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Synthesis and Pharmacological Activity of 2-(Diethylamino)Ethyl 9-Hydroxy-9H-Fluorene-9-Carboxylate Hydrochloride

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Pharmaceutical Chemistry Journal Aims and scope

New fluorenecarboxylic acid derivatives (structural analogs of amizil) were synthesized. A compound with low toxicity (LD50 = 45 ± 9.9 mg/kg) and antidepressant and antianxiety effects was identified. The central and peripheral muscarinic anticholinergic properties of 2-dimethylaminoethyl 9-hydroxyfluorene-9-carboxylate were studied using an arecoline tremor model. Apharmacological analysis showed that the new amizil structural analog exhibited pronounced central muscarinic anticholinergic activity and did not possess peripheral muscarinic anticholinergic effects. The advantages of the tested compound over amizil, amitriptyline that is widely used in the clinic, and the benzodiazepine tranquilizer diazepam were discussed. The results indicated that 2-diethylaminoethyl 9-hydroxyfluorene-9-carboxylate was promising for further development for the treatment of depressive and anxiety disorders.

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Authors and Affiliations

  1. Institute of Experimental Medicine, St. Petersburg, 197375, Russia

    L. K. Khnychenko & E. E. Yakovleva

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  1. L. K. Khnychenko
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  2. E. E. Yakovleva
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Correspondence to L. K. Khnychenko.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 3, pp. 26 – 29, March, 2019.

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Khnychenko, L.K., Yakovleva, E.E. Synthesis and Pharmacological Activity of 2-(Diethylamino)Ethyl 9-Hydroxy-9H-Fluorene-9-Carboxylate Hydrochloride. Pharm Chem J 53, 216–219 (2019). https://doi.org/10.1007/s11094-019-01982-5

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  • DOI: https://doi.org/10.1007/s11094-019-01982-5

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