The flavonoid profile of the lyophilized aqueous extract of Caragana jubata shoots was established based on previous studies. The antimicrobial activity of the lyophilizate was studied in vitro using a screening method for determining the antimicrobial activity of herbal preparations because the flavonoids were potential microorganism inhibitors according to the literature. The bacteriostatic and fungistatic activity was studied in vitro using double serial dilutions of the preparations in liquid growth media. The results revealed moderate antimicrobial activity of the lyophilized aqueous extract of C. jubata against all tested strains of pathogenic Gram-positive and Gram-negative bacteria (S. aureus, E. coli, P. vulgaris, P. aeruginosa) and yeast-like and mycelial fungi (C. albicans, M. canis). The results allowed the lyophilized aqueous extract to be recommended for treating skin and mucous membrane diseases associated with bacterial inflammatory processes.
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References
S. Chinbatyn, Author’s Abstract of a Doctoral Dissertation in Biological Sciences, St. Petersburg (1997).
I. A. Artem’eva, V. D. Molokov, and T. P. Zyubr, Int. J. Immunorehabil., 11(1), 111 – 112 (2009).
SP RF, XIIIth Ed., Min. Health RF, Moscow (2015).
European Pharmacopoeia, 7th Ed., Vols. 1 and 2 with Supplements (2011).
Pharmacopoeia of the People’s Republic of China, Vol. 1 (English Ed.), Chemical Industry Press, Chinese Pharmacopoeia Commission (2010).
The Japanese Pharmacopoeia, 16th Ed., The Committee on Japanese Pharmacopoeia, Tokyo (2011).
United States Pharmacopeia, 30 National Formulary 25, The Official Compendia of Standards (2007).
British Pharmacopoeia, 5 vols., Stationery Office, London (2008).
P. A. Kakorin, S. V. Kozin, G. V. Ramenskaya, and L. A. Pavlova, Eksp. Klin. Farmakol., 81(3), 28 – 33 (2018).
P. A. Kakorin, I. B. Perova, E. D. Rybakova, et al., Khim.-farm. Zh., 51(11), 29 – 34 (2017).
J. Liu and P. G. Xiao, Phytother. Res., 8(8), 445 – 451 (1994).
S. A. Vichkanova, Doctoral Dissertation in Biological Sciences, Moscow (1982).
S. A. Vichkanova, Medicines from Plants (VILAR Experience): Scientific Edition Adris, Moscow (2009).
I. V. Shilova, N. I. Suslov, I. A. Samylina, et al., Khim.-farm. Zh., 53(11), 37 – 41 (2019).
A. N. Mironov (ed.), Handbook for Preclinical Drug Trials [in Russian], Vol. 1, Grif i K, Moscow (2012).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 4, pp. 42 – 44, April, 2020.
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Kakorin, P.A., Fateeva, T.V., Tereshkina, O.I. et al. Antimicrobial Activity of Lyophilized Aqueous Extract from Caragana Jubata (Pall.) Poir.. Pharm Chem J 54, 290–292 (2020). https://doi.org/10.1007/s11094-020-02193-z
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DOI: https://doi.org/10.1007/s11094-020-02193-z