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Microencapsulation of Imatinib Methanesulfonate

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Pharmaceutical Chemistry Journal Aims and scope

(Protamine—pectin)4 and (protamine—pectin)8 microcapsules and those containing also Ag nanoparticles were formed using the polyelectrolyte layer-by-layer (LbL) self-assembly method. The efficiency of imatinib methanesulfonate encapsulation in the microcapsules was 85.0 ± 6.0%. Microcapsules containing up to 50 mass% imatinib methanesulfonate and providing a prolonged release profile of the encapsulated drug were prepared. Encapsulation of imatinib in microcapsules increased its cytostatic activity (IC50 values reduced by 1.2 – 3.5 times) as compared with the free drug on the Molt-4, K-562, and KG-1 cell lines.

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Acknowledgments

The work was sponsored by the Belarusian Republic Foundation for Basic Research under contract No. X14-137.

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Authors and Affiliations

  1. Institute of the Chemistry of New Materials, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    K. S. Gilevskaya, Zh. V. Ignatovich, E. V. Koroleva & V. E. Agabekov

  2. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    M. B. Golubeva

Authors
  1. K. S. Gilevskaya
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  2. Zh. V. Ignatovich
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  3. M. B. Golubeva
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  4. E. V. Koroleva
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  5. V. E. Agabekov
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Corresponding author

Correspondence to K. S. Gilevskaya.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 6, pp. 48 – 53, June, 2017.

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Gilevskaya, K.S., Ignatovich, Z.V., Golubeva, M.B. et al. Microencapsulation of Imatinib Methanesulfonate. Pharm Chem J 51, 486–490 (2017). https://doi.org/10.1007/s11094-017-1639-7

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  • DOI: https://doi.org/10.1007/s11094-017-1639-7

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