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Physicochemical Properties of the Original Antidepressant GSB-106 and Development of a Method for the Analysis of GSB-106 Substance

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Pharmaceutical Chemistry Journal Aims and scope

Studies at the V. V. Zakusov Science Research Institute of Pharmacology have worked on the basis of the β-pleated structure of loop 4 of brain-derived neurotrophic factor (BDNF) to construct its dimeric peptide mimetic - GSB-106, bis-(N-monosuccinyl-L-serine-L-lysine) hexamethylenediamide. GSB-106 is being developed as an antidepressant with a BDNF-ergic mechanism of action. We report here studies of the physicochemical properties of GSB-106 and development of a method for analysis of GSB-106 substance. The main pharmacopeia quality indicators were determined and IR and NMR spectra were obtained from samples of substance. A method was developed for detecting contaminants in substance using TLC and HPLC.

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Authors and Affiliations

  1. V. V. Zakusov Science Research Institute of Pharmacology, 6 Baltiiskaya Street, 125315, Moscow, Russia

    A. V. Tarasyuk, N. M. Sazonova, A. N. Shumskii, A. L. Nekrashevich, P. I. Antipov, L. M. Gaevaya, L. N. Grushevskaya & S. V. Minaev

Authors
  1. A. V. Tarasyuk
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  2. N. M. Sazonova
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  3. A. N. Shumskii
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  4. A. L. Nekrashevich
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  5. P. I. Antipov
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  6. L. M. Gaevaya
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  7. L. N. Grushevskaya
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  8. S. V. Minaev
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Corresponding author

Correspondence to A. V. Tarasyuk.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 1, pp. 58 – 64, January, 2019.

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Tarasyuk, A.V., Sazonova, N.M., Shumskii, A.N. et al. Physicochemical Properties of the Original Antidepressant GSB-106 and Development of a Method for the Analysis of GSB-106 Substance. Pharm Chem J 53, 71–78 (2019). https://doi.org/10.1007/s11094-019-01958-5

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  • DOI: https://doi.org/10.1007/s11094-019-01958-5

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