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Synthesis, Immunomodulating and Antitumor Activities of Copolymers of Dialkylaminoethyl Methacrylates and Vinylsaccharides

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Water-soluble random copolymers of N,N-(dimethylamino)ethyl methacrylate or N,N-(diethylamino)ethyl methacrylate with vinylsaccharides (N-methacryloyl aminoglucose, 3-O-methacryloyl glucose, 1-O-methacryloyl sorbose) were synthesized. The copolymers differed in composition, structure of the carbohydrate fragment, and type of carbohydrate–main-polymer-chain bonds. The immunomodulating activity and antitumor properties of the synthesized copolymers were established. Copolymers containing sorbose residues possessed the most pronounced immunodepressant properties.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, 31 Bol’shoi Prosp., St. Petersburg, 199004, Russia

    O. V. Nazarova, Yu. I. Zolotova, O. N. Zhuravskaya, T. N. Nekrasova & E. F. Panarin

  2. N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758, Russia

    L. S. Potapenkova & A. N. Stukov

  3. Peter the Great St. Petersburg Polytechnic University, 29 Politekhnicheskaya St., St. Petersburg, 195251, Russia

    E. F. Panarin

Authors
  1. O. V. Nazarova
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  2. L. S. Potapenkova
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  3. A. N. Stukov
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  4. Yu. I. Zolotova
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  5. O. N. Zhuravskaya
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  6. T. N. Nekrasova
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  7. E. F. Panarin
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Corresponding author

Correspondence to A. N. Stukov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 4, pp. 3 – 7, April, 2017.

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Nazarova, O.V., Potapenkova, L.S., Stukov, A.N. et al. Synthesis, Immunomodulating and Antitumor Activities of Copolymers of Dialkylaminoethyl Methacrylates and Vinylsaccharides. Pharm Chem J 51, 245–249 (2017). https://doi.org/10.1007/s11094-017-1591-6

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  • DOI: https://doi.org/10.1007/s11094-017-1591-6

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