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Selection of Standardization Parameters and Development of Quality Control Methods for Isoleucyl-Tryptophan Dipeptide Coordination Complex with Iron(II) (Timofer)

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Pharmaceutical Chemistry Journal Aims and scope

The coordination complex of the dipeptide isoleucyl-tryptophan with Fe(II) possesses immunostimulating activity and is effective for treating iron- and immunodeficiency and pulmonary, rheumatological, and urological diseases. Results are presented from the development of quantitative assays for isoleucyl-tryptophan– Fe(II) using the Fe(II) ion and the tryptophan indole moiety. The standardization parameters of a reference sample, drug substance, and its dosage form are determined.

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    N. D. Bunyatyan

  2. State Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation, Moscow, 127051, Russia

    N. D. Bunyatyan, B. M. Kholnazarov, Yu. V. Olefir & G. M. Bobizoda

Authors
  1. N. D. Bunyatyan
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  2. B. M. Kholnazarov
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  3. Yu. V. Olefir
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  4. G. M. Bobizoda
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 9, pp. 51 – 55, September, 2016.

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Bunyatyan, N.D., Kholnazarov, B.M., Olefir, Y.V. et al. Selection of Standardization Parameters and Development of Quality Control Methods for Isoleucyl-Tryptophan Dipeptide Coordination Complex with Iron(II) (Timofer). Pharm Chem J 50, 620–624 (2016). https://doi.org/10.1007/s11094-016-1502-2

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  • DOI: https://doi.org/10.1007/s11094-016-1502-2

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