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Effects of Novel Potential Analgesic Compounds on the Cardiovascular and Respiratory Systems

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Pharmaceutical Chemistry Journal Aims and scope

The polypeptide analgesic compounds APCH3 (a TRPV1 receptor inhibitor) and PT1 (a P2X3 receptor inhibitor) were shown not to act on the cardiovascular system or respiratory system when given either as single or multiple doses in mice. The low molecular weight compound sevanol (an ASIC3 receptor inhibitor) had no effect on the cardiovascular system, but prolonged use for 14 days affected measures of the respiratory system, significantly increasing respiratory rate and peak expiratory flow rate.

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Authors and Affiliations

  1. Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 6, Prospekt Nauki, Pushchino, 142290, Moscow Region, Russia

    Yu. A. Palikova, L. A. Skobtsova, V. A. Palikov, O. N. Khokhlova, A. V. Lobanov, G. A. Slashcheva, D. I. Rzhevskii, V. B. Rudenko, E. A. Kalabina, G. A. Osipova & I. A. D’yachenko

  2. Pushchino Scientific Center, Russian Academy of Sciences, 3, Prospekt Nauki, Pushchino, 142290, Moscow Region, Russia

    O. N. Khokhlova, A. V. Lobanov, D. I. Rzhevskii & I. A. D’yachenko

  3. Pushchino State Natural Sciences Institute, 3, Prospekt Nauki, Pushchino, 142290, Moscow Region, Russia

    Yu. A. Palikova, L. A. Skobtsova, V. A. Palikov, G. I. Belous, A. N. Yavorskii & I. A. D’yachenko

  4. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10, Miklukho-Maklaya Street, 117997, Moscow, Russia

    Ya. A. Andreev, Yu. A. Logashina, S. A. Kozlov & G. Elyakova

  5. First I. M. Sechenov Moscow State Medical University, Russian Ministry of Health, Institute of Molecular Medicine, 8 Trubetskaya Street, 119991, Moscow, Russia

    Ya. A. Andreev & Yu. A. Logashina

Authors
  1. Yu. A. Palikova
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  2. L. A. Skobtsova
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  3. V. A. Palikov
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  4. G. I. Belous
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  5. O. N. Khokhlova
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  6. A. V. Lobanov
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  7. G. A. Slashcheva
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  8. D. I. Rzhevskii
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  9. V. B. Rudenko
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  10. E. A. Kalabina
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  11. G. A. Osipova
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  12. Ya. A. Andreev
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  13. Yu. A. Logashina
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  14. S. A. Kozlov
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  15. A. N. Yavorskii
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  16. G. Elyakova
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  17. I. A. D’yachenko
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 7, pp. 9 – 11, July, 2018.

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Palikova, Y.A., Skobtsova, L.A., Palikov, V.A. et al. Effects of Novel Potential Analgesic Compounds on the Cardiovascular and Respiratory Systems. Pharm Chem J 52, 593–595 (2018). https://doi.org/10.1007/s11094-018-1865-7

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  • DOI: https://doi.org/10.1007/s11094-018-1865-7

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