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Main Aspects of Pharmaceutical Gel Development for Peroral Administration

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

The main development issues for pharmaceutical gels for peroral administration, a modern dosage form, are reviewed. Patent and literature searches for gel forms for peroral administration were performed. The main development issues for gels for peroral administration are the need for an experimental and science-based approach to correcting the taste, providing the optimal rheological characteristics that determine the stability to aggregation and release of active ingredients from the dosage form, and selecting the packaging and dispensing device for improved therapeutic efficacy. Principles for designing peroral formulations as gels with prolonged release are discussed.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the RF, Moscow, 119991, Russia

    E. O. Bakhrushina, M. N. Anurova, N. B. Demina & G. Yu. Ivannikov

Authors
  1. E. O. Bakhrushina
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  2. M. N. Anurova
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  3. N. B. Demina
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  4. G. Yu. Ivannikov
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Corresponding author

Correspondence to N. B. Demina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 9, pp. 23 – 32, September, 2019.

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Bakhrushina, E.O., Anurova, M.N., Demina, N.B. et al. Main Aspects of Pharmaceutical Gel Development for Peroral Administration. Pharm Chem J 53, 838–844 (2019). https://doi.org/10.1007/s11094-019-02087-9

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  • DOI: https://doi.org/10.1007/s11094-019-02087-9

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