Skip to main content
SpringerLink
Log in

Synthesis and Antiviral Activity of Adamantylpeptides Against Hepatitis C Virus

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

New adamantane derivatives with short peptides were synthesized and their in vitro antiviral activity against hepatitis C virus (HCV) was studied. Experiments in pig embryo kidney cells (PEKC) showed that 1-(1-adamantyl)ethylamine derivatives with tri- and tetrapeptide residues were able to suppress HCV replication. Furthermore, this class of compounds was shown to have direct actions on the infective properties of hepatitis C virions (virucidal activity).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1

Similar content being viewed by others

References

  1. S. D. Griffin, Proc. Natl. Acad. Sci. USA, 106, 12567 – 12568 (2009).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. S. Martin and R. G. Parton, Nat. Rev. Mol. Cell. Biol., 7(5), 373 – 378 (2006).

    Article  CAS  PubMed  Google Scholar 

  3. G. Haqshenas, J. M. Mackenzie, and E. J. Dong, Gowans J. Gen. Virol., 88, 134 – 142 (2007).

    Article  CAS  PubMed  Google Scholar 

  4. P. Luika, C. Chew, and J. Aittoniemi, Proc. Natl. Acad. Sci. USA, 106(31), 12,712 – 12,716 (2009).

    Article  Google Scholar 

  5. V. A. Shibnev, T. M. Garaev, M. P. Finogenova, et al., Khim.-Farm. Zh., 46(1), 36 – 40 (2012); Pharm. Chem. J., 46(1), 1 – 6 (2012).

  6. Russian Federation Patent RU 2461544 C1.

  7. S. D. Griffin, R. Harvey, D. S. Clarke, et al., J. Gen. Virol., 85, 451 – 461 (2004).

    Article  CAS  PubMed  Google Scholar 

  8. T. L. Foster, M. Verow, and A. L. Wozniak., Hepatology, 54(1), 79 – 90 (2011).

    Article  CAS  PubMed  Google Scholar 

  9. P. G. Deryabin and D. K. L’vov, Dokl. Akad. Nauk Ros. Fed., No. 5, 688 – 691 (1998).

  10. V. A. Shibnev, D. V. Mishin, T. M. Garaev, et al., Byul. Éksperim. Biol. Med., 151(5), 549 – 551 (2011).

    Google Scholar 

  11. V. D. Belyakov, A. A. Degtyarev, and Yu. G. Ivannikov, Quality and Efficacy of Antiepidemic Measures [in Russian], Meditsina, Leningrad (1981), pp. 130 – 131.

  12. S. D. Griffin, L. P. Beales, and D. S. Clarke, FEBS Let., 30, 34 – 38 (2003).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. D. I. Ivanovskii Institute of Virology, N. F. Gamaleya Federal Science Research Center for Epidemiology and Microbiology, Russian Ministry of Health, Moscow, Russia

    V. A. Shibnev, T. M. Garaev, P. G. Deryabin, M. P. Finogenova & D. V. Mishin

Authors
  1. V. A. Shibnev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. M. Garaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. G. Deryabin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. P. Finogenova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. V. Mishin
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 7, pp. 20 – 24, July, 2015.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shibnev, V.A., Garaev, T.M., Deryabin, P.G. et al. Synthesis and Antiviral Activity of Adamantylpeptides Against Hepatitis C Virus. Pharm Chem J 49, 449–454 (2015). https://doi.org/10.1007/s11094-015-1302-0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-015-1302-0

Keywords

Search

Navigation