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Synthesis and Molecular-Weight Characteristics of N-Oxidized Copolymers of N-Vinylpyrrolidone and 2-Methyl-5-Vinylpyridine

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Aseries of N-oxides of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine copolymers with various degrees of oxidation were prepared via oxidation of the copolymers by peracetic acid. The N-oxidation kinetic rate constants were calculated using UV spectrophotometry. The temperature dependence of the limiting N-oxidation was determined. The molecular-weight characteristics of the N-oxidized copolymers were established using 13C NMR methods. An approach based on direct UV spectrophotometry was proposed for practical monitoring of the reaction completion (degree of conversion).

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University of Fine Chemical Technologies (MITKhT), 86 Vernadskogo Prosp, Moscow, 119571, Russia

    E. V. Vorfolomeeva, S. A. Kedik, A. V. Panov, E. S. Zhavoronok, M. S. Starchenkova & D. V. Vasil’eva

  2. Institute of Pharmaceutical Technologies, 21/32 Skolkovskoe Shosse, 121353, Moscow, Russia

    E. V. Vorfolomeeva, S. A. Kedik, A. V. Panov, E. S. Zhavoronok, Yu. S. Efimov & G. V. Zatonskii

Authors
  1. E. V. Vorfolomeeva
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  2. S. A. Kedik
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  3. A. V. Panov
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  4. E. S. Zhavoronok
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  5. Yu. S. Efimov
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  6. M. S. Starchenkova
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  7. D. V. Vasil’eva
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  8. G. V. Zatonskii
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Correspondence to E. V. Vorfolomeeva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 8, pp. 39 – 43, August, 2015.

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Vorfolomeeva, E.V., Kedik, S.A., Panov, A.V. et al. Synthesis and Molecular-Weight Characteristics of N-Oxidized Copolymers of N-Vinylpyrrolidone and 2-Methyl-5-Vinylpyridine. Pharm Chem J 49, 554–558 (2015). https://doi.org/10.1007/s11094-015-1326-5

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  • DOI: https://doi.org/10.1007/s11094-015-1326-5

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