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Chemical Enhancers or Transcutaneous Conductors: Transcutol

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

The concept of enhancers or transcutaneous conductors and their classification and mechanism of action are discussed. Special attention is paid to transcutol, a conductor with pronounced solubilizing and penetrating properties that facilitates the accumulation of locally applied medicines in the skin lipid layer without perturbing its structure. The transcutaneous action effectiveness of chemical enhancers is shown to depend on not only the structure and concentration but also the physicochemical characteristics of the penetrating drugs. Diffusional transport in the stratum corneum and the ability to monitor the occurring processes can be used to optimize the design of drugs for transcutaneous targeted delivery.

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Authors and Affiliations

  1. Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, 400131, Russia

    O. G. Strusovskaya, S. V. Poroiskii & A. G. Strusovskaya

  2. Volgograd Medical Scientific Center, Volgograd, 400131, Russia

    O. G. Strusovskaya & S. V. Poroiskii

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  1. O. G. Strusovskaya
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  2. S. V. Poroiskii
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  3. A. G. Strusovskaya
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Correspondence to O. G. Strusovskaya.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 11, pp. 3 – 8, November, 2018.

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Strusovskaya, O.G., Poroiskii, S.V. & Strusovskaya, A.G. Chemical Enhancers or Transcutaneous Conductors: Transcutol. Pharm Chem J 52, 879–884 (2019). https://doi.org/10.1007/s11094-019-01920-5

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  • DOI: https://doi.org/10.1007/s11094-019-01920-5

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