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Comparison of Quantitative Analytical Techniques for Dabigatran in Blood Plasma of Humans with Knee Replacements

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Pharmaceutical Chemistry Journal Aims and scope

Two different literature methods were used to compare the experimental efficacy and accuracy of dabigatran assays in blood of 30 patients with knee replacements. Blood plasma was collected from patients who underwent anticoagulant therapy and were administered the medicine at a dose of 220 mg. Residual and peak dabigatran concentrations were determined by HPLC-MS and HPLC-MS/MS.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russia

    A. V. Kozlov & V. V. Smirnov

  2. Russian Medical Academy of Continuous Professional Education, Ministry of Health of the RF, Moscow, 125993, Russia

    D. A. Sychev

  3. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315, Russia

    P. O. Bochkov

  4. Research and Education Center, Peoples’ Friendship University of Russia, Moscow, 117198, Russia

    V. V. Chistyakov, E. S. Stepanova & L. M. Makarenkova

Authors
  1. A. V. Kozlov
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  2. V. V. Smirnov
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  3. D. A. Sychev
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  4. P. O. Bochkov
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  5. V. V. Chistyakov
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  6. E. S. Stepanova
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  7. L. M. Makarenkova
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Corresponding author

Correspondence to A. V. Kozlov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 8, pp. 59 – 63, August, 2019.

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Kozlov, A.V., Smirnov, V.V., Sychev, D.A. et al. Comparison of Quantitative Analytical Techniques for Dabigatran in Blood Plasma of Humans with Knee Replacements. Pharm Chem J 53, 771–774 (2019). https://doi.org/10.1007/s11094-019-02077-x

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  • DOI: https://doi.org/10.1007/s11094-019-02077-x

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