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Inhibitors of Sortases of Gram-Positive Bacteria and their Role in the Treatment of Infectious Diseases (Review)

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

The functions of sortase bacterial enzymes and their surface-protein substrates are reviewed. Their role in the pathogenesis of infectious diseases such as pneumonia, septic endocarditis, septic arthritis, mastitis, and cutaneous and gastrointestinal infections are discussed. The importance of sortases for the pathogenesis of the aforementioned diseases has been studied in animal models. Well-known and potential natural and synthetic sortase inhibitors are considered possible compounds for the treatment of these infectious diseases.

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Acknowledgments

The work was supported by a grant from the Russian Science Foundation (Project No. 20-15-00258).

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Authors and Affiliations

  1. N. I. Pirogov Russian National Research Medical University, 9A B. Pirogovskaya St., Moscow, 117997, Russia

    K. V. Kudryavtsev, T. A. Fedotcheva & N. L. Shimanovsky

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  1. K. V. Kudryavtsev
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  2. T. A. Fedotcheva
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  3. N. L. Shimanovsky
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Correspondence to K. V. Kudryavtsev.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 8, pp. 3 – 9, August, 2021.

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Kudryavtsev, K.V., Fedotcheva, T.A. & Shimanovsky, N.L. Inhibitors of Sortases of Gram-Positive Bacteria and their Role in the Treatment of Infectious Diseases (Review). Pharm Chem J 55, 751–756 (2021). https://doi.org/10.1007/s11094-021-02488-9

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  • DOI: https://doi.org/10.1007/s11094-021-02488-9

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