A deficiency of brain-derived neurotrophic factor (BDNF) has now been demonstrated in many studies to play a central role in the pathogenesis of depression. The dimeric dipeptide BDNF-mimetic bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide or GSB-106 was discovered at Zakusov State Institute of Pharmacology. Previously, the antidepressant properties of GSB-106 at doses of 0.1 – 1 mg/kg i.p. were established in mice in the Porsolt forced swim test. An oral dosage form of GSB-106 was developed. The present research focused on the antidepressant activity of the GSB-106 dosage form in mice in the Porsolt forced swim test. It is established that GSB-106 in the oral dosage form possesses antidepressant activity for 14 d at doses of 0.05, 0.1, and 1 mg/kg.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Y. Dwivedi, Am. J. Geriatr. Psychiatry, 21(5), 433 – 449 (2013).
C. Jiang and S. R. Salton, Transl. Neurosci., 4(1), 46 – 58 (2013).
M. Polyakova, K. Stuke, K. Schuemberg, et al., J. Affective Disord., 174, 432 – 440 (2015).
L. Deutschenbaur, J. Beck, A. Kiyhankhadiv, et al., Prog. Neuropsychopharmacol. Biol. Psychiatry, 64, 325 – 333 (2016).
S. B. Seredenin and T. A. Gudasheva, RU Pat. No. 2,410,392, Jan. 27, 2011.
T. A. Gudasheva, A. V. Tarasyuk, S. V. Pomogaibo, et al., Bioorg. Khim., 38(3), 280 – 290 (2012).
S. B. Seredenin, T. A. Voronina, T. A. Gudasheva, et al., Acta Nat., 5(4), 116 – 120 (2013).
T. A. Gudasheva, I. O. Logvinov, T. A. Antipova, and S. B. Seredenin, Dokl. Akad. Nauk, 451(5), 577 – 580 (2013).
T. A. Gudasheva, I. O. Logvinov, P. Yu. Povarnina, et al., Dokl. Akad. Nauk, 460(3), 346 – 348 (2015).
J. J. Buccafusco, Methods of Behavior Analysis in Neuroscience, 2nd Ed., CRC Press, Florida (2009).
V. Castagné, R. D. Porsolt, and P. Moser, Eur. J. Pharmacol., 616(1 – 3), 128 – 133 (2009).
Acknowledgments
The work was sponsored by a grant of the RAS Presidium “Study of the role of synaptogenesis and neurogenesis in the antidepressant mechanism of action of brain-derived neurotrophic factor using its dipeptide mimetics, the first in a class of potential antidepressants.”
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 5, pp. 15 – 17, May, 2018.
Rights and permissions
About this article
Cite this article
Tallerova, A.V., Povarnina, P.Y., Blynskaya, E.V. et al. Antidepressant Effect of a Dipeptide Brain-Derived-Neurotrophic-Factor Mimetic (GSB-106) in a Generic Oral Dosage Form. Pharm Chem J 52, 397–399 (2018). https://doi.org/10.1007/s11094-018-1828-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-018-1828-z