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Synthesis of New Bis(Indolyl)Methanes Catalyzed by Benzylsulfamic Acid and Evaluation of Their Antimicrobial Activities

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Pharmaceutical Chemistry Journal Aims and scope

Benzylsulfamic acid has been prepared and introduced as a new heterogeneous acid catalyst. This reagent was used for the synthesis of new bis(indolyl)methanes 3a – 3f via reaction of bis-aldehydes 1 with indoles 2 at 100°C. All reactions were performed under solvent-free conditions with high to excellent yields. The synthesized bis(indolyl)methanes were evaluated for their antibacterial and antifungal activities.

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Scheme 2.
Fig. 1.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran

    Sara Soltani, Naser Montazeri & Masoud Mohammadi Zeydi

  2. Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran

    Majid M. Heravi

Authors
  1. Sara Soltani
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  2. Naser Montazeri
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  3. Masoud Mohammadi Zeydi
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  4. Majid M. Heravi
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Correspondence to Naser Montazeri.

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Soltani, S., Montazeri, N., Zeydi, M.M. et al. Synthesis of New Bis(Indolyl)Methanes Catalyzed by Benzylsulfamic Acid and Evaluation of Their Antimicrobial Activities. Pharm Chem J 53, 947–952 (2020). https://doi.org/10.1007/s11094-020-02103-3

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  • DOI: https://doi.org/10.1007/s11094-020-02103-3

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