them in vivo.

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Authors and Affiliations

  1. A. I. Yevdokimov Moscow State University of Medicine and Dentistry, 20/1 Delegatskaya St., Moscow, 127473, Russia

    L. A. Tararina, O. V. Minaeva, I. V. Maev, A. V. Zaborovsky, D. V. Yunina, K. G. Gurevich & D. N. Andreev

  2. N. P. Ogarev National Research Mordovia State University, 68/1 Bol’shevistskaya St., Saransk, 430005, Russia

    M. N. Zharkov, O. V. Minaeva, E. P. Brodovskaya, E. N. Kovalenko & N. A. Pyataev

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  1. L. A. Tararina
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  2. M. N. Zharkov
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  3. O. V. Minaeva
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  4. E. P. Brodovskaya
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  5. E. N. Kovalenko
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  6. I. V. Maev
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  7. A. V. Zaborovsky
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  8. D. V. Yunina
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  9. K. G. Gurevich
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  10. D. N. Andreev
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  11. N. A. Pyataev
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Corresponding author

Correspondence to A. V. Zaborovsky.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 10, pp. 42 – 47, October, 2021.

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Tararina, L.A., Zharkov, M.N., Minaeva, O.V. et al. Liposomal Composition Based on Hydroxyaluminum Phthalocyanine and Gold Nanoparticles for Combined Photodynamic and Photothermal Therapy. Pharm Chem J 55, 1103–1107 (2022). https://doi.org/10.1007/s11094-021-02543-5

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  • DOI: https://doi.org/10.1007/s11094-021-02543-5

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